Investigative implications of the instability and metabolism of mebeverine

Journal of Analytical Toxicology

Volumn 30, Issue 2, 2006, Pages 91-97

  Elliott, Simon ^a   Burgess, Victoria ^a  

^a CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CITALOPRAM; MEBEVERINE;

ADULT; AQUEOUS SOLUTION; ARTICLE; AUTOPSY; BODY FLUID; CASE REPORT; DRUG OVERDOSE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; MASS SPECTROMETRY;

EID: 33644988847     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/30.2.91     Document Type: Article

References (9)

1. Mebeverine. In British National Formularly (BNF). British Medical Association and Royal Pharmaceutical Society of Great Britain, London, U.K., 2004, p 42.
2. R.G. Dickinson, P.V. Baker, M.E. Franklin, and W.D. Hooper. Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration. J. Pharm. Sci. 80(10): 952-957 (1991).
3. J. Kristinsson, I. Snorradottir, and M. Johannson. The metabolism of mebeverine in man: identification of urinary metabolites by gas chromathography/mass spectrometry. Pharmacol. Toxicol. 74(3): 174-180 (1994).
4. G. Hoogewijs and D.L. Maasart. Development of a standardised analysis strategy for basic drugs using ion-pair extraction and high-performance liquid chromatography. VIII. Method construction for the determination of mebeverine in tablets and biological fluids. J. Chromatogr. 377: 391-398 (1986).
5. T. Kraemer, J. Bickeboeller-Friedrich, and H.H. Maurer. On the metabolism of the amphetamine-derived antispasmodic drug mebeverine: gas chromatography-mass spectromtery studies on rat liver microsomes and on human urine. Drug Metab. Dispos. 28(3): 339-347 (2000).
6. T. Kraemer, R. Wennig, and H.H. Maurer. The antispasmodic drug mebeverine leads to positive amphetamine results by fluoresence polarization immunoassay (FPIA) - studies on the toxicological analysis of urine by FPIA and GC-MS. J. Anal. Toxicol. 25: 333-338 (2001).
7. A. Stockis, P.J.M. Guelen, and D. De Vos. Identification of mebeverine acid as the main circulating metabolite of mebeverine in man. J. Pharm. Biomed. Anal. 29(1-2): 335-340 (2002).
8. L.J. Tulich, J.L. Randall, G.R. Kelm, and K.R. Wehmeyer. Determination of two mebeverine metabolites, mebeverine alcohol and desmethylmebeverine alcohol, in human plasma by a dual stable isotope-based gas chromatographic-mass spectrometric method. J. Chromatogr. B 682(2): 273-281 (1996).
9. G. del Villar. A fatality involving mebeverine. Bull. Int. Assoc. Forensic Toxicol. 13(1-2): 23-24 (1977).