A case report of a spontaneous gastrointestinal stromal tumor (GIST) occurring in a F344 Rat

Toxicologic Pathology

Volumn 34, Issue 2, 2006, Pages 164-167

  Fujimoto, Hitoshi ^a   Shibutani, Makoto ^a   Kuroiwa, Keiko ^a   Inoue, Kaoru ^a   Woo, Gye Hyeong ^a   U, Mami ^a   Hirose, Masao ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

F344 rat; Gastrointestinal stromal tumor (GIST); Immunohistochemistry; Interstitial cell of Cajal; KIT; Spontaneous occurrence

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALDESMON; CD34 ANTIGEN; CYTOKERATIN; DESMIN; PROTEIN S 100; SYNAPTOPHYSIN; VIMENTIN;

ANIMAL CELL; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BONE MARROW; CACHEXIA; CARCINOGENICITY; CELL DIFFERENTIATION; CYTOPLASM; ESOPHAGUS; ESOPHAGUS MUSCLE; FEMALE; FEMUR; FORESTOMACH; GASTROINTESTINAL STROMAL TUMOR; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER; MALE; METASTASIS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE; SPLEEN; TUMOR CELL; TUMOR VOLUME;

ACTINS; ANIMALS; ANTIGENS, CD34; GASTROINTESTINAL NEOPLASMS; GASTROINTESTINAL STROMAL TUMORS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS C-KIT; RATS; RATS, INBRED F344; RODENT DISEASES; S100 PROTEINS; VIMENTIN;

ANIMALIA;

EID: 33645003252     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1080/01926230600588588     Document Type: Article

References (20)

1. Del Piero, F., Summers, B. A., Cummings, J. F., Mandelli, G., and Blomme, E. A. (2001). Gastrointestinal stromal tumors in equids. Vet Pathol 38, 689-97.
2. Frost, D., Lasota, J., and Miettinen, M. (2003). Gastrointestinal stromal tumors and leiomyomas in the dog: a histopathologic, immunohistochemical, and molecular genetic study of 50 cases. Vet Pathol 40, 42-54.
3. Hafner, S., Harmon, B. G., and King, T. (2001). Gastrointestinal stromal tumors of the equine cecum. Vet Pathol 38, 24-6.
4. Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., Muhammad Tunio, G., Matsuzawa, Y., Kanakura, Y., Shinomura, Y., and Kitamura, Y. (1998). Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279, 577-80.
5. Kindblom, L. G., Remotti, H. E., Aldenborg, F., and Meis-Kindblom, J. M. (1998). Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 152, 1259-69.
6. LaRock, R. G., and Ginn, P. E. (1997). Immunohistochemical staining characteristics of canine gastrointestinal stromal tumors. Vet Pathol 34, 303-11.
7. Mazur, M. T., and Clark, H. B. (1983). Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol 7, 507-19.
8. Miettinen, M., Sobin, L. H., and Lasota, J. (2005). Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol 29, 52-68.
9. Miettinen, M., and Lasota, J. (2001). Gastrointestinal stromal tumors - definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 438, 1-12.
10. Miettinen, M., Blay, J. Y., and Sobin, L. H. (2000). Mesenchymal tumours of the stomach. In Pathology and Genetics of Tumours of the Digestive System. World Health Organization Classification of Tumours (S. R. Hamilton and L. A. Aaltomen, eds.), pp. 62-65. IARC Press, Lyon, France.
11. Miettinen, M. M., Sarlomo-Rikala, M., Kovatich, A. J., and Lasota, J. (1999). Calponin and h-caldesmon in soft tissue tumors: consistent h-caldesmon immunoreactivity in gastrointestinal stromal tumors indicates traits of smooth muscle differentiation. Mod Pathol 12, 756-62.
12. Miettinen, M., Virolainen, M., and Sarlomo-Rikala, M. (1995). Gastrointestinal stromal tumors - value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J Surg Pathol 19, 207-16.
13. Monihan, J. M., Carr, N. J., and Sobin, L. H. (1994). CD34 immunoexpression in stromal tumours of the gastrointestinal tract and in mesenteric fibromatoses. Histopathology 25, 469-73.
14. Mukaisho, K. I., Miwa, K., Totsuka, Y., Shimomura, A., Sugihara, H., Wakabayashi, K., and Hattori, T. (2005). Induction of gastric GIST in rat and establishment of GIST cell line. Cancer Lett (in press). doi:10.1016/j.canlet. 2005.02.046
15. Orosz, Z., Tornóczky, T., and Sápi, Z. (2005). Gastrointestinal stromal tumors:a clinicopathologic and immunohistochemical study of 136 cases. Pathol Oncol Res 11, 11-21.
16. Robinson, T. L., Sircar, K., Hewlett, B. R., Chorneyko, K., Riddell, R. H., and Huizinga, J. D. (2000). Gastrointestinal stromal tumors may originate from a subset of CD34-positive interstitial cells of Cajal. Am J Pathol 156, 1157-63.
17. Rosai, J. (1996). Stromal tumors. In Ackerman's Surgical Pathology, 8th ed, 691-3. Mosby-Year Book, St Louis, Chicago.
18. Rosai, J. (2003). GIST: an update. Int J Surg Pathol 11, 177-186.
19. Sircar, K., Hewlett, B. R., Huizinga, J. D., Chorneyko, K., Berezin, I., and Riddell, R. H. (1999). Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol 23, 377-89.
20. Tazawa, K., Tsukada, K., Makuuchi, H., and Tsutsumi, Y. (1999). An immunohistochemical and clinicopathological study of gastrointestinal stromal tumors. Pathol Int 49, 786-98.