On the thermal decomposition of dipyridamole: Thermogravimetric, differential scanning calorimetric and spectroscopic studies

Spectroscopy Letters

Volumn 39, Issue 2, 2006, Pages 145-161

  Silva Oliveira, Marilene ^a   Miguel Agustinho, Sylvana Cardoso ^a   De Guzzi Plepis, Ana Maria ^a   Tabak, Marcel ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Dipyridamole; DSC; Fluorescence emission spectroscopy; IR; NMR spectroscopy; Optical absorption spectroscopy; TG; Thermal decomposition

Indexed keywords

EID: 33644841401     PISSN: 00387010     EISSN: 15322289     Source Type: Journal    
DOI: 10.1080/00387010500531126     Document Type: Article

References (23)

1. Steinberg, D, Workshop Participants Circulation. Antioxidants in the prevention of human artherosclerosis. Circulation 1992, 85, 2338-2344.
2. Fitzgerald, G. A. Dipyridamole. N. Engl. J. Med. 1987, 316 (20), 1247-1257.
3. Batista, E.; del Prado, J.; Almirall, L.; Jamieson, G. A.; Ordinas, A. Inhibitory effects of dipyridamole on growth, nucleoside incorporation, and platelet-activating capability in the U87MG and SKNMC human tumor cell lines. Cancer Res. 1985, 5 (9), 4048-4052.
4. Kang, G. J.; Kimball, A. P. Dipyridamole enhancement of toxicity to L1210 cells by deoxyadenosine and deoxycoformycin combinations in vitro. Cancer Res. 1984, 44 (2), 461-466.
5. Asoh, K.; Saburi, Y.; Sato, S.; Nogae, I.; Kohno, K.; Kuwano, M. Potentiation of some anticancer agents by dipyridamole against drug-sensitive and drug-resistant cancer cell-lines. Jpn. J. Cancer Res. 1989, 80 (5), 475-481.
6. Zhen, Y. S.; Taniki, T.; Weber, G. Azidothymidine and dipyridamole as biochemical response modifiers - synergism with methotrexate and 5-fluorouracil in human colon and pancreatic-carcinoma cells. Oncology Res. 1992, 4 (2), 73-78.
7. Iuliano, L.; Violi, F.; Ghiselli, A.; Alessandri, C.; Balsamo, F. Dipyridamole inhibits lipid-peroxidation and scavenges oxygen radicals. Lipids 1989, 24 (5), 430-433.
8. Pedulli, G. F.; Lucarini, M.; Marchesi, E.; Paolucci, F.; Roffia, S.; Fiorentini, D.; Landi, L. Medium effects on the antioxidant activity of dipyridamole. Free Radical Biol. Med. 1999, 26 (3-4), 295-302.
9. Borisevitch, I. E.; Tabak, M. Electronic absorption and fluorescence spectroscopic studies of dipyridamole - effects of solution composition. J. Lumin. 1992, 51 (6), 315-322.
10. Borissevitch, I. E.; Borges, C. P. F.; Borissevitch, G. P.; Yushmanov, V. E.; Louro, S. R. W.; Tabak, M. Binding and location of dipyridamole derivatives in micelles: the role of drug molecular structure and charge. Z Naturforsch. C Biosci. 1996, 51 (7-8), 578-590.
11. Borges, C. P. F.; Tabak, M. Spectroscopic studies of dipyridamole derivatives in homogeneous solutions - effects of solution composition on the electronic absorption and emission. Spectrochim. Acta A 1994, 50 (6), 1047-1056.
12. Almeida, L. E.; Castilho, M.; Mazo, L. H.; Tabak, M. Voltammetric and spectroscopic studies of the oxidation of the anti-oxidant drug dipyridamole in acetonitrile and ethanol. Anal. Chim. Acta 1998, 375 (3), 223-231.
13. Castilho, M.; Almeida, L. E.; Tabak, M.; Mazo, L. H. The electrochemical oxidation of the antioxidant drug dipyridamole at glassy carbon and graphite electrodes in micellar solutions. Electrochim. Acta 2000, 46 (1), 67-75.
14. Berbenni, V.; Marini, A.; Bruni, G.; Maggioni, A.; Cogliati, P. Thermoanalytical and spectroscopic characterization of solid state dipyridamole. J. Therm. Anal. Calorim. 2002, 68 (2), 413-422.
15. 4. Acta Crystallogr. Sect. C Cryst. Struct. 1983, 39, 1454-1458.
16. Castilho, M.; Almeida, A. M. P.; Almeida, L. E.; Tabak, M.; Mazo, L. H. The electrooxidation of dipyridamole derivatives in acetonitrile solution. J. Eletroanal. Chem. 2002, 528 (1-2), 175-183.
17. The Merck Index, Twelfth edition; Merck: Whitehouse Station, NJ, 1996.
18. Borde, B.; Cesáro, A. A DSC study of hydrated sugar alcohols. Isomalt J. Therm. Anal. Calorim. 2001, 66, 179-195.
19. Nepomuceno, M. F.; Alonso, A.; Pereira-da-Silva, L.; Tabak, M. Inhibitory effect of dipyridamole and its derivatives on lipid peroxidation in mitochondria. Free Radic. Biol. Med. 1997, 23 (7), 1046-1054.
20. Borges, C. P. F.; Honda, S.; Berlinck, R. G. S.; Imasato, H.; Berci Filho, P.; Tabak, M. Synthesis, characterization and interaction with ionic micelles of tetraacetylated dipyridamole. Spectrochim. Acta A 1995, 51 (14), 2575-2584.
21. Silvernstein, R. M.; Bassler, G. C.; Morril, T. C. Spectrometric Identification of Organic Compounds, 5th ed.; Wiley: New York, 1991.
22. Brasileiro, A. M. P. Ph.D. thesis, Instituto de Química de São Carlos, Universidade de São Paulo: São Carlos, 2001.
23. Barberiheyob, M.; Merlin, J. L.; Pons, L.; Calco, M.; Weber, B. A. A sensitive isocratic liquid-chromatography assay for the determination of dipyridamole in plasma with electrochemical detection. J. Liq. Chromatogr. 1994, 17 (8), 1837-1848.