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Judging from the recent claim that it is the amino group that is responsible for the binding of DNA with aminoalkylated silica nanoparticles (He, X,-x.; Wang, K.; Tan, W.; Liu, B.; Lin, X.; He, C.; Li, D.; Hung, S.; Li, J. J. Am. Chem. Soc. 2003, 125, 7168-7169), the present cerasome-plasmid complexation must be primarily driven by electrostatic (N-P) forces, although contribution of the Si-O-Si and Si-OH moieties could not be ruled out. Calculation suggests that one cerasome binds ∼3 molecules of plasmid pGL3 (see SI).
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