Acceleration of K+ channel inactivation by MEK inhibitor U0126

American Journal of Physiology - Cell Physiology

Volumn 290, Issue 1, 2006, Pages

  Yuan, Li Lian ^a,b   Chen, Xixi ^a   Kunjilwar, Kumud ^a   Pfaffinger, Paul ^a   Johnston, Daniel ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Gating; Kinase; Voltage gated potassium channel

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALANINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; VOLTAGE GATED POTASSIUM CHANNEL; 1,3 BUTADIENE DERIVATIVE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NITRILE; POTASSIUM; PROTEIN SUBUNIT; SHAL POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; DRUG EFFECT; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; ANIMAL; CHO CELL; DOSE RESPONSE; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; BUTADIENES; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ION CHANNEL GATING; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; NITRILES; POTASSIUM; PROTEIN SUBUNITS; RATS; SHAL POTASSIUM CHANNELS; TRANSFECTION;

EID: 33644818492     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00206.2005     Document Type: Article

References (25)

1. Adams JP, Anderson AE, Varga AW, Dineley KT, Cook RG, Pfaffinger PJ, and Sweatt JD. The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK. J Neurochem 75: 2277-2287, 2000.
2. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, and Rhodes KJ. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403: 553-556, 2000.
3. Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, and Sweatt JD. Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem 275: 5337-5346, 2000.
4. Bähring R, Boland LM, Varghese A, Gebauer M, and Pongs O. Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels. J Physiol 535: 65-81, 2001.
5. Birnbaum SG, Varga AW, Yuan LL, Anderson AE, Sweatt JD, and Schrader LA. Structure and function of Kv4-family transient potassium channels. Physiol Rev 84: 803-833, 2004.
6. Choi BH, Choi JS, Rhie DJ, Yoon SH, Min DS, Jo YH, Kim MS, and Hahn SJ. Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor. Am J Physiol Cell Physiol 282: C1461-C1468, 2002.
7. Dudley DT, Pang L, Decker SJ, Bridges AJ, and Saltiel AR. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92: 7686-7689, 1995.
8. English JD and Sweatt JD. Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J Biol Chem 271: 24329-24332, 1996.
9. English JD and Sweatt JD. A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation. J Biol Chem 272: 19103-19106, 1997.
10. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, and Trzaskos JM. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632, 1998.
11. Hartzell HC and Rinderknecht A. Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels. Am J Physiol Cell Physiol 270: C1293-C1299, 1996.
12. + channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J Neurosci 18: 3521-3528, 1998.
13. Hu HJ and Gereau RW IV. ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. II. Modulation of neuronal excitability. J Neurophysiol 90: 1680-1688, 2003.
14. + currents. J Neurophysiol 90: 1671-1679, 2003.
15. Lo CF and Breitwieser GE. Protein kinase-independent inhibition of muscarinic K+ channels by staurosporine. Am J Physiol Cell Physiol 266: C1128-C1132, 1994.
16. + channel polypeptides in rat hippocampal neurons developing in situ and in vitro. J Neurosci 15: 3840-3851, 1995.
17. Martin KC, Michael D, Rose JC, Barad M, Casadio A, Zhu H, and Kandel ER. MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia. Neuron 18: 899-912, 1997.
18. + channels by membrane lipids. Science 304: 265-270, 2004.
19. + current modulated by arachidonic acid regulates synaptic integration and threshold for LTP induction in hippocampal pyramidal cells. Proc Natl Acad Sci USA 99: 10144-10149, 2002.
20. + channel proteins in rat central neurons. Neuron 9: 271-284, 1992.
21. Varga AW, Yuan LL, Anderson AE, Schrader LA, Wu GY, Gatchel JR, Johnston D, and Sweatt JD. Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. J Neurosci 24: 3643-3654, 2004.
22. Watabe AM, Zaki PA, and O'Dell TJ. Coactivation of β-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase in the hippocampal CA1 region. J Neurosci 20: 5924-5931, 2000.
23. + channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proc Natl Acad Sci USA 99: 8366-8371, 2002.
24. Winder DG, Martin KC, Muzzio IA, Rohrer D, Chruscinski A, Kobilka B, and Kandel ER. ERK plays a regulatory role in induction of LTP by θ frequency stimulation and its modulation by β-adrenergic receptors. Neuron 24: 715-726, 1999.
25. + channels in hippocampus involves a mitogen-activated protein kinase pathway. J Neurosci 22: 4860-4868, 2002.