Anti-inflammatory and antioxidant activities of Randia hebecarpa and major constituents

Pharmaceutical Biology

Volumn 44, Issue 1, 2006, Pages 7-9

  Nazari, Anelise S ^a   Dias, Suziane A ^a   Da Costa, Willian F ^a   Bersani Amado, Ciomar A ^a   Vidotti, Gentil J ^a   De Souza, Maria C ^a   Sarragiotto, Maria H ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Anti inflammatory activity; Flavonoids; Free radical scavenging activity; Lipid peroxidation inhibition; Randia hebecarpa; Saponins

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETIC ACID ETHYL ESTER; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BUTYLCRESOL; CARBOHYDRATE DERIVATIVE; CARRAGEENAN; CINCHOLIC ACID 3 O BETA DEXTRO QUINOVOPYRANOSYL 28 O BETA DEXTRO GLUCOPYRANOSIDE; DEXTRAN; KAEMPFEROL 3 O ALPHA LEVO RHAMNOSYL(1-6) BETA DEXTRO GALACTOSYL 7 O ALPHA LEVO RHAMNOSIDE; KAEMPFEROL 3 O BETA DEXTRO GALACTOSIDE; KAEMPFEROL 3,7 O ALPHA LEVO DIRHAMNOSIDE; LINOLEIC ACID; MANNITOL; METHANOL; MYRICETIN 3 O ALPHA LEVO RHAMNOSIDE; PLANT EXTRACT; QUERCETIN 3 O BETA DEXTRO GALACTOSIDE; QUINOVIC ACID 3 O BETA DEXTRO QUINOVOPYRANOSYL 28 O BETA DEXTRO GLUCOPYRANOSIDE; RANDIA HEBECARPA EXTRACT; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG SCREENING; FRACTIONATION; LIPID PEROXIDATION; MEDICINAL PLANT; NONHUMAN; PAW EDEMA; PLANT LEAF; RANDIA HEBECARPA; RAT; RUBIACEAE;

ANIMALIA; RANDIA HEBECARPA; RUBIACEAE;

EID: 33644974340     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200500496504     Document Type: Article

References (16)

1. Arriaga FJ, Rumbero A, Vasquez P (1990): Two triterpene glycosides from Isertia haenkeana. Phytochemistry 29: 209-213.
2. Agrawal PK, Bansal MC (1989): Flavonoid glycosides. In: Agrawal PK, ed., Carbon-13 NMR of Flavonoids. New York, Elsevier, pp. 334-337.
3. Cho EJ, Yokozawa T, Rhyu DY, Kim SC, Shibahara N, Park JC (2003): Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical. Phytomedicine 10: 544-551.
4. Dubois MA, Benze S, Wagner H (1990): New biologically active triterpene saponins from Randia dumetorum. Planta Med 56: 451-455.
5. Hamerski L, Furlan M, Silva DHS, Cavalheiro AJ, Eberlin MN, Tómasela DM, Bolzani VS (2003): Iridoid glucosides from Randia spinosa (Rubiaceae). Phytochemistry 63: 397-400.
6. Hopia A, Heinonen M (1999): Antioxidant activity of flavonol aglycones and their glycosides in methyl linoleate. J Am Oil Chem Soc 76: 139-144.
7. Jansakul C, Intarit K, Itharat A, Phadungcharoen T, Ruangrungsi, N, Merica A, Lange GL (1999): Biological activity of crude extract and saponin pseudogin-seniside-RT1 derived from the fruit of Randia siamensis. Pharm Biol 37: 42-45.
8. Osawa T, Namiki K (1981): A novel type of antioxidant isolated from leaf wax of Eucalyptus leaves. Agr Biol Chem 45: 735-739.
9. Recio MC, Giner RM, Mnez S, Rios JL (1994): Structural considerations on the iridoids as ani-inflammatory agents. Planta Med 60: 232-234.
10. Rotelli AE, Guardia T, Juarez AO, Rocha NE, Pelzer LE (2003): Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res 48: 601-606.
11. Sahpaz S, Gupta MP, Hostettman K (2000): Triterpene saponins from Randia formosa. Phytochemistry 54: 77-84.
12. Sati OP, Bahuguna S, Uniyal S, Bhakuni DS (1989): Triterpenoid saponins from Randia uliginosa. Phytochemistry 28: 575-577.
13. Tanaka I (2001): Plantas medicinais de uso popular na planície de inundação do alto rio Paraná, região de Porto Rico (Paraná e Mato Grosso do Sul). MSc thesis, Postgraduate Programme in Ecologia de Ambientes Aquáticos Continentais, Universidade Estadual de Maringá, Paraná, Brazil.
14. Useato S, Ali E, Nishimura H, Kawamura I, Inouye H (1982): Studis on monoterpene glucosides and related natural products. 4 Iridoids from Randia canrhioides. Phytochemistry 21: 353-357.
15. Winter C, Risley E, Nuss G (1962): Carrageenan-induced edema in hind paw of rats as an assay for anti-inflammatory drug. Proc Soc Exp Biol Med 111: 207-210.
16. Yahara S, Kohjyouma M, Kohoda H (2000): Flavonoid glycosides and saponins from Astragalus shikokianus. Phytochemistry 53: 469-471.