Development and validation of a liquid chromatography-ultraviolet absorbance detection assay using derivatisation for the novel marine anticancer agent ES-285·HCl [(2S,3R)-2-amino-3-octadecanol hydrochloride] and its pharmaceutical dosage form

Journal of Chromatography A

Volumn 1020, Issue 2, 2003, Pages 251-258

  Den Brok, Monique W J ^a   Nuijen, Bastiaan ^a   Miranda, Elena ^b   Floriano, Pablo ^b   Munt, Simon ^b   Manzanares, Ignacio ^b   Beijnen, Jos H ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b PHARMAMAR S A   (Spain)

Author keywords

(2S,3R) 2 amino 3 octadecanol hydrochloride; Derivatisation; Design of experiments; ES 285 HCl; LC; Phenylisothiocyanate

Indexed keywords

CELLS; STRESS ANALYSIS; TOXICITY; TUMORS; ULTRAVIOLET DETECTORS; ULTRAVIOLET RADIATION;

ANTICANCER AGENTS; CYTOTOXIC ACTIVITIES;

LIQUID CHROMATOGRAPHY;

2 AMINO 3 OCTADECANOL; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; ANTINEOPLASTIC AGENT; ES 285; PHENYL ISOTHIOCYANATE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; DERIVATIZATION; DRUG DEGRADATION; DRUG DETERMINATION; DRUG DOSAGE FORM; DRUG PURITY; DRUG STABILITY; LIGHT ABSORPTION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; VALIDATION PROCESS;

EID: 0347364867     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2003.08.094     Document Type: Article

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