Immunosuppressive activity of the immunophilin-binding drug sanglifehrin A in human whole blood: Potent inhibition of interleukin-6 produced by lymphocytes and monocytes

Scandinavian Journal of Immunology

Volumn 63, Issue 1, 2006, Pages 26-34

  Hartel C ^a   Iblher, P ^a   Puzik, A ^a   Wortmeier, K ^a   Ebel, B ^a   Schultz, C ^a   Muller Steinhardt M ^b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD3 ANTIBODY; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCLONAL ANTIBODY CD28; SANGLIFEHRIN A; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; LACTONE; MONOKINE; SPIRO COMPOUND;

ADULT; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; DRUG PROTEIN BINDING; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INTRACELLULAR SPACE; LYMPHOCYTE PROLIFERATION; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOLOGY; KINETICS; METABOLISM;

CYTOKINES; HUMANS; IMMUNOPHILINS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; INTERLEUKIN-6; KINETICS; LACTONES; LIPOPOLYSACCHARIDES; MONOCYTES; MONOKINES; RNA, MESSENGER; SPIRO COMPOUNDS; T-LYMPHOCYTES;

EID: 33644848955     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2006.01702.x     Document Type: Article

References (31)

1. Ho S Clipstone N Timmermann L et al. The mechanism of action of cyclosporin A and FK506 Clin Immunol Immunopathol 1996 80 S40 S45
2. McKeon F When worlds collide: immunosuppressants meet protein phosphatases Cell 1991 66 823 6
3. Sabers CJ Martin MM Brunn GJ et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells J Biol Chem 1995 270 815 22
4. Woltman AM Schlagwein N van der Kooij SW van Kooten C The novel cyclophilin-binding drug sanglifehrin A specifically affects antigen uptake receptor expression and endocytic capacity of human dendritic cells J Immunol 2004 172 6482 9
5. Thomson AW The effects of cyclosporin A on non-T cell components of the immune system J Autoimmun 1992 5 Suppl. A 167 76
6. Andersson J Nagy S Groth CG Andersson U Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level Immunology 1992 75 136 42
7. Matsue H Yang C Matsue K Edelbaum D Mummert M Takashima A Contrasting impacts of immunosuppressive agents (rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during antigen presentation J Immunol 2002 169 3555 64
8. Oliveira JG Xavier P Sampaio SM et al. Compared to mycophenolate mofetil, rapamycin induces significant changes on growth factors and growth factor receptors in the early days post-kidney transplantation Transplantation 2002 73 915 20
9. Sakuma S Kato Y Nishigaki F et al. FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells Br J Pharmacol 2000 130 1655 63
10. Weimer R Melk A Daniel V Friemann S Padberg W Opelz G Switch from cyclosporine A to tacrolimus in renal transplant recipients. impact on Th1, Th2, and monokine responses Hum Immunol 2000 61 884 97
11. Woltman AM de Fijter JW Kamerling SW et al. Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages Blood 2001 98 174 80
12. Waldmann H Transplantation tolerance-where do we stand? Nat Med 1999 5 1245 8
13. Fehr T Kallen J Oberer L Sanglier JJ Schilling W Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical properties J Antibiot (Tokyo) 1999 52 474 9
14. Sedrani R Kallen J Martin Cabrejas LM et al. Sanglifehrin-cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data J Am Chem Soc 2003 125 3849 59
15. Zhang LH Liu JO Sanglifehrin A A novel cyclophilin-binding immunosuppressant, inhibits IL-2-dependent T cell proliferation at the G1 phase of the cell cycle J Immunol 2001 166 5611 8
16. Zhang LH Youn HD Liu JO Inhibition of cell cycle progression by the novel cyclophilin ligand sanglifehrin A is mediated through the NFkappa B-dependent activation of p53 J Biol Chem 2001 276 43534 40
17. Zenke G Strittmatter U Fuchs S et al. Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action J Immunol 2001 166 7165 71
18. Allen A Zheng Y Gardner L Safford M Horton MR Powell JD The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction J Immunol 2004 172 4797 803
19. Steinschulte C Taner T Thomson AW Bein G Hackstein H Cutting edge: sanglifehrin A, a novel cyclophilin-binding immunosuppressant blocks bioactive IL-12 production by human dendritic cells J Immunol 2003 171 542 6
20. Härtel C Bein G Kirchner H Klüter H A human whole-blood assay for analysis of T-cell function by quantification of cytokine mRNA Scand J Immunol 1999 49 649 54
21. Härtel C Bein G Müller-Steinhardt M Klüter H Ex vivo induction of cytokine mRNA expression in human blood samples J Immunol Meth 2001 249 63 71
22. Hartwig D Härtel C Hennig H Müller-Steinhardt M Schlenke P Klüter H Evidence for de novo synthesis of cytokines and chemokines in platelet concentrates Vox Sang 2002 82 182 90
23. Schultz C Intracytoplasmic detection of proinflammatory cytokines and chemokines in monocytes by flow cytometry Methods Mol Biol 2003 215 29 39
24. Schultz C Rott C Temming P von Puttkammer J Bucsky P Influence of specimen age and use of different negative controls in determination of intracytoplasmic levels of cytokines after whole-blood culture assay Clin Diagn Lab Immunol 2002 9 295 8
25. Hammers HJ Kirchner H Schlenke P Ultraviolet-induced detection of halogenated pyrimidines. simultaneous analysis of DNA replication and cellular markers Cytometry 2000 40 327 35
26. Härtel C Fricke L Schumacher N Kirchner H Müller-Steinhardt M Delayed cytokine mRNA expression kinetics after T-lymphocyte costimulation: a quantitative measure of the efficacy of cyclosporin A-based immunosuppression Clin Chem 2002 48 2225 31
27. Härtel C Schumacher N Fricke L Ebel B Kirchner H Müller-Steinhardt M Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): impact of interleukin-2 mRNA expression as surrogate measure of immunosuppressive effect Clin Chem 2004 50 141 51
28. Ledbetter JA Imboden JB Schieven GL et al. CD28 ligation in T-cell activation: evidence for two signal transduction pathways Blood 1990 75 1531 9
29. Thompson CB Lindsten T Ledbetter JA et al. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines Proc Natl Acad Sci USA 1989 86 1333 7
30. Chaudhry S Freebern WJ Smith JL Butscher WG Haggerty CM Gardner K Cross-regulation of T cell growth factor expression by p53 and the Tax oncogene J Immunol 2002 169 6767 78
31. Cohen J The immunopathogenesis of sepsis Nature 2002 420 885 91