Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 2, 2006, Pages

  Sparkman, Loretta ^a   Chandru, Hemakumar ^a   Boggaram, Vijayakumar ^a,b  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^b Dept of Molecular Biology ^*  (United States)

Author keywords

Inflammation; Lung injury; Sphingolipids; Thyroid transcription factor 1; Transcription

Indexed keywords

BISINDOLYLMALEIMIDE; CERAMIDE; DEXAMETHASONE; GENISTEIN; MESSENGER RNA; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SURFACTANT PROTEIN B; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; DNA; DRUG DERIVATIVE; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; LYSOPHOSPHOLIPID; N ACETYLSPHINGOSINE; N-ACETYLSPHINGOSINE; NUCLEAR PROTEIN; SPHINGOSINE 1-PHOSPHATE; THYROID NUCLEAR FACTOR 1;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA BINDING; DOSE RESPONSE; DOWN REGULATION; DRUG BINDING; DRUG EFFECT; DRUG INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENE MAPPING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; LUNG TUMOR; METABOLISM; PHYSIOLOGY;

DNA; DOWN-REGULATION; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; HUMANS; LUNG NEOPLASMS; LYSOPHOSPHOLIPIDS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; PULMONARY SURFACTANT-ASSOCIATED PROTEIN B; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 33644836488     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00275.2005     Document Type: Article

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