Transforming growth factor-β1 induces trans differentiation of fibroblasts into myofibroblasts in hypoxic pulmonary vascular remodeling

Acta Biochimica et Biophysica Sinica

Volumn 38, Issue 1, 2006, Pages 29-36

  Jiang, Yong Liang ^a   Dai, Ai Guo ^a   Li, Qi Fang ^a   Hu, Rui Cheng ^a  

^a Hunan Province Geriatric Hospital   (China)

Author keywords

Fibroblast; Hypertension; Lung; Myofibroblast; Transforming growth factor 1

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ANOXIA; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; FIBROBLAST; MALE; METABOLISM; MYOBLAST; PATHOLOGY; PULMONARY ARTERY; RAT; WISTAR RAT;

ANIMALS; ANOXIA; CELL DIFFERENTIATION; CELLS, CULTURED; FIBROBLASTS; MALE; MYOBLASTS, SMOOTH MUSCLE; PULMONARY ARTERY; RATS; RATS, WISTAR; TRANSFORMING GROWTH FACTOR BETA;

EID: 33644817439     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2006.00123.x     Document Type: Article

References (22)

1. Tomasek JJ Gabbiani G Hinz B Chaponnier C Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling Nat Rev Mol Cell Biol 2002 3 349 363
2. Walker GA Guerrero IA Leinwand LA. Myofibroblasts: Molecular crossdressers Curr Top Dev Biol 2001 51 91 107
3. Powell DW Mifflin RC Valentich JD Crowe SE Saada JI West AB. Myofibroblasts. I. Paracrine cells important in health and disease Am J Physiol Cell Physiol 1999 277 1 19
4. Serini G Gabbiani G. Mechanisms of myofibroblast activity and phenotypic modulation Exp Cell Res 1999 250 273 283
5. Rice NA Leinwand LA. Skeletal myosin heavy chain function in cultured lung myofibroblasts J Cell Biol 2003 163 119 129
6. Jarmuz T Roser S Rivera H Gal A Roman J. Transforming growth factor-beta 1, myofibroblasts, and tissue remodeling in the pathogenesis of tracheal injury: Potential role of gastroesophageal reflux Ann Otol Rhinol Laryngol 2004 113 488 497
7. Lijnen P Petrov V. Transforming growth factor-beta 1-induced collagen production in cultures of cardiac fibroblasts is the result of the appearance of myofibroblasts Methods Find Exp Clin Pharmacol 2002 24 333 344
8. Burgess HA Daugherty LE Thatcher TH Lakatos HF Ray DM Redonnet M Phipps RP et al. PPARγ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production: Implications for therapy of lung fibrosis Am J Physiol Lung Cell Mol Physiol 2005 288 1146 1153
9. Hu RC Dai AG Tan SX. Hypoxia-inducible factor 1 alpha upregulates the expression of inducible nitric oxide synthase gene in pulmonary arteries of hypoxic rat Chin Med J 2002 115 1833 1837
10. Li QF Dai AG. Hypoxia inducible factor-1 alpha correlates the expression of heme oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension Acta Biochim Biophys Sin 2004 36 133 140
11. Jeffery TK Wanstall JC. Pulmonary vascular remodeling: A target for therapeutic intervention in pulmonary hypertension Pharmacol Ther 2001 92 1 20
12. Thannickal VJ Lee DY White ES Cui Z Larios JM Chacon R Horowitz JC et al. Myofibroblast differentiation by transforming growth factor-β1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase J Biol Chem 2003 278 12384 12389
13. Arora PD McCulloch CA. The deletion of transforming growth factor-β-induced myofibroblasts depends on growth conditions and actin organization Am J Pathol 1999 155 2087 2099
14. Short M Nemenoff RA Zawada WM Stenmark KR Das M. Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts Am J Physiol Cell Physiol 2004 286 416 425
15. Reisdorf P Lawrence DA Sivan V Klising E Martin MT. Alteration of transforming growth factor-β1 response involves down-regulation of Smad3 signaling in myofibroblasts from skin fibrosis Am J Pathol 2001 159 263 272
16. Desmouliere A Chaponnier C Gabbiani G. Tissue repair, contraction, and the myofibroblast Wound Repair Regen 2005 13 7 12
17. Piek E Heldin CH Ten Dijke P. Specificity, diversity, and regulation in TGF-β superfamily signaling FASEB J 1999 13 2105 2124
18. 1 secretion from murine macrophages is released by in vivo ingestion of apoptotic cells Chest 2001 120 3
19. Fraser D Wakefield L Phillips A. Independent regulation of transforming growth factor-β1 transcription and translation by glucose and platelet-derived growth factor Am J Pathol 2002 161 1039 1049
20. Gao PJ Li Y Sun AJ Liu JJ Ji KD Zhang YZ Sun WL et al. Differentiation of vascular myofibroblasts induced by transforming growth factor-beta1 requires the involvement of protein kinase Calpha J Mol Cell Cardiol 2003 35 1105 1112
21. Petrov VV Fagard RH Lijnen PJ. Transforming growth factor-beta (1) induces angiotensin-converting enzyme synthesis in rat cardiac fibroblasts during their differentiation to myofibroblasts J Renin Angiotensin Aldosterone Syst 2000 1 342 352
22. 1 specifically induce proteins involved in the myofibroblast contractile apparatus Mol Cell Proteomics 2004 3 466 477