Corneal ulceration and perforation with ketorolac tromethamine (Acular®) use after PRK

Cornea

Volumn 25, Issue 2, 2006, Pages 232-234

  Mian, Shahzad I ^a   Gupta, Anjali ^a   Pineda II, Roberto ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

Acular ; Corneal perforation; Ketorolac tromethamine; NSAID; PRK

Indexed keywords

CEFTAZIDIME; CIPROFLOXACIN; KETOROLAC TROMETAMOL; PREDNISOLONE ACETATE; VANCOMYCIN;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; CORNEA PERFORATION; CORNEA ULCER; DRUG EFFECT; DRUG MEGADOSE; ERYTHEMA; EYE PAIN; HUMAN; KERATOMETRY; MALE; MYOPIA; PATIENT COUNSELING; PENETRATING KERATOPLASTY; PHOTOREFRACTIVE KERATECTOMY; PRIORITY JOURNAL; SCHIRMER TEST; SLIT LAMP; VISUAL IMPAIRMENT;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CORNEA; CORNEAL ULCER; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLLOW-UP STUDIES; HUMANS; KERATECTOMY, PHOTOREFRACTIVE, EXCIMER LASER; KERATOPLASTY, PENETRATING; KETOROLAC TROMETHAMINE; MALE; OPHTHALMIC SOLUTIONS; POSTOPERATIVE COMPLICATIONS; REOPERATION; RUPTURE, SPONTANEOUS;

EID: 33644836124     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ico.0000179931.05275.dd     Document Type: Article

References (26)

1. Weinstock VM, Weinstock DJ, Weinstock SJ. Diclofenac and ketorolac in the treatment of pain after photorefractive keratectomy. J Refract Surg. 1996;12:792-794.
2. Nichols J, Snyder RW. Topical nonsteroidal anti-inflammatory agents in ophthalmology. Curr Opin Ophthalmol. 1998;9:40-44.
3. Rajpal RK, Cooperman BB. Analgesic efficacy and safety of ketorolac after photorefractive keratectomy. J Refract Surg. 1999;15:661-667.
4. Vetrugno M. Maineo A, Quaranta GM. et al. A randomized, double-masked, clinical study of the efficacy of four nonsteroidal anti-inflammatory drugs in pain control after excimer laser photorefractive keratectomy. Clin Ther. 2000;22:719-731.
5. Sun R, Gimbel HV. Effects of topical ketorolac and diclofenac on normal corneal sensation. J Refract Surg. 1997;13:158-161.
6. Gills JP. Voltaren associated with medication keratitis (letter). J Cataract Refract Surg. 1994;20:110.
7. Probst LE, Machat JJ. Corneal subepithelial infiltrates following photorefractive keratectomy (letter). J Cataract Refract Surg. 1996;22:281.
8. Shizmazaki J, Saito H, Yang H-Y, et al. Persistent epithelial defects following penetrating keratoplasty: an adverse effect of diclofenac cyedrops. Cornea. 1995;14:623-627.
9. Guidera AC, Luchs JI. Udell U. Keratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs. Ophthalmology. 2001;108:936-944.
10. Lin JC, Rapuano CJ, Laibson PR, et al. Corneal melting associated with use of topical nonsteroidal anti-inflammatory drugs after ocular surgery. Arch Ophthalmol. 2000;118:1129-1132.
11. Congdon NG, Schein OD, von Kulajta P, et al. Corneal complications associated with topical ophthalmic use of nonsteroidal anti-inflammatory drugs. J Cataract Refract Surg. 2001;27:622-631.
12. Hargrave SL, Jung JC, Fini ME, et al. Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: an analysis of postoperative keratolysis. Ophthalmology. 2002;109:343-350.
13. Teal P, Breslin C, Arshinoff S, et al. Corneal subepithelial infiltrates following excimer laser photorefractive keratectomy. J Cataract Refract Surg. 1995;21:516-521.
14. Acular® (ketorolac tromethamine ophthalmic solution) 0.5% Sterile [Allergan download]. Available at: http://www.allergan.com/download/ Acular_P12002.pdfAcular. Accessed July 1. 2004.
15. Phillips AF, Hayashi S, Seitz B, et al. Effect of diclofenac, ketorolac, and fluorometholone on arachidonic acid metabolites following excimer laser corneal surgery. Arch Ophthalmol. 1996;114:1495-1498.
16. Chen X, Gallar J, Belmonte C. Reduction by antiinflammatory drugs of the response of corneal sensory nerve fibers to chemical irritation. Invest Ophthalmol Vis Sci. 1997;38:1944-1953.
17. Aragona P, Stilo A, Ferreri F, et al. Effects of the topical treatment with NSAIDs on corneal sensitivity and ocular surface of Sjogren's syndrome patients. Eye advance online publication 21 May 2004.
18. Aragona P, Tripodi G, Spinella R, et al. The effects of the topical administration of non-steroidal anti-inflammatory drugs on corneal epithelium and corneal sensitivity in normal subjects. Eye. 2000;14: 206-210.
19. Seitz B, Sorken K, LaBree LD, et al. Corneal sensitivity and burning sensation. Comparing topical ketorolac and diclofenac. Arch Ophthalmol. 1996;114:921-924.
20. Szerenyi K, Sorken K, Garbus JJ, et al. Decrease in normal human corneal sensitivity with topical diclofenac sodium. Am J Ophthalmol. 1994;118: 312-315.
21. Reviglio VE, Rana TS, Li QJ, et al. Effects of topical nonsteroidal anti-inflammatory drugs on the expression of matrix metalloproteinases in the cornea. J Cataract Refract Surg. 2003;29:989-997.
22. Lu X, Xie W, Reed D, et al. Nonsteroidal anti-inflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts. Proc Natl Acad Sci USA. 1995;92:7961-7965.
23. Waterbury L, Kunysz EA, Beuerman R. Effects of steroidal and non-steroidal anti-inflammatory agents on corneal wound healing. J Ocul Pharmacol. 1987;3:43-54.
24. McGhee CN, Dean S, Danesh-Meyer H. Locally administered ocular corticosteroids: benefits and risks. Drug Saf. 2002;25:33-55.
25. Bertolini A, Ottani A, Sandrini M. Dual acting anti-inflammatory drugs: a reappraisal. Pharmacol Res. 2001;44:437-450.
26. Gilroy DW, Tomlison A, Willoughby DA. Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation. Eur J Pharmacol. 1998;355:211-217.