Prolonged stability of stored vancomycin, gentamicin, and heparin for use in the antibiotic-lock technique

ASAIO Journal

Volumn 51, Issue 6, 2005, Pages 761-763

  Bastani, Bahar ^a   Amin, Kamal ^a   Herr, Aaron ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOASSAY; BIOMEDICAL ENGINEERING; DIALYSIS; PATIENT TREATMENT;

ANTICOAGULANT; HEMODIALYSIS; HEPARIN; VANCOMYCIN;

CATHETERS;

GENTAMICIN; HEPARIN; VANCOMYCIN; ANTICOAGULANT AGENT; ANTIINFECTIVE AGENT;

ANTIBIOTIC LOCK; ANTICOAGULATION; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG DELIVERY SYSTEM; DRUG SOLUTION; DRUG STABILITY; DRUG STORAGE; FREEZING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PSEUDOMONAS AERUGINOSA; BACTEREMIA; DRUG EFFECT; HUMAN; IN VITRO STUDY; INDWELLING CATHETER; RENAL REPLACEMENT THERAPY; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTICOAGULANTS; BACTEREMIA; CATHETERS, INDWELLING; DRUG STABILITY; GENTAMICINS; HEPARIN; HUMANS; PSEUDOMONAS AERUGINOSA; RENAL DIALYSIS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN;

EID: 33644873487     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mat.0000183656.75618.09     Document Type: Article

References (21)

1. Schwab SJ, Beathard GA: The hemodialysis catheter conundrum: Hate living with them, but can't live without them. Kidney Int 56: 1-17, 1999.
2. Tokars JI, Miller ER, Alter MJ, Ardunio MJ: National surveillance of dialysis-associated diseases in the United States, 1997. Semin Dial 13: 75-85, 2000.
3. Kovalik EC, Raymond JR, Albers FJ, et al: A clustering of epidural abscesses in chronic hemodialysis patients: Risk of salvaging access catheters in cases of infection. J Am Soc Nephrol 7: 2264-2267, 1996.
4. Marr KA, Sexton DJ, Conlon PJ, et al: Catheter-related bacteremia and outcome of attempted salvage in patients undergoing hemodialysis. Ann Intern Med 127: 275-280, 1997.
5. Moss AH, Vasilakis C, Holley JL, et al: Use of a silicone dual-lumen catheter with Dacron cuff as a long-term vascular access for hemodialysis patients. Am J Kidney Dis 16: 211-215, 1990.
6. Swartz RD, Messana JM, Boyer CJ, et al: Successful use of cuffed central venous hemodialysis catheters inserted percutaneously. J Am Soc Nephrol 4: 1719-1725, 1994.
7. Saad TF: Bacteremia associated with tunneled, cuffed hemodialysis catheters. Am J Kidney Dis 34: 1114-1124, 1999.
8. NKF-DOQI Clinical Practice Guidelines for Vascular Access: Guideline 26: Treatment of infection of tunneled dialysis catheters. Am J Kidney Dis 37: S166, 2001.
9. Capdevila JA, Separra A Planes AM et al: Successful treatment of hemodialysis catheter-related sepsis without catheter removal. Nephrol Dial Transplant 8: 231-234, 1993.
10. Boorgu R, Dubrow AJ, Levin NW, et al: Adjunctive antibiotic/anticoagulant lock therapy in the treatment of bacteremia associated with the use of a subcutaneously implanted hemodialysis access device. ASAIO J 46: 767-770, 2000.
11. Krishnasami Z, Carlton D, Bimbo L, et al: Management of hemodialysis catheter-related bacteremia with an adjunctive antibiotic lock solution. Kidney Int 61: 1136-1142, 2002.
12. Passerini L, Lam K, Costerton JW, King EG: Biofilms on indwelling vascular catheters. Crit Care Med 20: 665-673, 1992.
13. Costerton JW, Stewart PS, Greenberg EP: Bacterial biofilms: A common cause of persistent infections. Science 284: 1318-1322, 1999.
14. Andris DA, Krzywda EA, Edmiston CE, et al: Elimination of intraluminal colonization by antibiotic lock in silicone vascular catheters. Nutrition 14: 427-432, 1998.
15. Mermel LA, Farr BM, Sherertz RJ, et al: Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis 32: 1249-1272, 2001.
16. Bastani B, Minton J, Islam S: Insufficient penetration of systemic vancomycin into the PermCath lumen. Nephrol Dial Transplant 15: 1035-1037, 2000.
17. Anthony TU, Rubin LG: Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (ports). Antimicrob Ag Chemother 43: 2074-2076, 1999.
18. Riley BB : Incompatibilities in intravenous solution. J Hosp Pharm 28: 228, 1970.
19. Regamey C, Schaberg D, Kirby WM: Inhibitory effect of heparin on Gentamicin concentrations in blood. Antimicrob Ag Chemother 1: 329-332, 1972.
20. McIntyre CW, Hulme LJ, Taal M, Fluck RJ: Locking of tunneled hemodialysis catheters with gentamicin and heparin. Kidney Int 66: 801-805, 2004.
21. Vercaigne LM, Sitar DS, Penner B, et al: Antibiotic-heparin lock: In vitro antibiotics stability combined with heparin in a central venous catheter. Pharmacotherapy 20: 394-399, 2000.