Evaluating and managing hypogammaglobulinemia

Cleveland Clinic Journal of Medicine

Volumn 73, Issue 2, 2006, Pages 133-144

  Rose, M E ^a   Lang, David M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANTIBIOTIC AGENT; BACTERIUM ANTIBODY; CARBAMAZEPINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GOLD; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; PHENYTOIN; PLACEBO; PNEUMOCOCCUS VACCINE; SALAZOSULFAPYRIDINE; STEROID;

ACUTE KIDNEY FAILURE; ANTIBODY DETECTION; ASEPTIC MENINGITIS; BLOOD ANALYSIS; CANCER RISK; CELLULAR IMMUNITY; CHILL; CHRONIC LYMPHATIC LEUKEMIA; COMMON VARIABLE IMMUNODEFICIENCY; CONSULTATION; COUGHING; DRUG HYPERSENSITIVITY; DYSPNEA; ENZYME LINKED IMMUNOSORBENT ASSAY; FATIGUE; HEADACHE; HEMODIALYSIS; HOSPITALIZATION; HUMAN; HUMORAL IMMUNITY; HYPERTENSION; HYPOGAMMAGLOBULINEMIA; IMMUNOGLOBULIN A DEFICIENCY; IMMUNOGLOBULIN G DEFICIENCY; INFECTION SENSITIVITY; KIDNEY DISEASE; LABORATORY TEST; LOBAR PNEUMONIA; LYMPHOMA; MULTIPLE MYELOMA; MYALGIA; NAUSEA; NEPHELOMETRY; NONHODGKIN LYMPHOMA; PERITONEAL DIALYSIS; PHYSICAL STRESS; PROTEIN LOSING GASTROENTEROPATHY; RECURRENT DISEASE; RESPIRATORY TRACT INFECTION; REVIEW; STOMACH CANCER; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; THORAX RADIOGRAPHY; VIRUS INFECTION; AGAMMAGLOBULINEMIA; DIFFERENTIAL DIAGNOSIS;

AGAMMAGLOBULINEMIA; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS;

EID: 33644978345     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.73.2.133     Document Type: Review

References (62)

1. Cunningham-Rundles C. Clinical and immunologic analyses of 103 patients with common variable immunodefiency. J Clin Immunol 1989; 9:22-33.
2. Di Renzo M, Zhou Z, George I, Becker K, Cunningham-Rundles C. Enhanced apoptosis of T cells in common variable immunodefiency (CVID): role of defective CD28 co-stimulation. Clin Exp Immunol 2000; 120:503-511.
3. Kondratenko I, Amlot PL, Webster AD, Farrant J. Lack of specific antibody response in common variable immunodefiency (CVID) associated with failure in production of antigen-specific memory T cells. MRC Immunpdefiency Group. Clin Exp Immunol 1997; 108:9-13.
4. Vorechovsky I, Zetterquist H, Paganelli R, et al. Family and linkage of selective lgA defiency and common variable immunodefiency. Clin Immunol Immunopathol 1995; 77:185-192.
5. Schroeder HW Jr, Schroeder HW 3rd, Sheikh SM. The complex genetics of common variable immunodefiency. J Investig Med 2004; 52:90-103.
6. Baumgart KW, Britton WJ, Kemp A, French M, Roberton D. The spectrum of primary immunodefiency disorders in Australia. J Allergy Clin Immunol 1997; 100:415-423.
7. Kainulainen L, Nikoskelainen J, Ruuskanen O. Diagnostic findings in 95 Finnish patients with common variable immunodefiency. J Clin Immunol 2001; 21:145-149.
8. Pettit SJ, Bourne H, Spickett GP. Survey of infection in patients receiving antibody replacement treatment for immune defiency. J Clin Pathol 2002; 55:577-580.
9. Ekdahl K, Braconier JH, Svanborg C. Immunoglobulin defiencies and impaired immune response to polsaccharide antigens in adult patients with recurrent community-acquired pneumonia. Scand J Infect Dis 1997; 29:401-407.
10. Curtin JJ, Murray JG, Apthorp LA, Franz AM, Webster AD. Mediastinal lymph node enlargement and splenomegaly in primary hypogammaglobulinemia. Clin Radiol 1995; 50:489-491.
11. Cunningham-Rundles C, Bodian C. Common variable immunodefiency: clinical and immunological features of 248 patients. Clin Immunol 1999; 92:34-48.
12. Michel M, Chanet V, Galicier L, et al. Autoimmune thrombocytopenic purpura and common variable immunodefiency: analysis of 21 cases and review of the literature. Medicine (Baltimore) 2004; 83:254-263.
13. Uluhan A, Sager D, Jasin HE. Juvenile rheumatoid arthritis and common variable hypogammaglobulinemia. J Rheumatol 1998; 25:1205-1210.
14. Swaak AJ, van den Brink HG. Common variable immunodeficiency in a patient with systemic lupus erythematosus. Lupus 1996; 5:242-246.
15. Stead A, Douglas JG, Broadfoot CJ, Kaminski ER, Herriot R. Humoral immunity and bronchiectasis. Clin Exp Immunol 2002; 130:325-330.
16. Popa V, Colby TV, Reich SB. Pulmonary interstitial disease in Ig deficiency. Chest 2002; 122:1594-1603.
17. Berger M. A history of immune globulin therapy, from the Harvard crash program to monoclonal antibodies. Curr Allergy Asthma Rep 2002; 2:368-378.
18. Chapel HM, Spickett GP, Ericson D, Engl W, Eibl MM, Bjorkander J. The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy. J Clin Immunol 2000; 20:94-100.
19. Sewell WA, Buckland M, Jolles SR. Therapeutic strategies in common variable immunodeficiency. Drugs 2003; 63:1359-1371.
20. Bjoro K, Froland SS, Yun Z, Samdal HH, Haaland T. Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin. N Engl J Med 1994, 331:1607-1611.
21. Chandra S, Cavanaugh JE, Lin CM, et al. Virus reduction in the preparation of intravenous immune globulin: in vitro experiments. Transfusion 1999, 39:249-257.
22. Lemm G. Composition and properties of IVIg preparations that affect tolerability and therapeutic efficacy. Neurology 2002; 59(suppl 6):S28-S32.
23. Sekul EA, Cupler EJ, Dalakas MC. Aseptic meningitis associated with highdose intravenous immunoglobulin: frequency and risk factors. Ann Intern Med 1994; 121:259-262.
24. Sati HI, Ahya R, Watson HG. Incidence and associations of acute renal failure complicating high-dose intravenous immunoglobulin therapy. Br J Haematol 2001; 113:556-557.
25. Cunningham-Rundles C, Zhou Z, Mankarious S, Courter S. Long-term use of IgA-depleted intravenous immunoglobulin in immunodeficient subjects with IgA antibodies. J Clin Immunol 1993; 13:272-278.
26. Johnson ML, Keeton LG, Zhu ZB, Volanakis JE, Cooper MD, Schroeder HW Jr. Age-related changes in serum immunoglobulins in patients with familial IgA deficiency and common variable immunodeficiency (CVID). Clin Exp Immunol 1997; 108:477-483.
27. Mila Llambi J, Etxagibel Galdos A, Matamoros Flori N. The Spanish Registry of Primary Immunodeficiencies (REDIP) [in Spanish]. Allergol Immunopathol (Madr) 2001; 29:122-125.
28. Kanoh T, Mizumoto T, Yasuda N, et al. Selective IgA deficiency in Japanese blood donors: frequency and statistical analysis. Vox Sang 1986, 50:81-86
29. Weber-Mzell D, Kotanko P, Hauer AC, et al. Gender, age and seasonal effects on IgA deficiency: a study of 7293 Caucasians. Eur J Clin Invest 2004; 34:224-228.
30. Curzio M, Bernasconi G, Gullotta R, Ceriani A, Sala G. Association of ulcerative colitis, sclerosing cholangitis and cholangiocarcinoma in a patient with IgA deficiency. Endoscopy 1985; 17:123-125
31. Hermaszewski RA, Ratnavel RC, Denman DJ, Denman AM, Webster AD. Immunodeficiency and lymphoproliferative disorders. Baillieres Clin Rheumatol 1991; 5:277-300.
32. French MA, Denis KA, Dawkins R, Peter JB. Severity of infections in IgA deficiency: correlation with decreased serum antibodies to pneumococcal polysaccharides and decreased serum IgG2 and/or IgG4. Clin Exp Immunol 1995; 100:47-53.
33. Gross S, Blaiss MS, Herrod HG. Role of immunoglobulin subclass and specific antibody determinations in the evaluation of recurrent infection in children. J Pediatr 1992; 121:516-522.
34. Ekdahl K, Braconier JH, Svanborg C. Immunoglobulin deficiencies and impaired immune response to polysaccharide antigens in adult patients with recurrent community-acquired pneumonia. Scand J Infect Dis 1997; 29:401-407.
35. Alper CA, Xu J, Cosmopoulos K, et al. Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency. J Clin Immunol 2003; 23:297-305.
36. Soderstrom T, Soderstrom R, Enskog A. Immunoglobulin subclasses and prophylactic use of immunoglobulin in immunoglobulin G subclass deficiency. Cancer 1991; 68(6 suppl):1426-1429.
37. Follin P, Ulanova M, Hahn-Zoric M, Hanson LA. Invasive Haemophilus influenza type b (Hib) infection in an adult patient with a selective deficiency of antibody to the Hib capsular polysaccharide. Clin Infect Dis 1997; 25:915-917.
38. Sorensen RU, Leiva LE, Javier FC 3rd, et al. Influence of age on the response to Streptococcus pneumoniae vaccine in patients with recurrent infections and normal immunoglobulin concentrations. J Allergy Clin Immunol 1998; 102:215-221.
39. Go ES, Ballas ZK. Anti-pneumococcal antibody response in normal subjects: a meta-analysis. J Allergy Clin Immunol 1996; 98:205-215.
40. Zora JA, Silk HJ, Tinkelman DG. Evaluation of postimmunization pneumococcal titers in children with recurrent infections and normal levels of immunoglobulin. Ann Allergy 1993; 70:283-288.
41. Leon F, Olivencia P, Rodriquez-Pena R, et al. Clinical and immunological features of adult-onset generalized autoimmune gut disorder. Am J Gastroenterol 2004; 99:1563-1571.
42. Fuss U, Strober W, Cuccherini BA, et al. Intestinal lymphangiectasia, a disease characterized by selective loss of naive CD45RA+ lymphocytes into the gastrointestinal tract. Eur J Immunol 1998; 28:4275-4285.
43. Lester LA, Rothberg RM, Krantman HJ, Shermeta DW. Intestinal lymphangiectasia and bilateral pleural effusions: effect of dietary therapy and surgical intervention on immunologic and pulmonary parameters. J Allergy Clin Immunol 1986; 78:891-897.
44. De Giacomo C, Maggiore G, Scotta MS, Ugazio AG. Administration of intravenous immunoglobulin in two children with hypogammaglobulinemia due to protein losing enteropathy. Clin Exp Immunol 1985; 60:447-448.
45. Fikrig SM, Schiffman G, Phillipp JC, Moel DI. Antibody response to capsular polysaccharide vaccine of streptococcus pneumoniae in patients with nephrotic syndrome. J Infect Dis 1978; 137:818-821.
46. Ogi M, Yokoyama H, Tomosugi N, et al. Risk factors for infection and immunoglobulin replacement therapy in adult nephrotic syndrome. Am J Kidney Dis 1994; 24:427-436.
47. Neu AM, Lederman HM, Fivush BA. Hypogammaglobulinemia and fatal sepsis in an infant maintained on peritoneal dialysis. Pediatr Nephrol 1993; 7:455-456.
48. Kuo MC, Hwang SJ, Chang JM, Tsai JC, Tsai JH, Lai YH. Recurrent infections in haemodialysis patients - do not forget selective immunoglobulin A deficiency. Nephrol Dial Transplant 1998; 13:3220-3222.
49. Aittoniemi J, Miettinen A, Laine S, et al. Opsonising immunoglobulins and mannan-binding lectin in chronic lymphocytic leukemia. Leuk Lymphoma 1999; 34:381-385.
50. Castellano G, Moreno D, Galvao O, et al. Malignant lymphoma of jejunum with common variable hypogammaglobulinemia and diffuse nodular hyperplasia of the small intestine. A case study and literature review. J Clin Gastroenterol 1992; 15:128-135.
51. Perri RT, Oken MM, Kay NE. Enhanced T cell suppression is directed toward sensitive circulating B cells in multiple myeloma. J Lab Clin Med 1982; 99:512-519.
52. Tsiodras S, Samonis G, Keating MJ, Kontoyiannis DP. Infection and immunity in chronic lymphocytic leukemia. Mayo Clin Proc 2000; 75:1039-1054.
53. Moreno-Ancillo A, Cosmes Martin PM, Dominquez-Noche C, et al. Carbamazepine induced transient monoclonal gammopathy and immunodeficiency. Allergol Immunopathol (Madr) 2004; 32:86-88.
54. Boyum A, Wiik P, Gustavsson E, et al. The effect of strenuous exercise, calorie deficiency and sleep deprivation on white blood cells, plasma immunoglobulins and cytokines. Scand J Immunol 1996; 43:228-235.
55. Stiehm ER. Human intravenous immunoglobulin in primary and secondary antibody deficiencies. Pediatr Infect Dis J 1997; 16:696-707.
56. Farr M, Tunn E, Bacon PA, Smith DH. Hypogammaglobulinaemia and thrombocytopenia associated with sulphasalazine therapy in rheumatoid arthritis. Ann Rheum Dis 1985; 44:723-724.
57. Snowden N, Dietch DM, Teh LS, Hilton RC, Haeney MR. Antibody deficiency associated with gold treatment: natural history and management in 22 patients. Ann Rheum Dis 1996; 55:616-621.
58. Hamilos DL, Young RM, Peter JB, Agopian MS, Ikle DN, Barka N. Hypogammaglobulinemia in asthmatic patients. Ann Allergy 1992; 68:472-481.
59. Travin M, Macris NT, Block JM, Schwimmer D. Reversible common variable immunodeficiency syndrome induced by phenytoin. Arch Intern Med 1989; 149:1421-1422.
60. Braconier JH. Reversible total IgA deficiency associated with phenytoin treatment. Scand J Infect Dis 1999; 31:515-516.
61. Yesilova Z, Ozata M, Kocar IH, et al. The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2000; 85:66-70.
62. Reid VL, Gleeson M, Williams N, Clancy RL. Clinical investigation of athletes with persistent fatigue and/or recurrent infections. Br J Sports Med 2004; 38:42-45.