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Volumn 6, Issue 2, 2005, Pages 115-121

The emerging role of alemtuzumab in chronic lymphocytic leukemia

Author keywords

CD38; CD52; Cytogenetics; IgVH gene; Monoclonal antibodies; ZAP 70

Indexed keywords

ACICLOVIR; ALEMTUZUMAB; ANTIBIOTIC AGENT; CD38 ANTIGEN; CD52 ANTIGEN; COTRIMOXAZOLE; DIPHENHYDRAMINE; FAMCICLOVIR; FLUCONAZOLE; FLUDARABINE; GANCICLOVIR; HYDROCORTISONE; IMATINIB; PARACETAMOL; PETHIDINE; PROTEIN KINASE ZAP 70; PROTEIN P53; RITUXIMAB; STEROID; VALACICLOVIR; ANTINEOPLASTIC AGENT; CANCER ANTIBODY; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

EID: 33644846619     PISSN: 15579190     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLM.2005.n.037     Document Type: Review
Times cited : (11)

References (60)
  • 2
    • 0016740933 scopus 로고
    • Clinical staging of chronic lymphocytic leukemia
    • Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood 1975; 46:219-234.
    • (1975) Blood , vol.46 , pp. 219-234
    • Rai, K.R.1    Sawitsky, A.2    Cronkite, E.P.3
  • 3
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000; 343:1750-1757.
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 4
    • 1842455198 scopus 로고    scopus 로고
    • Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: Dawn of a new era
    • Nabhan C, Gartenhaus RB, Tallman MS. Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leuk Res 2004; 28:429-442.
    • (2004) Leuk Res , vol.28 , pp. 429-442
    • Nabhan, C.1    Gartenhaus, R.B.2    Tallman, M.S.3
  • 5
    • 0036534380 scopus 로고    scopus 로고
    • Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: Implications for clinical trials in this patient population
    • Perkins JG, Flynn JM, Howard RS, et al. Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: implications for clinical trials in this patient population. Cancer 2002; 94:2033-2039.
    • (2002) Cancer , vol.94 , pp. 2033-2039
    • Perkins, J.G.1    Flynn, J.M.2    Howard, R.S.3
  • 6
    • 0035524114 scopus 로고    scopus 로고
    • Improving the efficacy of antibody-based cancer therapies
    • Carter P. Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer 2001; 1:118-129.
    • (2001) Nat Rev Cancer , vol.1 , pp. 118-129
    • Carter, P.1
  • 7
    • 0842285686 scopus 로고    scopus 로고
    • Prognosis at diagnosis: Integrating molecular biologic insights into clinical practice for patients with CLL
    • Shanafelt TD, Geyer SM, Kay NE. Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL. Blood 2004; 103:1202-1210.
    • (2004) Blood , vol.103 , pp. 1202-1210
    • Shanafelt, T.D.1    Geyer, S.M.2    Kay, N.E.3
  • 9
    • 0032693874 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia
    • Keating MJ. Chronic lymphocytic leukemia. Semin Oncol 1999; 26:107-114.
    • (1999) Semin Oncol , vol.26 , pp. 107-114
    • Keating, M.J.1
  • 10
    • 0033106396 scopus 로고    scopus 로고
    • Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia
    • Hallek M, Langenmayer I, Nerl C, et al. Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia. Blood 1999; 93:1732-1737.
    • (1999) Blood , vol.93 , pp. 1732-1737
    • Hallek, M.1    Langenmayer, I.2    Nerl, C.3
  • 11
    • 0025319412 scopus 로고
    • Chromosome aberrations in B-cell chronic lymphocytic leukemia. Pathogenetic and clinical implications
    • Juliusson G, Gahrton G. Chromosome aberrations in B-cell chronic lymphocytic leukemia. Pathogenetic and clinical implications. Cancer Genet Cytogenet 1990; 45:143-160.
    • (1990) Cancer Genet Cytogenet , vol.45 , pp. 143-160
    • Juliusson, G.1    Gahrton, G.2
  • 12
    • 0025112785 scopus 로고
    • Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities
    • Juliusson G, Oscier DG, Fitchett M, et al. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med 1990; 323:720-724.
    • (1990) N Engl J Med , vol.323 , pp. 720-724
    • Juliusson, G.1    Oscier, D.G.2    Fitchett, M.3
  • 13
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343:1910-1916.
    • (2000) N Engl J Med , vol.343 , pp. 1910-1916
    • Dohner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 14
    • 0027436745 scopus 로고
    • p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
    • el Rouby S, Thomas A, Costin D, et al. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood 1993; 82:3452-3459.
    • (1993) Blood , vol.82 , pp. 3452-3459
    • el Rouby, S.1    Thomas, A.2    Costin, D.3
  • 15
    • 0028987180 scopus 로고
    • p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • Dohner H, Fischer K, Bentz M, et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 1995; 85:1580-1589.
    • (1995) Blood , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3
  • 16
    • 0037043653 scopus 로고    scopus 로고
    • Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy
    • Stilgenbauer S, Dohner H. Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy. N Engl J Med 2002; 347:452-453.
    • (2002) N Engl J Med , vol.347 , pp. 452-453
    • Stilgenbauer, S.1    Dohner, H.2
  • 17
    • 0345603747 scopus 로고    scopus 로고
    • Relative importance of CD38 expression over myeloid-associated markers expression in predicting the clinical course of B-CLL patients
    • Chang CC, Liu CZ, Cleveland RP. Relative importance of CD38 expression over myeloid-associated markers expression in predicting the clinical course of B-CLL patients. Leuk Lymphoma 2003; 44:977-982.
    • (2003) Leuk Lymphoma , vol.44 , pp. 977-982
    • Chang, C.C.1    Liu, C.Z.2    Cleveland, R.P.3
  • 18
    • 0141790879 scopus 로고    scopus 로고
    • CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells
    • Deaglio S, Capobianco A, Bergui L, et al. CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. Blood 2003; 102:2146-2155.
    • (2003) Blood , vol.102 , pp. 2146-2155
    • Deaglio, S.1    Capobianco, A.2    Bergui, L.3
  • 19
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94:1840-1947.
    • (1999) Blood , vol.94 , pp. 1840-1947
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 20
    • 0037355339 scopus 로고    scopus 로고
    • Prognostic significance of CD38 and CD20 expression as assessed by quantitative flow cytometry in chronic lymphocytic leukaemia
    • Hsi ED, Kopecky KJ, Appelbaum FR, et al. Prognostic significance of CD38 and CD20 expression as assessed by quantitative flow cytometry in chronic lymphocytic leukaemia. Br J Haematol 2003; 120:1017-1025.
    • (2003) Br J Haematol , vol.120 , pp. 1017-1025
    • Hsi, E.D.1    Kopecky, K.J.2    Appelbaum, F.R.3
  • 21
    • 0037441762 scopus 로고    scopus 로고
    • The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression
    • Ghia P, Guida G, Stella S, et al. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood 2003; 101:1262-1269.
    • (2003) Blood , vol.101 , pp. 1262-1269
    • Ghia, P.1    Guida, G.2    Stella, S.3
  • 22
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94:1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 23
    • 0034177538 scopus 로고    scopus 로고
    • Immunoglobulin V genes and CD38 expression in CLL
    • Hamblin TJ, Orchard JA, Gardiner A, et al. Immunoglobulin V genes and CD38 expression in CLL. Blood 2000; 95:2455-2457.
    • (2000) Blood , vol.95 , pp. 2455-2457
    • Hamblin, T.J.1    Orchard, J.A.2    Gardiner, A.3
  • 24
    • 0037103272 scopus 로고    scopus 로고
    • Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia
    • [published erratum in Blood 2002; 100:2291)
    • Lin K, Sherrington PD, Dennis M, et al. Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia [published erratum in Blood 2002; 100:2291). Blood 2002; 100:1404-1409.
    • (2002) Blood , vol.100 , pp. 1404-1409
    • Lin, K.1    Sherrington, P.D.2    Dennis, M.3
  • 25
    • 0037103257 scopus 로고    scopus 로고
    • Multivariate analysis of prognostic factors in CLL: Clinical stage, IgVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors
    • Oscier DG, Gardiner AC, Mould SJ, et al. Multivariate analysis of prognostic factors in CLL: clinical stage, IgVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood 2002; 100:1177-1184.
    • (2002) Blood , vol.100 , pp. 1177-1184
    • Oscier, D.G.1    Gardiner, A.C.2    Mould, S.J.3
  • 26
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348:1764-1775.
    • (2003) N Engl J Med , vol.348 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3
  • 27
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004; 351:893-901.
    • (2004) N Engl J Med , vol.351 , pp. 893-901
    • Rassenti, L.Z.1    Huynh, L.2    Toy, T.L.3
  • 28
    • 0037408455 scopus 로고    scopus 로고
    • Determining the clinical course and outcome in chronic lymphocytic leukemia
    • Rai KR, Chiorazzi N. Determining the clinical course and outcome in chronic lymphocytic leukemia. N Engl J Med 2003; 348:1797-1799.
    • (2003) N Engl J Med , vol.348 , pp. 1797-1799
    • Rai, K.R.1    Chiorazzi, N.2
  • 29
    • 0027240401 scopus 로고
    • Effect of Campath-1H antibody on human hematopoietic progenitors in vitro
    • Gilleece MH, Dexter TM. Effect of Campath-1H antibody on human hematopoietic progenitors in vitro. Blood 1993; 82:807-812.
    • (1993) Blood , vol.82 , pp. 807-812
    • Gilleece, M.H.1    Dexter, T.M.2
  • 30
    • 0028352208 scopus 로고
    • Immunohistochemical analysis of CDw52 antigen expression in non-Hodgkin's lymphomas
    • Salisbury JR, Rapson NT, Codd JD, et al. Immunohistochemical analysis of CDw52 antigen expression in non-Hodgkin's lymphomas. J Clin Pathol 1994; 47:313-317.
    • (1994) J Clin Pathol , vol.47 , pp. 313-317
    • Salisbury, J.R.1    Rapson, N.T.2    Codd, J.D.3
  • 32
    • 0024566393 scopus 로고
    • Effects of Campath-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype
    • Dyer MJ, Hale G, Hayhoe FG, et al. Effects of Campath-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype. Blood 1989; 73:1431-1439.
    • (1989) Blood , vol.73 , pp. 1431-1439
    • Dyer, M.J.1    Hale, G.2    Hayhoe, F.G.3
  • 33
    • 0023911111 scopus 로고
    • Reshaping human antibodies for therapy
    • Riechmann L, Clark M, Waldmann H, et al. Reshaping human antibodies for therapy. Nature 1988; 332:323-327.
    • (1988) Nature , vol.332 , pp. 323-327
    • Riechmann, L.1    Clark, M.2    Waldmann, H.3
  • 34
    • 0024204319 scopus 로고
    • Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody Campath-1H
    • Hale G, Dyer MJ, Clark MR, et al. Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody Campath-1H. Lancet 1988; 2:1394-1399.
    • (1988) Lancet , vol.2 , pp. 1394-1399
    • Hale, G.1    Dyer, M.J.2    Clark, M.R.3
  • 35
    • 0037106502 scopus 로고    scopus 로고
    • Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
    • Rai KR, Freter CE, Mercier RJ, et al. Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. J Clin Oncol 2002; 20:3891-3897.
    • (2002) J Clin Oncol , vol.20 , pp. 3891-3897
    • Rai, K.R.1    Freter, C.E.2    Mercier, R.J.3
  • 36
    • 79960971484 scopus 로고    scopus 로고
    • Efficacy and Safety of Alemtuzumab (Campath-1H) in refractory B-CLL patients treated on a compassionate basis
    • Rai K, Coutre S, Rizzeri D, et al. Efficacy and Safety of Alemtuzumab (Campath-1H) in refractory B-CLL patients treated on a compassionate basis. Blood 2001; 98:365a.
    • (2001) Blood , vol.98
    • Rai, K.1    Coutre, S.2    Rizzeri, D.3
  • 37
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood 2002; 99:3554-3561.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 38
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia
    • European Study Group of Campath-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A, Dyer MJ, Bunjes D, et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of Campath-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol 1997; 15:1567-1574.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 39
    • 0029937765 scopus 로고    scopus 로고
    • Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia
    • Osterborg A, Fassas AS, Anagnostopoulos A, et al. Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia. Br J Haematol 1996; 93:151-153.
    • (1996) Br J Haematol , vol.93 , pp. 151-153
    • Osterborg, A.1    Fassas, A.S.2    Anagnostopoulos, A.3
  • 40
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J, Kimby E, Bjorkholm M, et al. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 2002; 100:768-773.
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3
  • 41
    • 0038315030 scopus 로고    scopus 로고
    • Patients with refractory B-CLL and T-PLL treated with alemtuzumab in a compassionate basis, a report on efficacy and safety of CAM-511 trial
    • (Abstract #1538)
    • Rai K, Keating M. Patients with refractory B-CLL and T-PLL treated with alemtuzumab in a compassionate basis, a report on efficacy and safety of CAM-511 trial. Blood 2002; 100(suppl):802a (Abstract #1538).
    • (2002) Blood , vol.100 , Issue.SUPPL.
    • Rai, K.1    Keating, M.2
  • 42
    • 0030300084 scopus 로고    scopus 로고
    • Immunosuppressive toxicity of Campath1H monoclonal antibody in the treatment of patients with recurrent low grade lymphoma
    • Tang SC, Hewitt K, Reis MD, et al. Immunosuppressive toxicity of Campath1H monoclonal antibody in the treatment of patients with recurrent low grade lymphoma. Leuk Lymphoma 1996; 24:93-101.
    • (1996) Leuk Lymphoma , vol.24 , pp. 93-101
    • Tang, S.C.1    Hewitt, K.2    Reis, M.D.3
  • 43
    • 0036753610 scopus 로고    scopus 로고
    • Cytomegalovirus viremia during Campath-1H therapy for relapsed and refractory chronic lymphocytic leukemia and prolymphocytic leukemia
    • Nguyen DD, Cao TM, Dugan K, et al. Cytomegalovirus viremia during Campath-1H therapy for relapsed and refractory chronic lymphocytic leukemia and prolymphocytic leukemia. Clin Lymphoma 2002; 3:105-110.
    • (2002) Clin Lymphoma , vol.3 , pp. 105-110
    • Nguyen, D.D.1    Cao, T.M.2    Dugan, K.3
  • 44
    • 11144357712 scopus 로고    scopus 로고
    • Management guidelines for use of alemtuzumab in B-cell chronic lymphocytic leukemia
    • Keating M, Course S, Rai K, et al. Management guidelines for use of alemtuzumab in B-cell chronic lymphocytic leukemia. Clin Lymphoma 2004; 4:220-227.
    • (2004) Clin Lymphoma , vol.4 , pp. 220-227
    • Keating, M.1    Course, S.2    Rai, K.3
  • 45
    • 0031027623 scopus 로고    scopus 로고
    • Subcutaneous Campath-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia
    • Bowen AL, Zomas A, Emmett E, et al. Subcutaneous Campath-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia. Br J Haematol 1997; 96:617-619.
    • (1997) Br J Haematol , vol.96 , pp. 617-619
    • Bowen, A.L.1    Zomas, A.2    Emmett, E.3
  • 46
    • 0037085770 scopus 로고    scopus 로고
    • Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia
    • Kennedy B, Rawstron A, Carter C, et al. Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia. Blood 2002; 99:2245-2247.
    • (2002) Blood , vol.99 , pp. 2245-2247
    • Kennedy, B.1    Rawstron, A.2    Carter, C.3
  • 47
    • 0037639577 scopus 로고    scopus 로고
    • Development of a new, four weekly schedule (Flucam) with concomittant application of Campath-1H and fludarabine in patients with relapsed /refractory CLL
    • (Abstract #3169)
    • Elter T, Brochmann P, Jensen M, et al. Development of a new, four weekly schedule (Flucam) with concomittant application of Campath-1H and fludarabine in patients with relapsed/refractory CLL. Blood 2002; 100(suppl):803a (Abstract #3169).
    • (2002) Blood , vol.100 , Issue.SUPPL.
    • Elter, T.1    Brochmann, P.2    Jensen, M.3
  • 48
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D, von Schilling C, Wilhelm M, et al. Rituximab therapy of patients with B-cell chronic lymphocytic: leukemia. Blood 2001; 98:1326-1331.
    • (2001) Blood , vol.98 , pp. 1326-1331
    • Huhn, D.1    von Schilling, C.2    Wilhelm, M.3
  • 49
    • 0037297390 scopus 로고    scopus 로고
    • First-line and maintenance treatment with rituximab, for patients with indolent non-Hodgkin's lymphoma
    • Hainsworth JD. First-line and maintenance treatment with rituximab, for patients with indolent non-Hodgkin's lymphoma. Semin Oncol 2003; 30(1 suppl. 2): 9-15.
    • (2003) Semin Oncol , vol.30 , Issue.1 SUPPL. 2 , pp. 9-15
    • Hainsworth, J.D.1
  • 50
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd JC, Murphy T, Howard RS, et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 2001; 19:2153-2164.
    • (2001) J Clin Oncol , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3
  • 51
    • 0035871441 scopus 로고    scopus 로고
    • Rituximab dose-escalation trial in chronic lymphocytic leukemia
    • O'Brien SM, Kantarjian H, Thomas DA, et al. Rituximab dose-escalation trial in chronic lymphocytic: leukemia. J Clin Oncol 2001; 19:2165-2170.
    • (2001) J Clin Oncol , vol.19 , pp. 2165-2170
    • O'Brien, S.M.1    Kantarjian, H.2    Thomas, D.A.3
  • 52
    • 0036179094 scopus 로고    scopus 로고
    • Conceptual aspects of combining rituximab and Campath-1H in the treatment of chronic lymphocytic leukemia
    • Nabhan C, Rosen ST. Conceptual aspects of combining rituximab and Campath-1H in the treatment of chronic lymphocytic leukemia. Semin Oncol 2002; 29(1 suppl 2):75-80.
    • (2002) Semin Oncol , vol.29 , Issue.1 SUPPL. 2 , pp. 75-80
    • Nabhan, C.1    Rosen, S.T.2
  • 53
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies
    • Faderl S, Thomas DA, O'Brien S, et al. Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood 2003; 101:3413-3415.
    • (2003) Blood , vol.101 , pp. 3413-3415
    • Faderl, S.1    Thomas, D.A.2    O'Brien, S.3
  • 54
    • 8644274039 scopus 로고    scopus 로고
    • A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL)
    • Nabhan C, Patton D, Gordon LI, et al. A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL). Leuk Lymphoma 2004; 45:2269-2273.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2269-2273
    • Nabhan, C.1    Patton, D.2    Gordon, L.I.3
  • 55
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996; 87:4990-4997.
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3
  • 56
    • 0035412369 scopus 로고    scopus 로고
    • Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy
    • Rawstron AC, Kennedy B, Evans PA, et al. Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Blood 2001; 98:29-35.
    • (2001) Blood , vol.98 , pp. 29-35
    • Rawstron, A.C.1    Kennedy, B.2    Evans, P.A.3
  • 57
    • 9544236183 scopus 로고    scopus 로고
    • Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation
    • Provan D, Bartlett-Pandite L, Zwicky C, et al. Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation. Blood 1996; 88:2228-2235.
    • (1996) Blood , vol.88 , pp. 2228-2235
    • Provan, D.1    Bartlett-Pandite, L.2    Zwicky, C.3
  • 58
    • 0344236261 scopus 로고    scopus 로고
    • Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia
    • O'Brien SM, Kantarjian HM, Thomas DA, et al. Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia. Cancer 2003; 98:2657-2663.
    • (2003) Cancer , vol.98 , pp. 2657-2663
    • O'Brien, S.M.1    Kantarjian, H.M.2    Thomas, D.A.3
  • 59
    • 21144456107 scopus 로고    scopus 로고
    • Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival
    • Moreton P, Kennedy B, Lucas G, et al. Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival. J Clin Oncol 2005; 23:2971-2979.
    • (2005) J Clin Oncol , vol.23 , pp. 2971-2979
    • Moreton, P.1    Kennedy, B.2    Lucas, G.3
  • 60
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood 2004; 103:3278-3281.
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.