A randomized, double-masked, clinical study of the efficacy of four nonsteroidal anti-inflammatory drugs in pain control after excimer laser photorefractive keratectomy

Clinical Therapeutics

Volumn 22, Issue 6, 2000, Pages 719-731

  Vetrugno, Michele ^a   Maino, Anna ^a   Quaranta, Grazia Maria ^a   Cardia, Luigi ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Analgesia; Diclofenac; Flurbiprofen; Indomethacin; Ketorolac; Photorefractive keratectomy

Indexed keywords

CARBOXYMETHYLCELLULOSE; DICLOFENAC; EXOCIN; FLURBIPROFEN; INDOCOLLIRIO; INDOMETACIN; KETOROLAC; KETOROLAC TROMETAMOL; LIXIDOL; NONSTEROID ANTIINFLAMMATORY AGENT; NOVESINA; PLACEBO;

ADULT; ANALGESIA; ARTICLE; ASTIGMATISM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EPITHELIZATION; FEMALE; HUMAN; KERATECTOMY; MAJOR CLINICAL STUDY; MALE; MYOPIA; POSTOPERATIVE PAIN; PRURITUS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 0033919218     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(00)90006-7     Document Type: Article

References (33)

1. 1. Baek SH, Choi SY, Chang JH, et al. Short-term effects of flurbiprofen and diclofenac on refractive outcome and corneal haze after photorefractive keratectomy. J Cataract Refractive Surg. 1997;23:1317-1323.
2. 2. Assouline M, Moosavi J, Muller-Steinwachs M, et al. PMMA model of steep central islands induced by excimer laser photorefractive keratectomy. Surv Ophthalmol. 1997;42(Suppl 1):S35-S51.
3. 3. Assouline M, Renard G, Arne JL, et al. A prospective randomized trial of topical soluble 0.1% indomethacin versus 0.1% diclofenac versus placebo for the control of pain following excimer laser photorefractive keratectomy. Ophthalmic Surg Lasers. 1998;29:365-374.
4. 4. Rajpal RK, Cooperman BB, for the Ketorolac Study Group. Analgesic efficacy and safety of ketorolac after photorefractive keratectomy. J Refractive Surg. 1999; 15:661-667.
5. 5. Corbett MC, O'Brart DPS, Marshall J. Do topical corticosteroids have a role following excimer laser photorefractive keratectomy? J Refractive Surg. 1995;11:380-387.
6. 6. Cherry PMH, Tutton MR, Adikary H, et al. The treatment of pain following photorefractive keratectomy. J Refractive Corneal Surg. 1994;10(Suppl):S222-S225.
7. 7. Phillips AF, Szerenyi K, Campos M, et al. Arachidonic acid metabolites after excimer laser corneal surgery. Arch Ophthalmol. 1993;111:1273-1278.
8. 8. Gartry DS, Kerr-Muir MG, Lohmann CP, Marshall J. The effect of topical corticosteroids on refractive outcome and corneal haze after photorefractive keratectomy. Arch Ophthalmol. 1992;110:944-952.
9. 9. Waldrep JC. Neurogenic inflammation of the cornea. In: Beuerman RW, Crosson CE, Kaufman HE, eds. Healing Processes in the Cornea. Houston, Tex: Gulf Publishing; 1989:27-44.
10. 10. Arshinoff SA, Mills MD, Haber S. Pharmacotherapy of photorefractive keratectomy. J Cataract Refractive Surg. 1996; 22:1037-1044.
11. 11. Nassaralla BA, Szerenyi K, Wang XW, et al. Effect of diclofenac on corneal haze after photorefractive keratectomy. Ophthalmology. 1995;102:469-474.
12. 12. Sher NA, Frantz JM, Talley A, et al. Topical diclofenac in the treatment of ocular pain after excimer photorefractive keratectomy. Refractive Corneal Surg. 1993;9: 425-436.
13. 13. Seitz B, Sorken K, LaBree LD, et al. Corneal sensitivity and burning sensation. Comparing topical ketorolac and diclofenac. Arch Ophthalmol. 1996;114:921-924.
14. 14. Hettinger ME, Gill DJ, Robin JB, et al. Evaluation of diclofenac sodium 0.1% ophthalmic solution in the treatment of ocular symptoms after bilateral radial keratectomy. Cornea. 1997;16:406-413.
15. 15. Epstein RL, Laurence EP. Effect of topical diclofenac solution on discomfort after radial keratectomy. J Cataract Refractive Surg. 1994;20:378-380.
16. 16. Goes F, Richard C, Trinquand C. Comparative study of two non-steroidal anti-inflammatory eyedrops, 0.1% indomethacin versus 0.1% diclofenac in pain control post photorefractive keratectomy. Bull Soc Belge Ophtalmol. 1997;267:11-19.
17. 17. Weinstock VM, Weinstock DJ, Weinstock SJ. Diclofenac and ketorolac in the treatment of pain after photorefractive keratectomy. J Refractive Surg. 1996;12:792-794.
18. 18. Appiotti A, Gualdi L, Alberti M, Gualdi M. Comparative study of the analgesic efficacy of flurbiprofen and diclofenac in patients following excimer laser photorefractive keratectomy. Clin Ther. 1998;20:913-920.
19. 19. Beuerman RW, McDonald MB, Zhang D, et al. Diclofenac sodium attenuates neural activity after photorefractive keratectomy in rabbits. J Refractive Surg. 1996;12: 783-791.
20. 20. Phillips AF, Hagashi S, Seitz B, et al. Effect of diclofenac, ketorolac and fluorometholone on arachidonic acid metabolites following excimer corneal surgery. Arch Ophthalmol. 1996;114:1495-1498.
21. 21. Melzack R. The McGill Pain Questionnaire: Major properties and scoring methods. Pain. 1975;1:277-299.
22. 22. Holladay JT, Prager TC. Mean visual acuity. Am J Ophthalmol. 1991;111:372-374.
23. 23. Schwartz-Goldstein BH, Hersh PS. The Summit PRK Topography group. Corneal topography of phase III excimer laser photorefractive keratectomy: Optical zone centration analysis. Ophthalmology. 1995; 102:951-962.
24. 24. Trockel SL, Munnerlyn C. Excimer ophthalmic delivery systems. Lasers Light Ophthalmol. 1989;2:157-161.
25. 25. Glantz SA. Primer of Biostatistics. 4th ed. New York, NY: McGraw-Hill, Inc.; 1997:67-85.
26. 26. Dowdy S, Wearden S. Statistics for Research. New York, NY: John Wiley & Sons, Inc.; 1983:363-380.
27. 27. McCarty CA, Garrett SKM, Aldred GF, Taylor HR, for the Melbourne Excimer Laser Group. Assessment of subjective pain following photorefractive keratectomy. J Refractive Surg. 1996;12:365-369.
28. 28. Fowler CJ, Janson U, Johnson RM, et al. Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac and flurbiprofen. Arch Biochem Biophys. 1999;362:191-196.
29. 29. Levrat F, Pisella PJ, Badouin C. Clinical tolerance of antiglaucoma eyedrops with and without a preservative. Results of an unpublished survey in Europe. J Fr Ophtalmol. 1999:22:186-191.
30. 30. Berdy GJ, Abelson MB, Smith LM, George MA. Preservative-free artificial tear preparations. Assessment of corneal epithelial toxic effects. Arch Ophthalmol. 1992;110:528-532.
31. 31. Bequet F, Goldschild M, Moldovan MS, et al. Histopathological effects of topical ophthalmic preservatives on rat corneo-conjunctival surface. Curr Eye Res. 1998;17:419-425.
32. 32. Kaiser PK, Pineda R. A study of topical nonsteroidal anti-inflammatory drops and no pressure patching in the treatment of corneal abrasions. Corneal Abrasion Patching Study Group. Ophthalmology. 1997;104:1353-1359.
33. 33. Tutton MK, Cherry PMH, Sunder Raj P, Fsadni MG. Efficacy and safety of topical diclofenac in reducing ocular pain after excimer photorefractive keratectomy. J Cataract Refractive Surg. 1996;22: 536-541.