-
1
-
-
0345689346
-
Farnesyl transferase inhibitors in hematologic malignancies: New horizons in therapy
-
Lancet JE, Karp JE. Farnesyl transferase inhibitors in hematologic malignancies: new horizons in therapy. Blood 2003;102:4512-4519.
-
(2003)
Blood
, vol.102
, pp. 4512-4519
-
-
Lancet, J.E.1
Karp, J.E.2
-
2
-
-
8644219632
-
Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: Possible mechanisms of action
-
Jabbour E, Kantarjian H, Cortes J. Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: possible mechanisms of action. Leuk Lymphoma 2004; 45:2187-2195.
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 2187-2195
-
-
Jabbour, E.1
Kantarjian, H.2
Cortes, J.3
-
3
-
-
0142061051
-
Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes
-
Cortes J. Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes. Clin Lymphoma 2003;4(suppl 1):S30-S35.
-
(2003)
Clin Lymphoma
, vol.4
, Issue.SUPPL. 1
-
-
Cortes, J.1
-
4
-
-
1342331479
-
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors
-
Sebti SM, Der CJ. Opinion: searching for the elusive targets of farnesyltransferase inhibitors. Nat Rev Cancer 2003;3: 945-951.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 945-951
-
-
Sebti, S.M.1
Der, C.J.2
-
5
-
-
4444314787
-
R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways
-
Beaupre DM, Cepero E, Obeng EA, et al. R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways. Mol Cancer Ther 2004;3:179-186.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 179-186
-
-
Beaupre, D.M.1
Cepero, E.2
Obeng, E.A.3
-
6
-
-
23044465584
-
Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-Chloro-3,10-dibromo-6,11- dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl) -2-oxo-ethyl)-1 -piperidinecarboxamide (SCH66336)
-
Bruzek LM, Poynter JN, Kaufmann SH, Adjei AA. Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)- cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1 -piperidinecarboxamide (SCH66336). Mol Pharmacol 2005;68:477-486.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 477-486
-
-
Bruzek, L.M.1
Poynter, J.N.2
Kaufmann, S.H.3
Adjei, A.A.4
-
7
-
-
0036738122
-
Farnesyl transferase inhibitor R115777 induces apoptosis of human myeloma cells
-
Le Gouill S, Pellat-Deceunynck C, Harousseau JL, et al. Farnesyl transferase inhibitor R115777 induces apoptosis of human myeloma cells. Leukemia 2002;16:1664-1667.
-
(2002)
Leukemia
, vol.16
, pp. 1664-1667
-
-
Le Gouill, S.1
Pellat-Deceunynck, C.2
Harousseau, J.L.3
-
8
-
-
0035383789
-
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial
-
Karp JE, Lancet JE, Kaufmann SH, et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood 2001;97: 3361-3369.
-
(2001)
Blood
, vol.97
, pp. 3361-3369
-
-
Karp, J.E.1
Lancet, J.E.2
Kaufmann, S.H.3
-
9
-
-
13144296650
-
Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia
-
Raponi M, Belly RT, Karp JE, et al. Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia. BMC Cancer 2004;4:56.
-
(2004)
BMC Cancer
, vol.4
, pp. 56
-
-
Raponi, M.1
Belly, R.T.2
Karp, J.E.3
-
10
-
-
25844463711
-
Tipifarnib (Zarnestra) in previously untreated poor-risk AML of the elderly: Updated results of a multi-center phase 2 trial
-
Lancet JE, Gotlib J, Gojo I, et al. Tipifarnib (Zarnestra) in previously untreated poor-risk AML of the elderly: Updated results of a multi-center phase 2 trial. Blood 2004; 104:249a.
-
(2004)
Blood
, vol.104
-
-
Lancet, J.E.1
Gotlib, J.2
Gojo, I.3
-
11
-
-
17144361932
-
Farnesyltransferase inhibitor therapy in acute myelogenous leukemia
-
Gotlib J. Farnesyltransferase inhibitor therapy in acute myelogenous leukemia. Curr Hematol Rep 2005;4:77-84.
-
(2005)
Curr Hematol Rep
, vol.4
, pp. 77-84
-
-
Gotlib, J.1
-
12
-
-
2142712474
-
Phase I study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome
-
Kurzrock R, Albitar M, Cortes J, et al. Phase I study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome. J Clin Oncol 2004:22:1287-1292.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1287-1292
-
-
Kurzrock, R.1
Albitar, M.2
Cortes, J.3
-
13
-
-
10744227474
-
Farnesyltransferase inhibitor R115777 in myelodysplastic syndromes: Clinical and biologic activities in the phase 1 setting
-
Kurzrock R, Kantarjian HM, Cortes JE, et al. Farnesyltransferase inhibitor R115777 in myelodysplastic syndromes: Clinical and biologic activities in the phase 1 setting. Blood 2003; 102:4527-4534.
-
(2003)
Blood
, vol.102
, pp. 4527-4534
-
-
Kurzrock, R.1
Kantarjian, H.M.2
Cortes, J.E.3
-
14
-
-
23844505374
-
Farnesyltransferase inhibitors in myelodysplastic syndrome
-
Feldman EJ. Farnesyltransferase inhibitors in myelodysplastic syndrome. Curr Hematol Rep 2005:4:186-190.
-
(2005)
Curr Hematol Rep
, vol.4
, pp. 186-190
-
-
Feldman, E.J.1
-
15
-
-
0141956034
-
CMML: A biologically distinct myeloproliferative disease
-
Cortes J. CMML: A biologically distinct myeloproliferative disease. Curr Hematol Rep 2003;2:202-208.
-
(2003)
Curr Hematol Rep
, vol.2
, pp. 202-208
-
-
Cortes, J.1
-
16
-
-
0037372488
-
Efficacy of farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
-
Cortes J, Albitar M, Thomas D, et al. Efficacy of farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies. Blood 2003;101: 1692-1697.
-
(2003)
Blood
, vol.101
, pp. 1692-1697
-
-
Cortes, J.1
Albitar, M.2
Thomas, D.3
-
17
-
-
0037255947
-
Advanced-phase chronic myeloid leukemia
-
Cortes J, Kantarjian H. Advanced-phase chronic myeloid leukemia. Semin Hematol 2003;40:79-86.
-
(2003)
Semin Hematol
, vol.40
, pp. 79-86
-
-
Cortes, J.1
Kantarjian, H.2
-
18
-
-
0037514395
-
In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia
-
Mesa RA, Tefferi A, Gray LA, et al. In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia. Leukemia 2003;17: 849-855.
-
(2003)
Leukemia
, vol.17
, pp. 849-855
-
-
Mesa, R.A.1
Tefferi, A.2
Gray, L.A.3
-
19
-
-
28444434844
-
A Phase I study of Tipifarnib in combination with imatinib (IM) for patients with chronic myeloid leukemia in chronic phase who failed IM therapy
-
Cortes J, Garcia-Manero G, O'Brien S, et al. A Phase I study of Tipifarnib in combination with imatinib (IM) for patients with chronic myeloid leukemia in chronic phase who failed IM therapy. Blood 2004;104:289a.
-
(2004)
Blood
, vol.104
-
-
Cortes, J.1
Garcia-Manero, G.2
O'Brien, S.3
-
20
-
-
28444434844
-
Phase I study of lonafarnib (SCH66336) in combination with imatinib for patients with chronic myeloid leukemia after failure with imatinib
-
Cortes J, O'Brien S, Verstovek S, et al. Phase I study of lonafarnib (SCH66336) in combination with imatinib for patients with chronic myeloid leukemia after failure with imatinib. Blood 2004;104:288a.
-
(2004)
Blood
, vol.104
-
-
Cortes, J.1
O'Brien, S.2
Verstovek, S.3
-
21
-
-
0037762630
-
Towards combination target-directed chemotherapy for chronic myeloid leukemia: Role of farnesyl transferase inhibitors
-
Daley GQ. Towards combination target-directed chemotherapy for chronic myeloid leukemia: Role of farnesyl transferase inhibitors. Semin Hematol 2003;40(suppl 2):11-14.
-
(2003)
Semin Hematol
, vol.40
, Issue.SUPPL. 2
, pp. 11-14
-
-
Daley, G.Q.1
-
22
-
-
11144358447
-
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
-
Alsina M, Fonseca R, Wilson EF, et al. Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Blood 2004;103:3271-3277.
-
(2004)
Blood
, vol.103
, pp. 3271-3277
-
-
Alsina, M.1
Fonseca, R.2
Wilson, E.F.3
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