Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 1, 2006, Pages

  Pei, Hong ^a   Gu, Jiali ^a   Thimmalapura, Pushpa Rekha ^a   Mison, Angeles ^a   Nadler, Jerry L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Lisofylline; Zucker rat

Indexed keywords

ANTIINFLAMMATORY AGENT; ARACHIDONATE 12 LIPOXYGENASE; LISOFYLLINE; STAT4 PROTEIN; DRUG DERIVATIVE; ECTODYSPLASIN A; INSULIN; KI 67 ANTIGEN; LIPID; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL WALL; BODY WEIGHT; CAROTID ARTERY INJURY; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; HISTOPATHOLOGY; INFLAMMATION; INSULIN RESISTANCE; INTIMA; MACROPHAGE; METABOLIC SYNDROME X; MONOCYTE; NONHUMAN; OBESITY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BLOOD; CAROTID ARTERY; DISEASE MODEL; ENZYMOLOGY; GENE EXPRESSION; GENETICS; GLUCOSE BLOOD LEVEL; INJURY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; ZUCKER RAT;

ANGIOPLASTY, BALLOON; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 12-LIPOXYGENASE; BLOOD GLUCOSE; BODY WEIGHT; CAROTID ARTERIES; CAROTID ARTERY INJURIES; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ECTODYSPLASINS; FEMALE; GENE EXPRESSION; INFLAMMATION; INSULIN; KI-67 ANTIGEN; LIPIDS; MEMBRANE PROTEINS; METABOLIC SYNDROME X; PENTOXIFYLLINE; PHOSPHORYLATION; RATS; RATS, ZUCKER; STAT4 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTORS; TUNICA INTIMA;

EID: 33644875634     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00133.2005     Document Type: Article

References (43)

1. Bleich D, Chen S, Gu J, Thomas L, Scott S, Gonzales N, Natarajan R, and Nadler JL. Interleukin-1β regulates the expression of a leukocyte type of 12-lipoxygenase in rat islets, and RIN m5F cells. Endocrinology 136: 5736-5744, 1995.
2. Bright JJ, Du C, Coon M, Sriram S, and Klaus SJ. Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: an effect of the novel anti-inflammatory drug Lisofylline. J Immunol 161: 7015-7022, 1998.
3. Coon ME, Diegel M, Leshinsky N, and Klaus SJ. Selective pharmacologic inhibition of murine and human IL-12-dependent Th1 differentiation and IL-12 signaling. J Immunol 163: 6567-6574, 1999.
4. Elezi S, Kastrati A, Pache J, Wehinger A, Hadamitzky M, Dirschinger J, Neumann FJ, and Schomig A. Diabetes mellitus and clinical and angiographic outcome after coronary stent placement. J Am Coll Cardiol 32: 1866-1873 1998.
5. Furukawa Y, Matsumori A, Ohashi N, Shioi T, Ono K, Harada A, Matsushima K, and Sasayama S. Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries. Circ Res 84: 306-314, 1999.
6. George CLS, Fantuzzi G, Bursten S, Leer L, and Abraham E. Effects of lisofylline on hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol 276: L776-L785, 1999.
7. Gu J, Pei H, Thomas L, Nadler JL, Rossi JJ, Lanting L, and Natarajan R. Ribozyme-mediated inhibition of rat leukocyte-type 12-lipoxygenase prevents intimal hyperplasia in balloon-injured rat carotid arteries. Circulation 103: 1446-1452, 2001.
8. Gu J, Wen Y, Mison A, and Nadler JL. 12-Lipoxygenase pathway increases aldosterone production, 3′,5′-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protin kinase activation in H295R human adrenocortical cells. Endocrinology 144: 534-543, 2003.
9. Hayashi S, Watanabe N, Nakazawa K, Suzuki J, Tsushima K, Tamatani T, Sakamoto S, and Isobe M. Roles of P-selectin in inflammation, neointimal formation, and vascular remodeling in balloon-injured rat carotid arteries. Circulation 102: 1710-1717, 2000.
10. Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Pratico D, Witztum JL, Nadler JL, Funk CD, and Ley K. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation 110: 2024-2031, 2004.
11. Kaplan MH, Sun YL, Hoey T, and Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in STAT4-deficient mice. Nature 382: 174-177, 1996.
12. Kasiske BL, O'Donnell MP, and Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 19: 111-115, 1992.
13. Kornowski R, Mintz GS, Kent KM, Pichard AD, Satler LF, Bucher TA, Hong MK, Popma JJ, and Leon MB. Increased restenosis in diabetes mellitus after interventions is due to exaggerated intimal hyperplasia. A serial intravascular ultrasound study. Circulation 95: 1366-1369, 1997.
14. Lentsch AB, Kato A, Davis B, Wang W, Chao C, and Edwards MJ. STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia. J Clin Invest 108: 1475-1482, 2001.
15. Libby P, Schwartz D, Brogi E, Tanaka H, and Clinton SK. A cascade model for restenosis. A special case of atherosclerosis progression. Circulation 86: III47-III52, 1992.
16. Mori E, Komori K, Yamaoka T, Tanii M, Kataoka C, Takeshita A, Usui M, Egashira K, and Sugimachi K. Essential role of monocyte chemoattractant protein-1 in development of restenotic changes (neointimal hyperplasia and constrictive remodeling) after balloon angioplasty in hypercholesterolemic rabbits. Circulation 105: 2905-2910, 2002.
17. Natarajan R, Bai W, Gu JL, Rangarajan V, and Nadler J. Platelet-derived growth factor BB mediated regulation of 12-lipoxygenase in porcine aortic smooth muscle cells. J Cell Physiol 169: 391-400, 1996.
18. Natarajan R and Nadler JL. Lipid inflammatory mediators in diabetic vascular disease. Arterioscler Thromb Vasc Biol 24: 1-8, 2004.
19. Natarajan R, Pei H, Gu J, Sarma JM, and Nadler J. Evidence for 12-lipoxygenase induction in the vessel wall following balloon injury. Cardiovasc Res 41: 489-499, 1999.
20. Natarajan R, Stern N, and Nadler JL. The role of arachidonic acid metabolites on rennin and vascular smooth muscle cell growth. In: Contemporary Endorinology: Endocrinology of the Vasculature, edited by Sowers JR. Totowa, NJ: Humana, p. 373-387.
21. Nishimoto Y, Miyazaki Y, Toki Y, Murakami R, Shinoda M, Fukushima A, and Kanayama H. Enhanced secretion of insulin plays a role in the development of atherosclerosis and restenosis of coronary arteries: elective percutaneous transluminal coronary angioplasty in patients with effort angina. J Am Coll Cardiol 32: 1624-1629, 1998.
22. Oguchi S, Dimayuga P, Zhu J, Chyu K, Yano J, Shah PK, Nilsson J, and Cercek B. Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 20: 1729-1736, 2000.
23. Osanai H, Kanayama H, Miyazaki Y, Fukushima A, Shinoda M, and Ito T. Usefulness of enhanced insulin secretion during an oral glucose tolerance test as a predictor of restenosis after direct percutaneous transluminal coronary angioplasty during acute myocardial infarction in patients without diabetes mellitus. Am J Cardiol 81: 698-701, 1998.
24. Park SH, Marso SP, Zhou Z, Foroudi F, Topol EJ, and Lincoff AM. Neointimal hyperplasia after arterial injury is increased in a rat model of noninsulin-dependent diabetes mellitus. Circulation 104: 815- 819, 2001.
25. Patricia MK, Kim JA, Harper CM, Shih PT, Berliner JA, Natarajan R, Nadler JL, and Hedrick CC. Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells. Arterioscler Thromb Vasc Biol 19: 2615-2622, 1999.
26. Phillips JW, Barringhaus KG, Sanders JM, Hesselbacher SE, Czarnik AC, Manka D, Vestweber D, Ley K, and Sarembock IJ. Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice. Circulation 107: 2244-2249, 2003.
27. Raman K, Kaplan MH, Hogaboam CM, Berlin A, and Lukacs NW. STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airways inflammation locally via alteration of chemokines. J Immunol 170: 3859-3865, 2003.
28. Reilly KB, Srinivasan S, Hatley ME, Patricia MK, Lannigan J, Bolick DT, Vandenhoff G, Pei H, Natarajan R, Nadler JL, and Hedrick CC. 12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo. J Biol Chem 279: 9440-9450, 2004.
29. Ribau JC, Hadcock SJ, Teoh K, DeReske M, and Richardson M. Endothelial adhesion molecule expression is enhanced in the aorta and internal mammary artery of diabetic patients. J Surg Res 85: 225-233, 1999.
30. Rice GC, Rosen J, Weeks R, Michnick J, Bursten S, Bianco JA, and Singer JW. CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo. Shock 1: 254-266, 1994.
31. Ridray S, Heudes D, Michel O, Penicaud L, and Ktorza A. Increased SMC proliferation after endothelial injury in hyperinsulinemic obese Zucker rats. Am J Physiol Heart Circ Physiol 267: H1976-H1983, 1994.
32. Shelton J, Wang D, Gupta H, Wyss JM, Oparil S, and White CR. The neointimal response to endovascular injury is increased in obese Zucker Rats. Diabetes Obes Metab 6: 415-423, 2003.
33. Simon DI, Dhen Z, Seifert P, Edelman ER, Ballantyne CM, and Rogers C. Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty. J Clin Invest 105: 293-300, 2000.
34. Stein B, Weintraub WS, Gebhart SP, Cohen-Bernstein CL, Grosswald R, Liberman HA, Douglas JS Jr, Morris DC, and King SB III. Influence of diabetes mellitus on early and late outcome after percutaneous transluminal coronary angioplasty. Circulation 91: 979-989, 1995.
35. Stenina OI, Krukovets I, Wang K, Zhou Z, Forudi F, Penn MS, Topol EJ, and Plow EF. Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat. Circulation 107: 3209-3215, 2003.
36. Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, and Ihle JN. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382: 171-174, 1996.
37. Torpey N, Maher SE, Bothwell AL, and Pober JS. Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells. J Biol Chem 279: 26789-26796, 2004.
38. Van Belle E, Bauters C, Hubert E, Bodart JC, Abolmaali K, Meurice T, McFadden EP, Lablanche JM, and Bertrand ME. Restenosis rates in diabetic patients: a comparison of coronary stenting and balloon angioplasty in native coronary arteries. Circulation 96: 1454 -1460, 1997.
39. Yang Z, Chen M, and Nadler JL. Lisofylline: a potential lead for the treatment of diabetes. Biochem Pharmacol 69: 1-5, 2005.
40. Yoshimoto T, Suzuki H, Yamamoto S, Takai T, Yokoyama C, and Tanabe T. Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes. Proc Natl Acad Sci USA 87: 2142-2146, 1990.
41. Zhou Z, Penn MS, Forudi F, Zhou X, Tarakji K, Topol EJ, Lincoff AM, and Wang K. Administration of recombinant P-selectin glycoprotein ligand Fc fusion protein suppresses inflammation and neointimal formation in Zucker diabetic rat model. Arterioscler Thromb Vasc Biol 22: 1598-1603, 2002.
42. Zhou Z, Wang K, Penn MS, Marso SP, Lauer MA, Forudi F, Zhou X, Qu W, Lu Y, Stern DM, Schmidt AM, Lincoff AM, and Topol EJ. Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury. Circulation 107: 2238-2243, 2003.
43. Zucker LM and Antoniades HN. Insulin and obesity in the Zucker genetically obese rat "fatty". Endocrinology 90: 1320-1330, 1972.