A synergistic effect between PG490-88 and tacrolimus prolongs renal allograft survival in monkeys

American Journal of Transplantation

Volumn 6, Issue 4, 2006, Pages 714-723

  Chen, G ^a   Sun, H ^a   Arp, J ^a   Garcia, B ^a   Wang, X ^a   Wise, Y ^a   Liu, W ^a   Ramcharran, S ^a   Huang, X ^a   Xiang, Y ^a   Yang, H ^a   Fang, Z ^a   Madenas, J ^a,b   Sudo, Y ^c   Tamura, K ^c   Zhong, R ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c ASTELLAS PHARMA INC   (Japan)

Author keywords

Immunosuppression; Kidney; Monkey; PG490 88; Tacrolimus; Transplantation

Indexed keywords

CD3 ANTIBODY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; INTERLEUKIN 2; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR NFAT; TRIPTOLIDE; TRIPTOLIDE SUCCINATE; TSUKUBAENOLIDE; UNCLASSIFIED DRUG; GAMMA INTERFERON; OMTRIPTOLIDE; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENTIATION; DRUG TOLERABILITY; GRAFT SURVIVAL; IMMUNOGLOBULIN PRODUCTION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; LOW DRUG DOSE; LYMPHOCYTIC INFILTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MONKEY; MONOTHERAPY; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; SURVIVAL TIME; T LYMPHOCYTE; UREMIA; GRAFT RECIPIENT; IC50; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; LYMPHOCYTE PROLIFERATION; MACACA FASCICULARIS;

ANIMALS; CELL PROLIFERATION; DITERPENES; DRUG SYNERGISM; GRAFT REJECTION; GRAFT SURVIVAL; HAPLORHINI; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-2; KIDNEY TRANSPLANTATION; MALE; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; T-LYMPHOCYTES; TACROLIMUS; TRANS-ACTIVATION (GENETICS);

EID: 33644776853     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01257.x     Document Type: Article

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