Determination of two mebeverine metabolites, mebeverine alcohol and desmethylmebeverine alcohol, in human plasma by a dual stable isotope-based gas chromatographic-mass spectrometric method

Journal of Chromatography B: Biomedical Applications

Volumn 682, Issue 2, 1996, Pages 273-281

  Tulich, Linda J ^a   Randall, Jared L ^a   Kelm, Gary R ^a   Wehmeyer, Kenneth R ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Desmethylmebeverine alcohol; Mebeverine; Mebeverine alcohol

Indexed keywords

BETA GLUCURONIDASE; COLOFAC; DESMETHYLMEBEVERINE ALCOHOL; DRUG METABOLITE; MEBEVERINE; MEBEVERINE ALCOHOL; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG DETERMINATION; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

EID: 0030581181     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4347(96)00039-4     Document Type: Article

References (10)

1. [1] H. Haddad and G. Devroede-Bertrand, Med. Clin. N. Am., 65 (1981) 1377.
2. [2] K.J. Ivey, Gastroenterology, 68 (1975) 1300.
3. [3] A.D. Hertog and J. Van den Akker, Eur. J. Pharmacol., 139 (1973) 353.
4. [4] K. Luttecke, Curr. Med. Res. Opin., 6 (1980) 437.
5. [5] C. Tasman-Jones, N.Z. Med. J., 77 (1973) 232.
6. [6] L. Capurso, M. Koch, M. Tarquini, A. Dezi, C. Papi and P. Fracasso, Clin. Trial J., 21 (1984) 285.
7. [7] G. Hoogewijs and D. L. Massart, J. Chromatogr., 377 (1986) 391.
8. [8] R.G. Dickinson, P.V. Baker, M.E. Frankilin and W.D. Hooper, J. Pharm. Sci., 80 (1991) 952.
9. [9] A.A. Al-Angary, S.H. Khidr, S.S. Abd-Elhady, M.A. Bayomi, G.M. Mahrous, Anal. Lett., 25 (1992) 1251.
10. [10] A. Eshra, Alex. J. Pharm. Sci., 6 (1992) 198.