First experience on the effect of in-feed lincomycin for the control of proliferative enteropathy in growing pigs

Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

Volumn 53, Issue 3, 2006, Pages 157-162

  Alexopoulos, C ^a   Tassis, P D ^b   Kyriakis, C S ^b   Tzika, E D ^b   Papatsiros, V ^b   Kyriakis, S C ^b  

^a Clinic of Obstetrics and Artificial Insemination   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; LINCOMYCIN;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; DESULFOVIBRIONACEAE INFECTION; DRUG EFFECT; FECES; FEMALE; GENETICS; ILEITIS; ISOLATION AND PURIFICATION; LAWSONIA; MALE; MICROBIOLOGY; NEWBORN; POLYMERASE CHAIN REACTION; RANDOMIZATION; SWINE; SWINE DISEASE; TREATMENT OUTCOME; WEIGHT GAIN;

ANIMAL FEED; ANIMALS; ANIMALS, NEWBORN; ANTI-BACTERIAL AGENTS; DESULFOVIBRIONACEAE INFECTIONS; FECES; FEMALE; ILEITIS; LAWSONIA BACTERIA; LINCOMYCIN; MALE; POLYMERASE CHAIN REACTION; RANDOM ALLOCATION; SWINE; SWINE DISEASES; TREATMENT OUTCOME; WEIGHT GAIN;

ANIMALIA; LAWSONIA INTRACELLULARIS; SUS SCROFA;

EID: 33644924903     PISSN: 0931184X     EISSN: 14390442     Source Type: Journal    
DOI: 10.1111/j.1439-0442.2006.00803.x     Document Type: Article

References (31)

1. Bane D. P. E. Neumann C. J. Gebhart I. A. Gardner B. Norby 2001 Porcine proliferative enteropathy: a case-control study in swine herds in the United States J. Sw. Health Prod. 9-4 155 158
2. Boom R. C. J. A. Sol M. M. M. Salimans C. L. Jansen P. M. E. Wertheim-Van Dillen J. Noorda-Van Der 1990 Rapid and simple method for purification of nucleic acids J. Clin. Microbiol. 28 495 503
3. Cooper D. M. D. L. Swanson C. J. Gebhart 1997 Diagnosis of proliferative enteritis in frozen and formalin-fixed, paraffin-embedded tissues from a hamster, horse, deer and ostrich using L. intracellularis-specific multiplex PCR assay Vet. Microbiol. 54 47 62
4. Federation of Veterinarians of Europe (FVE) 2001 Code of Good Veterinary Practice (GVP Code) pp 4 7 Available at: (accessed 28 February 2006)
5. Food and Drug Administration (FDA) 2002 Lincomycin Feed Medications for the Control of Porcine Proliferative Enteropathies (ileitis) Caused by Lawsonia intracellularis. Supplemental new animal drug application, NADA 97-505 pp 1 10 FDA Rockville, MD, USA
6. Gebhart C. J. 1995 Direct In Vitro Testing of Antimicrobial Agents for the Proliferative Enteropathy. Research Investment Report Department of Veterinary Pathology, University of Edinburgh Edinburgh, UK
7. Glock R. D. 1981 Lincomycin for treatment of swine dysentery In: Howard J. L. ed. Current Veterinary Therapy Food Animal Practice pp 736 736 WB Saunders Philadelphia, PA, USA
8. Gogolewski R. P. R. W. Cook E. S. Batterham 1991 Suboptimal growth associated with porcine intestinal adenomatosis in pigs in nutritional studies Aust. Vet. J. 68 406 408
9. Jones G. F. G. E. Ward C. J. Gebhart M. P. Murtaugh G. Lin 1993 Enhanced detection of intracellular organism of swine proliferative enteritis, ileal symbiont intracellularis, in faeces by polymerase chain reaction J. Clin. Microbiol. 31 2611 2615
10. Knittel J. P. D. M. Jordan K. J. Schwartz B. H. Janke M. B. Roof S. McOrist D. L. Harris 1998 Evaluation of antemortem polymerase chain reaction and serologic methods for detection of L. intracellularis-exposed pigs Am. J. Vet. Res. 59 722 726
11. Knittel J. P. J. Kroll M. Mathes F. Sick M. B. Roof S. McOrist 2000 Efficacy of an avirulent Lawsonia intracellularis vaccine in swine In: Cargill C. McOrist S. eds Proceedings of the 16th International Pig Veterinary Society Congress, Melbourne, Australia p 24 Causal Productions Pty Ltd Rundle Mall, SA, Australia
12. Kyriakis S. C. A. Tsinas S. Lekkas K. Sarris E. Bourtzi-Hatzopoulou 1996 Clinical evaluation of in-feed zinc bacitracin for the control of porcine intestinal adenomatosis in growing/fattening pigs Vet. Rec. 138 489 492
13. McOrist S. C. J. Gebhart 1999 Porcine proliferative enteropathies In: Straw B. E. D'Allaire S. Mengeling W. L. Taylor D. J. eds Diseases of Swine 8th edn pp 521 534 Blackwell Sciences London, UK
14. McOrist S. C. J. Gebhart G. H. K. Lawson 1994 Polymerase chain reaction for the diagnosis of proliferative enteropathy Vet. Microbiol. 41 201 212
15. McOrist S. C. J. Gebhart R. Boid S. M. Barns 1995 Characterization of Lawsonia intracellularis gen. nov. sp. nov., the obligatory intracellular bacterium of porcine proliferative enteropathy Int. J. Syst. Bacteriol. 33 1136 1142
16. McOrist S. S. H. Smith M. F. Shearn M. M. Carr D. J. S. Miller 1996 Treatment and prevention of porcine proliferative enteropathy with oral tiamulin Vet. Rec. 139 615 618
17. McOrist S. S. H. Smith L. E. Green 1997a Estimate of direct financial losses due to porcine proliferative enteropathy Vet. Rec. 140 579 581
18. McOrist S. J. Morgan M. F. Veenhuizen K. Lawrence H. W. Kroger 1997b Oral administration of tylosin phosphate for the treatment and prevention of proliferative enteropathy in pigs Am. J. Vet. Res. 58 136 139
19. McOrist S. A. Muller-Wager D. Kratzer C.-G. Sjsten 2000 Therapeutic efficacy of water-soluble lincomycin-spectinomycin powder against porcine proliferative enteropathy in a European field study Vet. Rec. 146 61 65
20. Merck 1998 Merck Veterinary Manual 8th edn pp 1782 1784 Merck & Co. Inc. Whitehouse Station, NJ, USA
21. Organization for Economic Co-operation and Development (OECD) 1998 Series on Principles of Good Laboratory Practice (GLP) and Compliance Monitoring pp 2 41 Organization for Economic Co-operation and Development Paris, France
22. Papich M. G. J. E. Riviere 2001 Lincomycin In: Adams H. R. ed. Veterinary Pharmacology and Therapeutics 8th edn, pp 882 884 Iowa University Press Ames, IA, USA
23. Quinn P. J. M. E. Carter B. K. Marrey G. R. Carter 1994 Reagents and stains In: Quinn P. J. Carter M. E. Marrey B. K. Carter G. R. eds Clinical Veterinary Microbiology, Appendix 1 pp 615 619 Wolfe Publications London, UK
24. Rowland A. C. G. H. K. Lawson 1992 Porcine proliferative enteropathies In: Leman A. D. Straw B. E. Mengeling W. L. D'Allaire S. Taylor D. J. eds Diseases of Swine 8th edn, pp 521 534 Wolfe Publications London, UK
25. Taylor D. J. 1995 Proliferative enteropathy In: Taylor D. J. ed. Pig Diseases 6th edn, pp 154 158 Burlington Press Cambridge, UK
26. The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines and Inspections, EMEA CVMP 816/00 2001 Guidelines on Statistical Principles for Veterinary Clinical Trials pp 6 7 EMEA CVMP London, UK
27. The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, EMEA CVMP 595 1998 VICH Topic GL9 (GCP) Step 4 Guideline on Good Clinical Practices pp 1 28 EMEA CVMP London, UK
28. Tsinas A. S. C. Kyriakis S. Lekkas K. Sarris E. Bourtzi-Hatzopoulou K. Saoulidis 1998 Control of proliferative enteropathy in growing/fattening pigs using growth promoters J. Vet. Med. B 45 115 127
29. Veenhuizen M. F. T. E. Elam N. Soenksen 1998 The potential economic impact of porcine proliferative enteropathy on the U.S. swine industry In: Done S. Thomson J. Varley M. eds Proceedings of the 15th International Pig Veterinary Society Congress, Birmingham, UK vol. 2 p 64 Nottingham University Press Nottingham
30. Winkelman N. L. J. P. Crane G. D. Elfring D. Dal Kratzer D. M. Meeuwse K. J. Dame S. L. Buckham C. J. Gebhart 2002 Lincomycin-medicated feed for the control of porcine proliferative enteropathy (ileitis) in swine J. Sw. Health Prod. 10 107 111
31. Young B. J. 1969 A reliable method for the demonstration of spirochetes in tissue sections J. Med. Lab. Technol. 26 248 252