N-thiolated 2-oxazolidinones: A new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 8, 2006, Pages 2081-2083

  Mishra, Rajesh Kumar ^a   Revell, Kevin D ^a   Coates, Cristina M ^a   Turos, Edward ^a   Dickey, Sonja ^a   Lim, Daniel V ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Bacillus anthracis; MRSA; N thiolated lactam; N thiolated 2 oxazolidinones

Indexed keywords

2 OXAZOLIDINONE DERIVATIVE; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; STEREOCHEMISTRY;

ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; BETA-LACTAMS; DRUG RESISTANCE, MICROBIAL; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; OXAZOLIDINONES; STAPHYLOCOCCUS AUREUS; SULFHYDRYL COMPOUNDS;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 33644812336     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.058     Document Type: Article

References (19)

1. X.-F. Ren, M.I. Konaklieva, and E. Turos J. Org. Chem. 60 1995 4980
2. X.-F. Ren, M.I. Konaklieva, H. Shi, S. Dickey, D.V. Lim, J. Gonzalez, and E. Turos J. Org. Chem. 63 1998 8898
3. E. Turos, M.I. Konaklieva, R.X. Ren, H. Shi, J. Gonzalez, S. Dickey, and D.V. Lim Tetrahedron 56 2000 5571
4. E. Turos, T.E. Long, M.I. Konaklieva, C. Coates, J.-Y. Shim, S. Dickey, D.V. Lim, and A. Cannons Bioorg. Med. Chem. Lett. 12 2002 2229
5. C. Coates, T.E. Long, E. Turos, S. Dickey, and D.V. Lim Bioorg. Med. Chem. 11 2003 193
6. E. Long, E. Turos, M.I. Konaklieva, A.L. Blum, A. Amry, E.A. Baker, L.S. Suwandi, M.D. McCain, M.F. Rahman, S. Dickey, and D.V. Lim Bioorg. Med. Chem. 11 2003 1859
7. A. Kazi, R. Hill, T.E. Long, D. Kuhn, E. Turos, and Q.P. Dou Biochem. Pharmacol. 67 2004 365
8. Turos, E.; Long, T. E.; Heldreth, B.; Leslie, M.; Reddy, G. S. K.; Wang, Y.; Coates, C.; Konaklieva, M. I.; Dickey, S.; Lim, D. V.; Alonso, E.; Gonzalez, J. Bioorg. Med. Chem. Lett. 2006 (in press).
9. Chemistry and Biology of β-Lactam Antibiotics; Morin, R. B., Gorman, M.; Eds.; Academic Press: New York, 1982; Vols 1-3.
10. E. Turos, C. Coates, J.-Y. Shim, Y. Wang, J.M. Leslie, T.E. Long, G.S.K. Reddy, A. Ortiz, M. Culbreath, S. Dickey, D.V. Lim, E. Alonso, and J. Gonzalez Bioorg. Med. Chem. 13 2005 6289
11. S. Brickner J. Curr. Pharm. Des. 2 1996 175
12. O.A. Phillips Curr. Opin. Invest. Drugs 4 2003 117
13. S.J. Brickner, D.K. Hutchinson, M.R. Barbachyn, P.R. Manninen, D.A. Ulanowicz, S.A. Garmon, K.C. Grega, S.K. Hendges, D.S. Toops, C.W. Ford, and G.E. Zurenko J. Med. Chem. 39 1996 673
14. S.R. Woulfe, H. Iwagami, and M.J. Miller Tetrahedron Lett. 26 1985 3891
15. NCCLS (National Committee for Clinical Laboratory Standards) Methods for Dilution of Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically. NCCLS Document M7-A4, Vol. 17, No. 2, 1997.
16. Lactam 5 was prepared and tested as a racemic mixture of two diastereomers (1:1 ratio).
17. Heldreth, B.; Long, T. E.; Jang, S.; Reddy, G. S. K.; Turos, E.; Dickey, S.; Lim, D. V. Bioorg. Med. Chem. 2006 (in press).
18. H. Smith, and J. Keppie Nature 173 1954 869
19. A.M. Friedlander Nature 414 2001 160