3′-Untranslated region of the type 2 bradykinin receptor is a potent regulator of gene expression

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 2, 2006, Pages

  Zamorano, Rocio ^a   Suchindran, Sunil ^a   Gainer, James V ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Gene regulation; Polymorphism; Variable number of tandem repeats

Indexed keywords

BRADYKININ B2 RECEPTOR; LUCIFERASE; MESSENGER RNA; DACTINOMYCIN; NUCLEIC ACID SYNTHESIS INHIBITOR;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; PRIORITY JOURNAL; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VARIABLE NUMBER OF TANDEM REPEAT; BIOSYNTHESIS; CELL LINE; GENETIC TRANSFECTION; GENETICS; MOLECULAR GENETICS; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POLYADENYLATION; SEQUENCE HOMOLOGY;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; CELL LINE; DACTINOMYCIN; GENE EXPRESSION REGULATION; HUMANS; MINISATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEIC ACID SYNTHESIS INHIBITORS; POLYADENYLATION; RECEPTOR, BRADYKININ B2; RNA, MESSENGER; SEQUENCE HOMOLOGY; TRANSFECTION;

EID: 33644872594     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00009.2005     Document Type: Article

References (41)

1. Alfie ME, Sigmon DH, Pomposiello SI, and Carretero OA. Effect of high salt intake in mutant mice lacking bradykinin-B2 receptors. Hypertension 29: 483-487, 1997.
2. Baptista HA, Avellar MCW, Araujo RC, Pesquero JL, Schanstra JP, Bascands JL, Esteve JP, Paiva ACM, Bader M, and Pesquero JB. Transcriptional regulation of the rat bradykinin B2 receptor gene: identification of a silencer element. Mol Pharmacol 62: 1344-1355, 2002.
3. Bevilacqua A, Ceriani MC, Capaccioli S, and Nicolin A. Posttranscriptional regulation of gene expression by degradation of messenger RNAs. J Cell Physiol 195: 356-372, 2003.
4. Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, and Dikic I. Determination of bradykinin B-2 receptor in vivo phosphorylation sites and their role in receptor function. J Biol Chem 276: 40431-40440, 2001.
5. Braun A, Kammerer S, Maier E, Bohme E, and Roscher AA. Polymorphisms in the gene for the human B-2-bradykinin receptor. New tools in assessing a genetic risk for bradykinin-associated diseases. Immunopharmacology 33: 32-35, 1996.
6. Brown NJ, Gainer JV, Murphey LJ, and Vaughan DE. Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B-2 receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway. Circulation 102: 2190-2196, 2000.
7. Calixto JB, Cabrini DA, Ferreira J, and Campos MM. Kinins in pain and inflammation. Pain 87: 1-5, 2000.
8. Carrion AM, Mellstrom B, and Naranjo JR. Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element. Mol Cell Biol 18: 6921-6929, 1998.
9. 2 production in rat mesangial cells. Am J Physiol Renal Physiol 274: F532-F540, 1998.
10. Colman RW, Stadnicki A, Li F, Sartor RB, and Whalley EA. Specific blockade of bradykinin receptor-2 does not prevent development of gut inflammation, but attenuates accompanying arthritis in Lewis rats. Gastroenterology 116: A687, 1999.
11. Dixon BS. Cyclic-AMP selectively enhances bradykinin receptor synthesis and expression in cultured arterial smooth muscle-inhibition of angiotensin-ii and vasopressin response. J Clin Invest 93: 2535-2544, 1994.
12. Dray A. Kinins and their receptors in hyperalgesia. Can J Physiol Pharmacol 75: 704-712, 1997.
13. El Dahr SS, Harrison-Bernard LM, Dipp S, Yosipiv IV, and Meleg-Smith S. Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions in kidney development. Physiol Genomics 3: 121-131, 2000.
14. Fan H, Harrell JR, Dipp S, Saifudeen Z, and El Dahr SS. A novel pathological role of p53 in kidney development revealed by gene-environment interactions. Am J Physiol Renal Physiol 288: F98-F107, 2005.
15. Gainer JV, Morrow JD, Loveland A, King DJ, and Brown NJ. Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects. N Engl J Med 339: 1285-1292, 1998.
16. Haddad EB, Fox AJ, Rousell J, Burgess G, McIntyre P, Barnes PJ, and Chung KF. Posttranscriptional regulation of bradykinin b1 and b2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-α: modulation by dexamethasone. Mol Pharmacol 57: 1123-1131, 2000.
17. Hall JM. Bradykinin receptors. Gen Pharmacol 28: 1-6, 1997.
18. Hasan AA, Warnock M, Nieman M, Srikanth S, Mahdi F, Krishnan R, Tulinsky A, and Schmaier AH. Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin. Am J Physiol Heart Circ Physiol 285: H183-H193, 2003.
19. Kaplan AP, Joseph K, and Silverberg M. Pathways for bradykinin formation and inflammatory disease. J Allergy Clin Immunol 109: 195-209, 2002.
20. Kintsurashvili E, Duka I, Gavras I, Johns C, Farmakiotis D, and Gavras H. Effects of ANG II on bradykinin receptor gene expression in cardiomyocytes and vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 281: H1778-H1783, 2001.
21. Kuersten S and Goodwin EB. The power of the 3′-UTR: translational control and development. Nature Reviews Genetics 4: 626-637, 2003.
22. Ledo F, Link WA, Carrion AM, Echeverria V, Mellstrom B, and Naranjo JR. The DREAM-DRE interaction: key nucleotides and dominant negative mutants. Biochim Biophys Acta 1498: 162-168, 2000.
23. Lung CC, Chan EKL, and Zuraw BL. Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency. J Allergy Clin Immunol 99: 134-146, 1997.
24. Lung CC, Jagels MA, Daffem PJ, Tan EM, and Zuraw BL. Induction of human B2 bradykinin receptor mRNA and membrane receptors by IFN gamma. Immunopharmacology 39: 243-253, 1998.
25. Madeddu P, Emanueli C, Gaspa L, Salis B, Milia AF, Chao L, and Chao J. Role of the bradykinin B2 receptor in the maturation of blood pressure phenotype: lesson from transgenic and knockout mice. Immunopharmacology 44: 9-13, 1999.
26. Margolius HS. Kallikreins and kinins-some unanswered questions about system characteristics and roles in human-disease. Hypertension 26: 221-229, 1995.
27. Marks J, Saifudeen Z, Dipp S, and El Dahr SS. Two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter. J Biol Chem 278: 34158-34166, 2003.
28. Ostarecklederer A, Ostareck DH, Standart N, and Thiele BJ. Translation of 15-lipoxygenase messenger-RNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region. EMBO J 13: 1476-1481, 1994.
29. Pesquero JB, Lindsey CJ, Paiva ACM, Ganten D, and Bader M. Transcriptional regulatory elements in the rat bradykinin B-2 receptor gene. Immunopharmacology 33: 36-41, 1996.
30. Prado GN, Taylor L, Zhou X, Ricupero D, Mierke DF, and Polgar P. Mechanisms regulating the expression, self-maintenance, and signaling-function of the bradykinin B2 and B1 receptors. J Cell Physiol 193: 275-286, 2002.
31. Proud D. The kinin system in rhinitis and asthma. Clin Rev Allergy Immunol 16: 351-364, 1998.
32. Sachs AB and Varani G. Eukaryotic translation initiation: there are (at least) two sides to every story. Nat Struct Biol 7: 356-361, 2000.
33. Saifudeen Z, Dipp S, Fan H, and El Dahr SS. Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Am J Physiol Renal Physiol 288: F899-F909, 2005.
34. Sanz C, Mellstrom B, Link WA, Naranjo JR, and Fernandez-Luna JL. Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells. EMBO J 20: 2286-2292, 2001.
35. Schmaier AH. The plasma kallikrein-kinin system counterbalances the renin-angiotensin system. J Clin Invest 109: 1007-1009, 2002.
36. Schmidlin F, Scherrer D, Daeffler L, Bertrand C, Landry Y, and Gies JP. Interleukin-1β induces bradykinin B-2 receptor gene expression through a prostanoid cyclic AMP-dependent pathway in human bronchial smooth muscle cells. Mol Pharmacol 53: 1009-1015, 1998.
37. Shaw G and Kamen R. A conserved AU sequence from the 3′ untranslated region of Gm-Csf messenger-RNA mediates selective messenger-RNA degradation. Cell 46: 659-667, 1986.
38. Tebo J, Der S, Frevel M, Khabar KSA, Williams BRG, and Hamilton TA. Heterogeneity in control of mRNA stability by AU-rich elements. J Biol Chem 278: 12085-12093, 2003.
39. Wickens M, Anderson P, and Jackson RJ. Life and death in the cytoplasm: messages from the 3′ end. Curr Opin Genet Dev 7: 220-232, 1997.
40. Wilkie GS, Dickson KS, and Gray NK. Regulation of mRNA translation by 5′- and 3′-UTR-binding factors. Trends Biochem Sci 28: 182-188, 2003.
41. Zhou X, Prado GN, Chai M, Yang X, Taylor L, and Polgar P. Cloning and functional characterization of the 3′-untranslated region of the bradykinin B1 receptor mRNA. Posttranscriptional mRNA destabilization. FASEB J 13: A1409, 1999.