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Volumn 17, Issue 3, 2006, Pages 503-509

Repeated intravenous injection of recombinant human hepatocyte growth factor ameliorates liver cirrhosis but causes albuminuria in rats

Author keywords

Albuminuria; Hepatocyte growth factor; Liver cirrhosis; Pharmacokinetics

Indexed keywords

ALANINE AMINOTRANSFERASE; DIMETHYLNITROSAMINE; RECOMBINANT PROTEIN; SCATTER FACTOR; SERUM ALBUMIN;

EID: 33644940876     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.3.503     Document Type: Article
Times cited : (30)

References (49)
  • 1
    • 0022453539 scopus 로고
    • Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure
    • Gohda E, Tsubouchi H, Nakayama H, et al: Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure. Exp Cell Res 166: 139-150, 1986.
    • (1986) Exp Cell Res , vol.166 , pp. 139-150
    • Gohda, E.1    Tsubouchi, H.2    Nakayama, H.3
  • 3
    • 0025973778 scopus 로고
    • Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay
    • Tsubouchi H, Niitani Y, Hirono S, et al: Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay. Hepatology 13: 1-5, 1991.
    • (1991) Hepatology , vol.13 , pp. 1-5
    • Tsubouchi, H.1    Niitani, Y.2    Hirono, S.3
  • 4
    • 0026763010 scopus 로고
    • Prediction of outcome in fulminant hepatic failure by serum human hepatocyte growth factor
    • Tsubouchi H, Kawakami S, Hirono S, et al: Prediction of outcome in fulminant hepatic failure by serum human hepatocyte growth factor. Lancet 340: 307, 1992.
    • (1992) Lancet , vol.340 , pp. 307
    • Tsubouchi, H.1    Kawakami, S.2    Hirono, S.3
  • 5
    • 0025122144 scopus 로고
    • Liver regeneration: Molecular mechanisms of growth control
    • Michalopoulos GK: Liver regeneration: molecular mechanisms of growth control. FASEB J 4: 176-185, 1990.
    • (1990) FASEB J , vol.4 , pp. 176-185
    • Michalopoulos, G.K.1
  • 6
    • 0028095407 scopus 로고
    • Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell proliferation and migration
    • DOI 10.1006/bbrc.1994.1987
    • Dignass AU, Lynch-Devaney K and Podolsky DK: Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell proliferation and migration. Biochem Biophys Res Commun 202: 701-709, 1994. (Pubitemid 24259271)
    • (1994) Biochemical and Biophysical Research Communications , vol.202 , Issue.2 , pp. 701-709
    • Dignass, A.U.1    Lynch-Devaney, K.2    Podolsky, D.K.3
  • 7
    • 0026722243 scopus 로고
    • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
    • Bussolino F, Di Renzo MF, Ziche M, et al: Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 119: 629-641, 1992.
    • (1992) J Cell Biol , vol.119 , pp. 629-641
    • Bussolino, F.1    Di Renzo, M.F.2    Ziche, M.3
  • 8
    • 0028999868 scopus 로고
    • The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis
    • Zarneger R and Michalopoulos GK: The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis. J Cell Biol 129: 1177-1180, 1995.
    • (1995) J Cell Biol , vol.129 , pp. 1177-1180
    • Zarneger, R.1    Michalopoulos, G.K.2
  • 9
    • 0027375855 scopus 로고
    • Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats
    • DOI 10.1016/0270-9139(93)90237-H
    • Fujiwara K, Nagoshi S, Ohno A, et al: Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats. Hepatology 18: 1443-1449, 1993. (Pubitemid 23348435)
    • (1993) Hepatology , vol.18 , Issue.6 , pp. 1443-1449
    • Fujiwara, K.1    Nagoshi, S.2    Ohno, A.3    Hirata, K.4    Ohta, Y.5    Mochida, S.6    Tomiya, T.7    Higashio, K.8    Kurokawa, K.9
  • 10
    • 0026484294 scopus 로고
    • Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo
    • Ishiki Y, Ohnishi H, Muto Y, Matsumoto K and Nakamura T: Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo. Hepatology 16: 1227-1235, 1992.
    • (1992) Hepatology , vol.16 , pp. 1227-1235
    • Ishiki, Y.1    Ohnishi, H.2    Muto, Y.3    Matsumoto, K.4    Nakamura, T.5
  • 11
    • 0029011973 scopus 로고
    • Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats
    • Ishii T, Sato M, Sudo K, et al: Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats. J Biochem 117: 1105-1112, 1995.
    • (1995) J Biochem , vol.117 , pp. 1105-1112
    • Ishii, T.1    Sato, M.2    Sudo, K.3
  • 12
    • 0027331503 scopus 로고
    • Transforming growth factor-alpha expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-alpha and hepatocyte growth factor
    • DOI 10.1016/0270-9139(93)90234-E
    • Webber EM, Fitzgerald MJ, Brown PI, Barlett MH and Fausto N: Transforming growth factor-α expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-α and hepatocyte growth factor. Hepatology 18: 1422-1431, 1993. (Pubitemid 2003757)
    • (1993) Hepatology , vol.18 , Issue.6 , pp. 1422-1431
    • Webber, E.M.1    FitzGerald, M.J.2    Brown, P.I.3    Bartlett, M.H.4    Fausto, N.5
  • 13
    • 0034811231 scopus 로고    scopus 로고
    • Additive and inhibitory effects of simultaneous treatment with growth factors on DNA synthesis through MAPK pathway and G1 cyclins in rat hepatocytes
    • Moriuchi A, Hirono S, Ido A, et al: Additive and inhibitory effects of simultaneous treatment with growth factors on DNA synthesis through MAPK pathway and G1 cyclins in rat hepatocytes. Biochem Biophys Res Commun 280: 368-273, 2001.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 368-1273
    • Moriuchi, A.1    Hirono, S.2    Ido, A.3
  • 14
    • 0030715686 scopus 로고    scopus 로고
    • Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice
    • Okano J, Shiota G and Kawasaki H: Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice. Hepatology 26: 1241-1249, 1997.
    • (1997) Hepatology , vol.26 , pp. 1241-1249
    • Okano, J.1    Shiota, G.2    Kawasaki, H.3
  • 15
  • 17
    • 0033067527 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice
    • DOI 10.1002/hep.510300102
    • Kosai K, Matsumoto K, Funakoshi H and Nakamura T: Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure. Hepatology 30: 151-159, 1999. (Pubitemid 29300581)
    • (1999) Hepatology , vol.30 , Issue.1 , pp. 151-159
    • Kosai, K.-I.1    Matsumoto, K.2    Funakoshi, H.3    Nakamura, T.4
  • 18
    • 0032981689 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects mice against anti-Fas antibody-induced death
    • Mori I, Tsuchida A, Taiji M and Noguchi H: Hepatocyte growth factor protects mice against anti-Fas antibody-induced death. Med Sci Res 27: 355-359, 1999. (Pubitemid 29253640)
    • (1999) Medical Science Research , vol.27 , Issue.5 , pp. 355-359
    • Mori, I.1    Tsuchida, A.2    Taiji, M.3    Noguchi, H.4
  • 19
    • 0034687536 scopus 로고    scopus 로고
    • Adenovirus-mediated hepatocyte growth factor gene transfer prevents lethal liver failure in rats
    • Nomi T, Shiota G, Isono M, Sato K and Kawasaki H: Adenovirus-mediated hepatocyte growth factor gene transfer prevents lethal liver failure in rats. Biochem Biophys Res Commun 278: 338-343, 2000.
    • (2000) Biochem Biophys Res Commun , vol.278 , pp. 338-343
    • Nomi, T.1    Shiota, G.2    Isono, M.3    Sato, K.4    Kawasaki, H.5
  • 20
    • 0036278439 scopus 로고    scopus 로고
    • Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation
    • DOI 10.1136/gut.50.4.558
    • Xue F, Takahara T, Yata Y, et al: Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation. Gut 50: 558-562, 2002. (Pubitemid 34638878)
    • (2002) Gut , vol.50 , Issue.4 , pp. 558-562
    • Xue, F.1    Takahara, T.2    Yata, Y.3    Minemura, M.4    Morioka, C.Y.5    Takahara, S.6    Yamato, E.7    Dono, K.8    Watanabe, A.9
  • 21
    • 0029817895 scopus 로고    scopus 로고
    • Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats
    • Yasuda H, Imai E, Shiota A, Fujise N, Morinaga T and Higashio K: Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats. Hepatology 24: 636-642, 1996.
    • (1996) Hepatology , vol.24 , pp. 636-642
    • Yasuda, H.1    Imai, E.2    Shiota, A.3    Fujise, N.4    Morinaga, T.5    Higashio, K.6
  • 22
    • 0030915038 scopus 로고    scopus 로고
    • Prevention and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis
    • Matsuda Y, Matsumoto K, Yamada A, et al: Prevention and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis. Hepatology 26: 81-89, 1997.
    • (1997) Hepatology , vol.26 , pp. 81-89
    • Matsuda, Y.1    Matsumoto, K.2    Yamada, A.3
  • 24
    • 0033977472 scopus 로고    scopus 로고
    • The decrease in total collagen fibers in the liver by hepatocyte growth factor after formation of cirrhosis induced thioacetamide
    • Sato M, Kakubari M, Kawamura M, Sugimoto J, Matsumoto K and Ishii T: The decrease in total collagen fibers in the liver by hepatocyte growth factor after formation of cirrhosis induced thioacetamide. Biochem Pharmacol 59: 681-690, 2000.
    • (2000) Biochem Pharmacol , vol.59 , pp. 681-690
    • Sato, M.1    Kakubari, M.2    Kawamura, M.3    Sugimoto, J.4    Matsumoto, K.5    Ishii, T.6
  • 25
    • 0037423786 scopus 로고    scopus 로고
    • A trial on regeneration therapy of rat liver cirrhosis by controlled release of hepatocyte growth factor
    • DOI 10.1016/S0168-3659(02)00463-7
    • Oe S, Fukunaka Y, Hirose T, Yamaoka Y and Tabata Y: A trial on regeneration therapy of rat liver cirrhosis by controlled release of hepatocyte growth factor. J Control Release 307: 146-151, 2003. (Pubitemid 36287337)
    • (2003) Journal of Controlled Release , vol.88 , Issue.2 , pp. 193-200
    • Oe, S.1    Fukunaka, Y.2    Hirose, T.3    Yamaoka, Y.4    Tabata, Y.5
  • 26
    • 10644257858 scopus 로고    scopus 로고
    • Pharmacokinetic study of recombinant human hepatocyte growth factor administered in a bolus intravenously or via portal vein
    • Ido A, Moriuchi A, Kim ID, et al: Pharmacokinetic study of recombinant human hepatocyte growth factor administered in a bolus intravenously or via portal vein. Hepatol Res 30: 175-181, 2004.
    • (2004) Hepatol Res , vol.30 , pp. 175-181
    • Ido, A.1    Moriuchi, A.2    Kim, I.D.3
  • 27
    • 0001276586 scopus 로고
    • Experimental pathology of the liver: Restoration of the liver of the white rat following partial surgical removal
    • Higgins GM and Anderson RM: Experimental pathology of the liver: restoration of the liver of the white rat following partial surgical removal. Arch Pathol 12: 186-202, 1931.
    • (1931) Arch Pathol , vol.12 , pp. 186-202
    • Higgins, G.M.1    Anderson, R.M.2
  • 29
    • 0026521507 scopus 로고
    • Phorbol ester-induced secretion of human hepatocyte growth factor by human skin fibroblasts and its inhibition by dexamethasone
    • Gohda E, Kataoka H, Tsubouchi H, Daikuhara Y and Yamamoto I: Phorbol ester-induced secretion of human hepatocyte growth factor by human skin fibroblasts and its inhibition by dexamethasone. FEBS Lett 301: 107-110, 1992.
    • (1992) FEBS Lett , vol.301 , pp. 107-110
    • Gohda, E.1    Kataoka, H.2    Tsubouchi, H.3    Daikuhara, Y.4    Yamamoto, I.5
  • 30
    • 0027506178 scopus 로고
    • Enhancement of human hepatocyte growth factor production by interleukin-1α ar-α by fibroblasts in culture
    • Tamura M, Arakaki N, Tsubouchi H, Takada H and Daikuhara Y: Enhancement of human hepatocyte growth factor production by interleukin-1α ar-α by fibroblasts in culture. J Biol Chem 268: 8140-8145, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 8140-8145
    • Tamura, M.1    Arakaki, N.2    Tsubouchi, H.3    Takada, H.4    Daikuhara, Y.5
  • 32
    • 0027289115 scopus 로고
    • Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII
    • Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y and Kitamura N: Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. J Biol Chem 268: 10024-10028, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 10024-10028
    • Miyazawa, K.1    Shimomura, T.2    Kitamura, A.3    Kondo, J.4    Morimoto, Y.5    Kitamura, N.6
  • 33
    • 0028305195 scopus 로고
    • Proteolytic activation of hepatocyte growth factor in response to tissue injury
    • Miyazawa K, Shimomura T, Naka D and Kitamura N: Proteolytic activation of hepatocyte growth factor in response to tissue injury. J Biol Chem 269: 8966-8970, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 8966-8970
    • Miyazawa, K.1    Shimomura, T.2    Naka, D.3    Kitamura, N.4
  • 34
    • 0030044647 scopus 로고    scopus 로고
    • Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator
    • Miyazawa K, Shimomura T and Kitamura N: Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. J Biol Chem 271: 3615-3618, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 3615-3618
    • Miyazawa, K.1    Shimomura, T.2    Kitamura, N.3
  • 35
    • 0028912994 scopus 로고
    • Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator
    • Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y and Kitamura N: Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. Eur J Biochem 229: 257-261, 1995.
    • (1995) Eur J Biochem , vol.229 , pp. 257-261
    • Shimomura, T.1    Miyazawa, K.2    Komiyama, Y.3    Hiraoka, H.4    Naka, D.5    Morimoto, Y.6    Kitamura, N.7
  • 36
    • 0030894268 scopus 로고    scopus 로고
    • Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor
    • Shimomura T, Denda K, Kitamura A, et al: Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J Biol Chem 272: 6370-6376, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 6370-6376
    • Shimomura, T.1    Denda, K.2    Kitamura, A.3
  • 37
    • 0034704164 scopus 로고    scopus 로고
    • Hepatocyte growth factor activator inhibitor type-1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment
    • Kataoka H, Shimomura T, Kawaguchi T, et al: Hepatocyte growth factor activator inhibitor type-1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. J Biol Chem 275: 40453-40462, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 40453-40462
    • Kataoka, H.1    Shimomura, T.2    Kawaguchi, T.3
  • 38
    • 29744452649 scopus 로고    scopus 로고
    • Administration of rhHGF-activator via portal vein stimulates the regeneration of cirrhotic liver after partial hepatectomy in rats
    • doi:10.1016/j.jss.2005.08.002
    • Yanagida H, Kaibori M, Hijikawa T, Kwon A-H, Kamiyama Y and Okumura T: Administration of rhHGF-activator via portal vein stimulates the regeneration of cirrhotic liver after partial hepatectomy in rats. J Surg Res doi:10.1016/j.jss.2005.08.002.
    • J Surg Res
    • Yanagida, H.1    Kaibori, M.2    Hijikawa, T.3    Kwon, A.-H.4    Kamiyama, Y.5    Okumura, T.6
  • 39
    • 0032578596 scopus 로고    scopus 로고
    • Activated stellate cells express c-met and respond to hepatocyte growth factor to enhance transforming growth factor β1 expression and DNA synthesis
    • Ikeda H, Nagoshi S, Ohno A, Yanase M, Maekawa H and Fujiwara K: Activated stellate cells express c-met and respond to hepatocyte growth factor to enhance transforming growth factor β1 expression and DNA synthesis. Biochem Biophys Res Commun 250: 769-775, 1998.
    • (1998) Biochem Biophys Res Commun , vol.250 , pp. 769-775
    • Ikeda, H.1    Nagoshi, S.2    Ohno, A.3    Yanase, M.4    Maekawa, H.5    Fujiwara, K.6
  • 41
    • 0033781716 scopus 로고    scopus 로고
    • Hepatic stellate cells: A target for the treatment of liver fibrosis
    • Wu J and Zern MA: Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol 35: 665-672, 2000.
    • (2000) J Gastroenterol , vol.35 , pp. 665-672
    • Wu, J.1    Zern, M.A.2
  • 42
    • 0030032905 scopus 로고    scopus 로고
    • Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rats
    • Tuchweber B, Desmouliere A, Bochaton-Piallat ML, Rubbia Brandt L and Gabiani G: Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rats. Lab Invest 74: 265-278, 1996.
    • (1996) Lab Invest , vol.74 , pp. 265-278
    • Tuchweber, B.1    Desmouliere, A.2    Bochaton-Piallat, M.L.3    Rubbia Brandt, L.4    Gabiani, G.5
  • 43
    • 0032742051 scopus 로고    scopus 로고
    • Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibronogenic potential
    • Knittel T, Kobold D, Saile B, Grundmann A, Neubauer K, Piscaglia F and Ramadori G: Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibronogenic potential. Gastroenterology 117: 1205-1221, 1999.
    • (1999) Gastroenterology , vol.117 , pp. 1205-1221
    • Knittel, T.1    Kobold, D.2    Saile, B.3    Grundmann, A.4    Neubauer, K.5    Piscaglia, F.6    Ramadori, G.7
  • 44
    • 0036172597 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cell line
    • Ozaki I, Zhao G, Mizuta T, et al: Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cell line. J Hepatol 36: 169-178, 2002.
    • (2002) J Hepatol , vol.36 , pp. 169-178
    • Ozaki, I.1    Zhao, G.2    Mizuta, T.3
  • 45
    • 17144366279 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis
    • Kim W-H, Matsumoto K, Bessho K and Nakamura T: Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 166: 1017-1028, 2005.
    • (2005) Am J Pathol , vol.166 , pp. 1017-1028
    • Kim, W.-H.1    Matsumoto, K.2    Bessho, K.3    Nakamura, T.4
  • 46
    • 0026448434 scopus 로고
    • Importance of the liver in plasma clearance of hepatocyte growth factor in rats
    • Liu KX, Kato Y, Narukawa M, et al: Importance of the liver in plasma clearance of hepatocyte growth factor in rats. Am J Physiol 263: G645-G649, 1992.
    • (1992) Am J Physiol , vol.263
    • Liu, K.X.1    Kato, Y.2    Narukawa, M.3
  • 47
    • 0032967785 scopus 로고    scopus 로고
    • Efficient extraction by the liver governs overall elimination of hepatocyte growth factor in rats
    • Kato M, Kato Y, Nakamura T and Sugiyama Y: Efficient extraction by the liver governs overall elimination of hepatocyte growth factor in rats. J Pharmacol Exp Ther 290: 373-379, 1999.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 373-379
    • Kato, M.1    Kato, Y.2    Nakamura, T.3    Sugiyama, Y.4
  • 48
    • 0029610193 scopus 로고
    • Contribution of parenchymal and non-parenchymal liver cells to the clearance of hepatocyte growth factor from the circulation in rats
    • Liu KX, Kato Y, Terasaki T, Aoki S, Okumura K, Nakamura T and Sugiyama Y: Contribution of parenchymal and non-parenchymal liver cells to the clearance of hepatocyte growth factor from the circulation in rats. Pharm Res 12: 1737-1740, 1995.
    • (1995) Pharm Res , vol.12 , pp. 1737-1740
    • Liu, K.X.1    Kato, Y.2    Terasaki, T.3    Aoki, S.4    Okumura, K.5    Nakamura, T.6    Sugiyama, Y.7
  • 49
    • 0031730475 scopus 로고    scopus 로고
    • Ligand-induced downregulation of receptor-mediated clearance of hepatocyte growth factor in rats
    • Liu KX, Kato Y, Kino I, Nakamura T and Sugiyama Y: Ligand-induced downregulation of receptor-mediated clearance of hepatocyte growth factor in rats. Am J Physiol 275: E835-E842, 1998.
    • (1998) Am J Physiol , vol.275
    • Liu, K.X.1    Kato, Y.2    Kino, I.3    Nakamura, T.4    Sugiyama, Y.5


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