3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances

European Journal of Medicinal Chemistry

Volumn 41, Issue 2, 2006, Pages 176-191

  Mahboobi, Siavosh ^a   Eichhorn, Emerich ^a   Popp, Alfred ^a   Sellmer, Andreas ^a   Elz, Sigurd ^a   Möllmann, Ute ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Antibacterial; Indole derivatives; Mycobacterium smegmatis; Resistant Staphylococcus aureus; SAR study

Indexed keywords

1 METHYL 3 BROMO 4 (1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 (2 BUTYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 (2 ETHYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 (2 HEPTYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 (2 HEXYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 (2 METHYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 (2 PENTYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 (2 PHENYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 (2 PROPYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 [2 (2 METHOXYPHENYL) 1H 3 INDOLYL] 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 [2 (3 METHOXYPHENYL) 1H 3 INDOLYL] 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 1 METHYL 3 BROMO 4 [2 (4 METHOXYPHENYL) 1H 3 INDOLYL] 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 3 [3 (4 BROMO 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE 3 YL) 1H 2 INDOLYL] N (2 METHYLPHENYL)PROPIONYLAMIDE; 3 BROMO 4 (1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 3 BROMO 4 (2 BUTYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 3 BROMO 4 (2 ETHYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 3 BROMO 4 (2 METHYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 3 BROMO 4 (2 PENTYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 3 BROMO 4 (2 PROPYL 1H 3 INDOLYL) 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE; 4 [3 (4 BROMO 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE 3 YL) 1H 2 INDOLYL] N (2 METHYLPHENYL)BUTANOYLAMIDE; 5 [3 (4 BROMO 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE 3 YL) 1H 2 INDOLYL] N (2 METHYLPHENYL)PENTANOYLAMIDE; 6 [3 (4 BROMO 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE 3 YL) 1H 2 INDOLYL] N (2 METHYLPHENYL)HEXANOYLAMIDE; 7 [3 (4 BROMO 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE 3 YL) 1H 2 INDOLYL] N (2 METHYLPHENYL)HEPTANOYLAMIDE; 8 [3 (4 BROMO 2,5 DIHYDRO 1H 2,5 PYRROLEDIONE 3 YL) 1H 2 INDOLYL] N (2 METHYLPHENYL)OCTANOYLAMIDE; ANTIINFECTIVE AGENT; CIPROFLOXACIN; DOXYCYCLINE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; DOXYCYCLINE; DRUG RESISTANCE, MICROBIAL; GRAM-POSITIVE BACTERIA; INDOLES; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM SMEGMATIS; PYRROLES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN;

EID: 33644944497     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.10.006     Document Type: Article

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