Evaluation of a 1 step TRAb assay for the detection of high-affinity components to hTSHR: Evidences indicating superiority of the assay in the lower TRAb range

Endocrine Journal

Volumn 53, Issue 1, 2006, Pages 147-155

  Ishihara, Takashi ^a   Saiki, Yasuhiko ^a   Ikekubo, Katsuji ^a   Hino, Megumu ^a   Ikeda, Kaori ^a   Son, Cyeol ^a   Iwakura, Toshio ^a   Kobayashi, Hiromasa ^a   Mori, Toru ^b  

^a KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

^b Higashiyama Takeda Hospital   (Japan)

Author keywords

Competitive binding assay; Graves' disease; TBII; TRab; TSHR

Indexed keywords

THYROTROPIN I 125; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY;

ABSORPTION; ARTICLE; ASSAY; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; GRAVES DISEASE; HUMAN; INCUBATION TIME; MAJOR CLINICAL STUDY; QUANTITATIVE ANALYSIS; RECEPTOR AFFINITY;

ANTIBODY AFFINITY; AUTOANTIBODIES; BINDING, COMPETITIVE; BIOLOGICAL ASSAY; GRAVES DISEASE; HUMANS; RADIOIMMUNOASSAY; RADIOLIGAND ASSAY; RECEPTORS, THYROTROPIN; SENSITIVITY AND SPECIFICITY;

EID: 33644993194     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.53.147     Document Type: Article

References (34)

1. Smith BR, McLachlan SM, Furmaniak J (1988) Autoantibodies to the thyrotropin receptor. Endocr Rev 9: 106-121.
2. Mori T, Akamizu T, Kosugi S, Sugawa H, Inoue D, Okuda J, Ueda Y (1994) Recent progress in TSH receptor studies with a new concept of autoimmune TSH receptor disease. Endocr J 41: 1-11.
3. Kohn LD, Shimura H, Shimura Y, Hidaka A, Giuliani C, Napolitano G, Ohmori M, Laglia G, Saji M (1995) The thyrotropin receptor. Vitam Horm 50: 287-384.
4. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM (1998) The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 19: 673-716.
5. Costagliola S, Morgenthaler NG, Hoermann R, Badenhoop K, Struck K, Freitag D, Poertl S, Weglohner W, Hollidt JM, Quadbeck B, Dumont JE, Schumm-Draeger PM, Bergmann A, Mann K, Vassart G, Usadel KH (1999) Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease. J Clin Endocrinol Metab 84: 90-97.
6. Morgenthaler NG (1999) New assay systems for thyrotropin receptor antibodies. Thyroid 6: 251-260.
7. Kamijo K (2003) TSH-receptor antibody measurement in patients with various thyrotoxicosis and Hashimoto's thyroiditis: a comparison of two two-step assays, coated plate ELISA using porcine TSH-receptor and coated tube radioassay using human recombinant TSH-receptor. Endocr J 50: 113-116.
8. Kasagi K, Konishi J, Iida Y, Ikekubo K, Mori T, Kuma K, Torizuka K (1982) A new in vitro assay for thyroid stimulator using cultured thyroid cells: effect of sodium chloride on adenosine 3′,5′-monophosphate increase. J Clin Endocrinol Metab 54: 108-114.
9. Inui T, Kouki T, Yamashiro K, Hachiya T, Ochi Y, Kajita Y, Sato Y, Nagata A (1998) Increase of thyroid stimulating activity in Graves' immunoglobulin-G by high polyethylene glycol concentrations using porcine thyroid cell assay. Thyroid 8: 319-325.
10. Feldt-Rasmussen U, Schleusner H, Carayon P (1994) Meta-analysis evaluation of the impact of thyrotropin receptor antibodies on long term remission after medical therapy of Graves' disease. J Clin Endocrinol Metab 78: 98-102.
11. Maugendre D, Massart C (2001) Clinical value of a new TSH binding inhibitory activity assay using human TSH receptors in the follow-up of antithyroid drugtreated Graves' disease. Comparison with thyroid stimulating antibody bioassay. Clin Endocrinol 54: 89-96.
12. nd generation TRAK human assay did not improve prediction of relapse after antithyroid medical therapy of Graves' disease. Eur J Endocrinol 146: 173-177.
13. Kasagi K, Misaki T, Konishi J (2002) A sensitive solid-phase assay for TSH binding inhibitor immunoglobulins using recombinant human TSH receptor. Jpn J Med Pharm Sci 47: 305-310 (In Japanese).
14. Kashiwa T, Hidaka Y, Takano T, Tatsumi K, Izumi Y, Shimaoka Y, Tada H, Takeoka K, Amino N (2003) Practical treatment with minimal maintenance dose of anti-thyroid drugs for prediction of remission in Graves' disease. Endocr J 50: 45-49.
15. Shott M, Morgenthaler NG, Fritzen R, Feldkamp J, Willenberg HS, Scherbaum WA, Seissler J (2004) Levels of autoantibodies against human TSH receptor predict relapse of hyperthyroidism in Graves' disease. Horm Metab Res 36: 92-96.
16. Okamoto Y, Tanigawa S, Ishikawa K, Hamada N (2004) Indication of stopping antithyroid drug treatment for Graves' disease. Folia Endocrinol Jpn 80: 124 (abstract in Japanese).
17. Sasaki I, Kubota S, Ohe H, Fukada S, Kuma K, Miyauchi A (2004) Evaluation of high-sensitive TRAb levels to judge the cessation of ATD treatment for Graves' patients. Folia Endocrinol Jpn 80: 124 (abstract in Japanese).
18. Saiki Y, Ishihara T, Ikekubo K, Mori T (2005) Differences in TSH receptor binding and thyroid-stimulating properties between TSH and Graves' IgG. Slow-acting TSH receptor antibody moieties in Graves' sera affect assay data. Endocr J 52: 45-55.
19. Watanabe Y, Tahara K, Hirai A, Tada H, Kohn LD, Amino N (1997) Subtypes of anti-TSH receptor antibodies classified by various assays using CHO cells expressing wild-type, or chimeric human TSH receptor. Thyroid 7: 13-19.
20. Kim WB, Chung HK, Lee HK, Kohn LD, Tahara K, Cho B-Y (1997) Changes in epitopes for thyroidstimulating antibodies in Graves' disease sera during treatment of hyperthyroidism: therapeutic implications. J Clin Endocrinol Metab 82: 1953-1959.
21. Ueda Y, Sugawa H, Akamizu T, Okuda J, Ueda M, Kosugi S, Ohta C, Kihou Y, Mori T (1995) Thyroidstimulating antibodies in sera from patients with Graves' disease are heterogeneous in epitope recognition. Eur J Endocrinol 132: 62-68.
22. Sugawa H, Akamizu T, Kosugi S, Ueda Y, Ohta C, Okuda J, Mori T (1995) Presence of heterogeneous thyroid-stimulating antibodies in sera from individual Graves' patients as shown by synthesized thyrotropin receptor peptide application: evidence showing two independent epitopes and a possible recognition of two epitopic regions by one antibody molecule. Eur J Endocrinol 133: 283-293.
23. Sugawa H, Akamizu T, Inoue D, Okuda J, Mori T (1993) Production of clonal anti-thyroid stimulating hormone receptor antibody producing B cell lines using Epstein-Barr virus transformation. In: Nagataki S, Mori T, Torizuka K (eds) 80 years of Hashimoto Disease, Excerpta Medica, Amsterdam, 491-495.
24. Akamizu T, Matsuda F, Okuda J, Li H, Kanda H, Watanabe T, Honjo T, Mori T (1996) Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. J Immunol 157: 3148-3152.
25. Sanders J, Jeffreys J, Depraetere H, Richards T, Evans M, Kiddie A, Brereton K, Groenen M, Oda Y, Rees Smith B (2002) Thyroid stimulating monoclonal antibodies. Thyroid 12: 1043-1050.
26. Ando T, Latif R, Pritsker A, Moran T, Nagayama Y, Davies TF (2002) A monoclonal thyroid stimulating antibody. J Clin Invest 110: 1667-1674.
27. Costagliola S, Franssen JD, Bonomi M, Urizar E, Willnich M, Bergmann A, Vassart G (2002) Generation of a mouse monoclonal TSH receptor antibody with stimulating activity. Biochem Biophys Res Commun 299: 891-896.
28. Costagliola S, Vassart G (2002) Monoclonal antibodies with thyroid stimulating activity, at last. Thyroid 12: 1039-1041.
29. Minich WB, Lenzner C, Morgenthaler NG (2004) Antibodies to TSH receptor in thyroid autoimmune disease interact with monoclonal antibodies whose epitopes are broadly disrupted on the receptor. Clin Exp Endocrinol 136: 129-136.
30. Morgenthaler NG, Minich WB, Willnich M, Bogusch T, Hollidt JM, Weglohner W, Lenzner C, Bergman A (2003) Affinity purification and diagnostic use of TSH receptor autoantibodies from human serum. Mol Cell Endocrinol 212: 73-79.
31. Shering G, Smith BR (1982) An improved radioreceptor assay for TSH receptor antibodies. Clin Endocrinol (Oxf) 17: 409-414.
32. Mori T, Orgiazzi J (1995) TRAbs, when to measure? 1995, Presented at the 11th International Thyroid Conference, Toronto, Canada.
33. Instructions for the Cosmic TRAb II assay (2000) Cosmic Ltd, Tokyo, Japan.
34. th annual meeting of Japan Thyroid Association, Naha, Japan.