Anomalous regulation of β-adrenoceptor signaling in brain regions of the newborn rat

Brain Research

Volumn 1077, Issue 1, 2006, Pages 54-58

  Slotkin, Theodore A ^a   Seidler, Frederic J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

adrenoceptor; Adenylyl cyclase; Desensitization; Dopamine; Terbutaline

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; DOPAMINE; DOPAMINE RECEPTOR; FORSKOLIN; ISOPRENALINE; TERBUTALINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN STEM; CATALYSIS; CELL MEMBRANE; CEREBELLUM; CONTROLLED STUDY; DRUG EFFECT; FOREBRAIN; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; ANIMALS, NEWBORN; BRAIN; DOWN-REGULATION; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; TERBUTALINE; UP-REGULATION;

ANIMALIA;

EID: 33644951715     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.01.047     Document Type: Article

References (32)

1. J.E. Aldridge, A. Meyer, F.J. Seidler, and T.A. Slotkin Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions Toxicol. Appl. Pharmacol. 203 2005 134 144
2. J.T. Auman, F.J. Seidler, C.A. Tate, and T.A. Slotkin Are developing β-adrenoceptors able to desensitize? Acute and chronic effects of β-agonists in neonatal heart and liver Am. J. Physiol. 283 2002 R205 R217
3. O. Barochovsky, and A.J. Patel Effect of central nervous system acting drugs on brain cell replication in vitro Neurochem. Res. 7 1982 1059 1074
4. R.B. Clark, J. Friedman, R.A. Dixon, and C.D. Strader Identification of a specific site required for rapid heterologous desensitization of the β-adrenergic receptor by cAMP-dependent protein kinase Mol. Pharmacol. 36 1989 343 348
5. M.C. Garofolo, F.J. Seidler, M.M. Cousins, C.A. Tate, D. Qiao, and T.A. Slotkin Developmental toxicity of terbutaline: critical periods for sex-selective effects on macromolecules and DNA synthesis in rat brain, heart, and liver Brain Res. Bull. 59 2003 319 329
6. R.L. Goldenberg The management of preterm labor Obstet. Gynecol. 100 2002 1020 1037
7. P.S. Goldman, A.J. DeMaggio, M.F. Hoekstra, and R.H. Goodman The β-adrenergic receptor kinase interacts with the amino terminus of the G protein b subunit Biochem. Biophys. Res. Commun. 240 1997 425 429
8. G. Iwami, J. Kawabe, T. Ebina, P.J. Cannon, C.J. Homcy, and Y. Ishikawa Regulation of adenylyl cyclase by protein kinase A J. Biol. Chem. 270 1995 12481 12484
9. E.M. Kudlacz, H.A. Navarro, J.P. Eylers, S.S. Dobbins, S.E. Lappi, and T.A. Slotkin Selective linkage of β-adrenergic receptors to functional responses in developing rat lung and liver: phosphatidic acid phosphatase, ornithine decarboxylase and lung liquid reabsorption J. Dev. Physiol. 12 1989 129 134
10. E.M. Kudlacz, H.A. Navarro, and T.A. Slotkin Phosphatidic acid phosphatase in neonatal rat lung: effects of prenatal dexamethasone or terbutaline treatment on basal activity and on responsiveness to beta adrenergic stimulation J. Pharmacol. Exp. Ther. 250 1989 236 240
11. J.H. Kwon, E.M. Eves, S. Farrell, J. Segovia, A.J. Tobin, B.H. Wainer, and M. Downen β-Adrenergic receptor activation promotes process outgrowth in an embryonic rat basal forebrain cell line and in primary neurons Eur. J. Neurosci. 8 1996 2042 2055
12. F. Lam, J. Elliott, J.S. Jones, M. Katz, R.A. Knuppel, J. Morrison, R. Newman, J. Phelan, and R. Willcourt Clinical issues surrounding the use of terbutaline sulfate for preterm labor Obstet. Gynecol. Surv. 53 1998 S85 S95
13. F. Lam, N.K. Bergauer, D. Jacques, S.K. Coleman, and G.J. Stanziano Clinical and cost-effectiveness of continuous subcutaneous terbutaline versus oral tocolytics for treatment of recurrent preterm labor in twin gestations J. Perinatol. 21 2001 444 450
14. F. Lam, N.B. Istwan, D. Jacques, S.K. Coleman, and G.J. Stanziano Managing perinatal outcomes: the clinical benefit and cost-effectiveness of pharmacologic treatment of recurrent preterm labor Managed Care 12 2003 39 46
15. Y.C. Ma, and X.Y. Huang Novel signaling pathway through the β-adrenergic receptor Trends Cardiovasc. Med. 12 2002 46 49
16. F. Mayor, P. Penela, and A. Ruiz-Gomez Role of G protein-coupled receptor kinase 2 and arrestins in β-adrenergic receptor internalization Trends Cardiovasc. Med. 8 1998 234 240
17. A. Meyer, F.J. Seidler, J.E. Aldridge, and T.A. Slotkin Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide, chlorpyrifos Toxicol. Appl. Pharmacol. 203 2005 154 166
18. H.A. Navarro, E.M. Kudlacz, and T.A. Slotkin Control of adenylate cyclase activity in developing rat heart and liver: effects of prenatal exposure to terbutaline or dexamethasone Biol. Neonate 60 1991 127 136
19. K. Palczewski, and J.L. Benovic G-protein-coupled receptor kinases Trends Biochem. Sci. 16 1991 387 391
20. E. Popovik, and L.W. Haynes Survival and mitogenesis of neuroepithelial cells are influenced by noradrenergic but not cholinergic innervation in cultured embryonic rat neopallium Brain Res. 853 2000 227 235
21. R.T. Premont, O. Jacobowitz, and R. Iyengar Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by Gs in heterologous desensitization: a role for adenosine 3′,5′-monophosphate-dependent phosphorylation Endocrinology 131 1992 2774 2784
22. M.C. Rhodes, F.J. Seidler, A. Abdel-Rahman, C.A. Tate, A. Nyska, H.L. Rincavage, and T.A. Slotkin Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus and somatosensory cortex J. Pharmacol. Exp. Ther. 308 2004 529 537
23. M.C. Rhodes, F.J. Seidler, D. Qiao, C.A. Tate, M.M. Cousins, and T.A. Slotkin Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats Toxicol. Appl. Pharmacol. 195 2004 203 217
24. J.P. Schwartz, and N. Nishiyama Neurotrophic factor gene expression in astrocytes during development and following injury Brain Res. Bull. 35 1994 403 407
25. K.B. Seamon, and J.W. Daly Forskolin: its biological and chemical properties Adv. Cycl. Nucleotide Protein Phosphoryl. Res. 20 1986 1 150
26. T.A. Slotkin, C.A. Tate, M.M. Cousins, and F.J. Seidler β-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline Dev. Brain Res. 131 2001 113 125
27. T.A. Slotkin, J.T. Auman, and F.J. Seidler Ontogenesis of β-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs J. Pharmacol. Exp. Ther. 306 2003 1 7
28. T.A. Slotkin, C.A. Oliver, and F.J. Seidler Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination Dev. Brain Res. 157 2005 172 180
29. C.M. Tan, D.J. Kelvin, D.W. Litchfield, and R.D. Feldman Tyrosine kinase-mediated serine phosphorylation of adenylyl cyclase and enhancement of adenylyl cyclase activity FASEB J. 12 1998 A154
30. K. Tegner, H.T. Nilsson, C.G.A. Persson, K. Persson, and Å. Ryrfeldt Elimination pathways of terbutaline Eur. J. Respir. Dis. 65 Suppl. 134 1984 93 100
31. P. Tsao, and M. von Zastrow Downregulation of G-protein-coupled receptors Curr. Opin. Neurobiol. 10 2000 365 369
32. A. Yamashita, T. Kurokawa, Y. Une, and S. Ishibashi Reduction in the stability of the Gs-catalytic unit complex of adenylate cyclase in isoproterenol-induced heterologous desensitization Eur. J. Pharmacol. 159 1989 247 256