Rhythmic neuronal discharge in the medulla and spinal cord of fetal rats in the absence of synaptic transmission

Journal of Neurophysiology

Volumn 95, Issue 1, 2006, Pages 527-534

  Ren, Jun ^a   Momose Sato, Yoko ^b   Sato, Katsushige ^b   Greer, John J ^a,c  

^a Centre for Neuroscience   (Canada)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; BICUCULLINE; CALCIUM; CARBENOXOLONE; DIZOCILPINE; DYE; NEUROTRANSMITTER RECEPTOR; RILUZOLE; STEARIC ACID DERIVATIVE; STRYCHNINE; SURAMIN; TURBOCURARINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTROPHYSIOLOGY; EPHAPSE; FETUS; GAP JUNCTION; HYPOGLOSSAL NERVE; IMAGING SYSTEM; IN VITRO STUDY; ION CONDUCTANCE; ION CURRENT; MEDULLA OBLONGATA; NERVE CELL MEMBRANE POTENTIAL; NEUROIMAGING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CONDUCTANCE; SPINAL CORD; SYNAPTIC TRANSMISSION; VENTRAL ROOT; WHOLE CELL; ACTION POTENTIAL; ANIMAL; BIOLOGICAL RHYTHM; NERVE CELL; PHYSIOLOGY; PRENATAL DEVELOPMENT; SPRAGUE DAWLEY RAT;

ACTION POTENTIALS; ANIMALS; BIOLOGICAL CLOCKS; MEDULLA OBLONGATA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 33644810389     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00735.2005     Document Type: Article

References (49)

1. Ba F, Ren J, and Greer JJ. Brain-derived neurotrophic factor release with neuronal activity in fetal rats. Neuroreport 16: 141-143, 2005.
2. Bikson M, Ghai RS, Baraban SC, and Durand DM. Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity. J Neurophysiol 82: 2262-2270, 1999.
3. Bittman KS, Panzer JA, and Balice-Gordon RJ. Patterns of cell-cell coupling in embryonic spinal cord studied via ballistic delivery of gap-junction-permeable dyes. J Comp Neurol 477: 273-285, 2004.
4. Butera RJ Jr, Rinzel J, and Smith JC. Models of respiratory rhythm generation in the pre-Botzinger complex. I. Bursting pacemaker neurons. J Neurophysiol 82: 382-397, 1999.
5. Chub N and O'Donovan MJ. Blockade and recovery of spontaneous rhythmic activity after application of neurotransmitter antagonists to spinal networks of the chick embryo. J Neurophysiol 85: 2166-2176, 1998.
6. Cohen JE and Fields RD. Extracellular calcium depletion in synaptic transmission. Neuroscientist 10: 12-17, 2004.
7. Dahm LM and Landmesser LT. The regulation of synaptogenesis during normal development and following activity blockade. J Neurosci 1: 238-255, 1991.
8. Darbon P, Yvon C, Legrand JC, and Streit J. INaP underlies intrinsic spiking and rhythm generation in networks of cultured rat spinal cord neurons. Eur J Neurosci 20: 976-988, 2004.
9. Dudek FE, Yasumura T, and Rash JE. "Non-synaptic " mechanisms in seizures and epileptogenesis. Cell Biol Int 22: 793-805, 1998.
10. + conductance in neurons of the gastric mill rhythm generator of spiny lobsters. J Exp Biol 200: 1795-1807, 1997.
11. Frankenhaeuser B and Hodgkin A. The action of calcium on the electrical properties of squid axons. J Physiol 137: 218-244, 1957.
12. Greer JJ, Smith JC, and Feldman JL. Respiratory and locomotor patterns generated in the fetal rat brain stem-spinal cord in vitro. J Neurophysiol 67: 996-999, 1992.
13. Haas HL and Jefferys JG. Low-calcium field burst discharges of CA1 pyramidal neurones in rat hippocampal slices. J Physiol 354: 185-201, 1984.
14. Hanson MG and Landmesser LT. Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic mouse spinal cord. J Neurosci 23: 587-600, 2003.
15. Hanson MG and Landmesser LT. Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules. Neuron 43: 687-701, 2004.
16. Hofer AM. Another dimension to calcium signaling: a look at extracellular calcium. J Cell Sci 118: 855-862, 2005.
17. Jefferys JG. Nonsynaptic modulation of neuronal activity in the brain: electric currents and extracellular ions. Physiol Rev 75: 689-723, 1995.
18. Jefferys JGR and Haas HL. Synchronized bursting of CA1 pyramidal cells in the absence of synaptic transmission. Nature 300: 448-450, 1982.
19. Katz LC and Shatz CJ. Synaptic activity and the construction of cortical circuits. Science 274: 1133-1138, 1996.
20. Kiehn O and Tresch MC. Gap junctions and motor behavior. Trends Neurosci 25: 108-115, 2002.
21. Kobayashi K, Lemke RP, and Greer JJ. Development of fetal breathing movements in the rat. J Appl Physiol 91: 316-320, 2001.
22. Kofuji P and Newman EA. Potassium buffering in the central nervous system. Neuroscience 129: 1043-1054, 2004.
23. Konnerth A, Heinemann U, and Yaari Y. Slow transmission of neural activity in hippocampal area CA1 in absence of active chemical synapses. Nature 307: 69-71, 1984.
24. Lian J, Bikson M, Shuai J, and Durand DM. Propagation of non-synaptic epileptiform activity across a lesion in rat hippocampal slices. J Physiol 537: 191-199, 2001.
25. Martin-Caraballo M and Greer JJ. Electrophysiological properties of rat phrenic motoneurons during the perinatal development. J Neurophysiol 81: 1365-1378, 1999.
26. McCobb DP, Best PM, and Beam KG. The differentiation of excitability on embryonic chick limb motoneurons. J Neurosci 10: 2974-2984, 1990.
27. Milner LD and Landmesser LT. Cholinergic and GABAergic inputs drive patterned spontaneous motoneuron activity before target contact. J Neurosci 19: 3007-3022, 1999.
28. Momose-Sato Y, Sato K, and Kamino K. Optical approaches to embryonic development of neural functions in the brainstem. Prog Neurobiol 63: 151-197, 2001.
29. Momose-Sato Y, Sato K, Sakai T, Hirota A, Matsutani K, and Kamino K. Evaluation of optimal voltage-sensitive dyes for optical monitoring of embryonic neural activity. J Membr Biol 144: 167-176, 1995.
30. Nakayama K, Nishimaru H, Iizuka M, Ozaki S, and Kudo N. Rostrocaudal progression in the development of periodic spontaneous activity in fetal rat spinal motor circuits in vitro. J Neurophysiol 81: 2592-2595, 1999.
31. Nishimaru H, Iizuka M, Ozaki S, and Kudo N. Spontaneous motoneuronal activity mediated by glycine and GABA in the spinal cord of rat fetuses in vitro. J Physiol 497: 131-143, 1996.
32. O'Donovan MJ. The origin of spontaneous activity in developing networks of the vertebrate nervous system. Curr Opin Neurobiol 9: 94-104, 1999.
33. Ren J and Greer JJ. Ontogeny of rhythmic motor patterns generated in the embryonic rat spinal cord. J Neurophysiol 89: 1187-1195, 2003.
34. A receptor-mediated responses in spinal neurons. J Neuroscience 16: 82-91, 1996.
35. Sato K, Momose-Sato Y, Arai Y, Hirota A, and Kamino K. Optical illustration of glutamate-induced cell swelling coupled with membrane depolarization in embryonic brain stem slices. Neuroreport 8: 3559-3563, 1997.
36. 2+-free solution. Biophys J 3: 2099-2111, 2003.
37. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, and Feldman JL. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254: 726-729, 1991.
38. Spitzer NC and Ribera AB. Development of electrical excitability in embryonic neurons: mechanisms and roles. J Neurobiol 37: 190-197, 1998.
39. Stringer JL. Regulation of extracellular potassium in the developing hippocampus. Brain Res Dev Brain Res 110: 97-103, 1998.
40. Su H, Alroy G, Kirson ED, and Yaari Y. Extracellular calcium modulates persistent sodium current-dependent burst-firing in hippocampal pyramidal neurons. J Neurosci 21: 4173-4182, 2001.
41. +, pH, and volume changes in spinal cord of adult rats and during postnatal development. Can J Physiol Pharmacol Suppl 70: S301-S309, 1992.
42. Tresch MC and Kiehn O. Motor coordination without action potentials in the mammalian spinal cord. Nat Neurosci 3: 593-599, 2000.
43. Viana F, Bayliss DA, and Berger A.J. Calcium conductances and their role in the firing behavior of neonatal rat hypoglossal motoneurons. J Neurophysiol 69: 2137-2149, 1993.
44. Walton KD and Navarrete R. Postnatal changes in motoneuron electrotonic coupling studies in the in vitro rat lumbar spinal cord. J Physiol 43: 283-305, 1991.
45. Wu WL, Ziskind-Conhaim L, and Sweet MA. Early development of glycine- and GABA-mediated synapses in rat spinal cord. J Neurosci 12: 3935-3945, 1992.
46. 2+ dependent synaptic release delays motoneuron differentiation in the rat spinal cord. J Neurosci 15: 5900-5911, 1995.
47. Yvert B, Branchereau P, and Meyrand P. Multiple spontaneous rhythmic activity patterns generated by the embryonic mouse spinal cord occur within a specific developmental time window. J Neurophysiol 91: 2101-2109, 2004.
48. Ziskind-Conhaim L. Electrical properties of motoneurons in the spinal cord of the rat embryo. Dev Biol 128: 21-29, 1988.
49. Ziskind-Conhaim L. Physiological functions of GABA-induced depolarizations in the developing rat spinal cord. Perspect Dev Neurobiol 5: 279-287, 1998.