An isotonic preparation of 1 mg/ml indocyanine green is not toxic to hyperconfluent ARPE19 cells, even after prolonged exposure

Acta Ophthalmologica Scandinavica

Volumn 84, Issue 1, 2006, Pages 42-46

  Kiilgaard, Jens Folke ^a,b   Nissen, Mogens Holst ^a   la Cour, Morten ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

ARPE19 cells; Indocyanine green; Infracyanine green; Inner limiting membrane (ILM) peeling; Macular hole; Retinal pigment epithelium; Surgery; Toxicity

Indexed keywords

INDOCYANINE GREEN; ISOTONIC SOLUTION;

ARTICLE; CELL CULTURE; CELL DEATH; CELL GROWTH; CELL MATURATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY TEST; HUMAN; HUMAN CELL; IN VITRO STUDY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

CELL LINE; CELL SURVIVAL; COLORING AGENTS; HUMANS; INDOCYANINE GREEN; ISOTONIC SOLUTIONS; PIGMENT EPITHELIUM OF EYE; RETINAL PERFORATIONS; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS;

EID: 33644762999     PISSN: 13953907     EISSN: 16000420     Source Type: Journal    
DOI: 10.1111/j.1600-0420.2005.00593.x     Document Type: Article

References (28)

1. Ando F, Sasano K, Suzuki F & Ohba N (2004): Indocyanine green-assisted ILM peeling in macular hole surgery revisited. Am J Ophthalmol 138: 886-887.
2. Bailey TA, Kanuga N, Romero IA, Greenwood J, Luthert PJ & Cheetham ME (2004): Oxidative stress affects the junctional integrity of retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 45: 675-684.
3. Brooks HL Jr (2000): Macular hole surgery with and without internal limiting membrane peeling. Ophthalmology 107: 1939-1948.
4. Da Mata AP, Burk SE, Foster RE, Riemann CD, Petersen MR, Nehemy MB & Augsburger JJ (2004): Longterm follow-up of indocyanine green-assisted peeling of the retinal internal limiting membrane during vitrectomy surgery for idiopathic macular hole repair. Ophthalmology 111: 2246-2253.
5. Da Mata AP, Burk SE, Riemann CD, Rosa RH, Snyder ME, Petersen MR & Foster RE (2001): Indocyanine green-assisted peeling of the retinal internal limiting membrane during vitrectomy surgery for macular hole repair. Ophthalmology 108: 1187-1192.
6. Gale JS, Proulx AA, Gonder JR, Mao AJ & Hutnik CM (2004): Comparison of the in vitro toxicity of indocyanine green to that of trypan blue in human retinal pigment epithelium cell cultures. Am J Ophthalmol 138: 64-69.
7. Gass CA, Haritoglou C, Schaumberger M & Kampik A (2003): Functional outcome of macular hole surgery with and without indocyanine green-assisted peeling of the internal limiting membrane. Graefes Arch Clin Exp Ophthalmol 241: 716-720.
8. Haritoglou C, Gandorfer A, Gass CA, Schaumberger M, Ulbig MW & Kampik A (2003): The effect of indocyanine-green on functional outcome of macular pucker surgery. Am J Ophthalmol 135: 328-337.
9. Hillenkamp J, Saikia P, Gora F, Sachs HG, Lohmann CP, Roider J, Baumler W & Gabel VP (2005): Macular function and morphology after peeling of idiopathic epiretinal membrane with and without the assistance of indocyanine green. Br J Ophthalmol 89: 437-443.
10. Ho JD, Tsai RJ, Chen SN & Chen HC (2003): Toxic effect of indocyanine green on retinal pigment epithelium related to osmotic effects of the solvent. Am J Ophthalmol 135: 258.
11. Horio N & Horiguchi M (2004): Effect on visual outcome after macular hole surgery when staining the internal limiting membrane with indocyanine green dye. Arch Ophthalmol 122: 992-996.
12. Iriyama A, Uchida S, Yanagi Y, Tamaki Y, Inoue Y, Matsuura K, Kadonosono K & Araie M (2004): Effects of indocyanine green on retinal ganglion cells. Invest Ophthalmol Vis Sci 45: 943-947.
13. Jackson TL (2005): Indocyanine green accused. Br J Ophthalmol 89: 395-396.
14. Jackson TL, Hillenkamp J, Knight BC, Zhang JJ, Thomas D, Stanford MR & Marshall J (2004a): Safety testing of indocyanine green and trypan blue using retinal pigment epithelium and glial cell cultures. Invest Ophthalmol Vis Sci 45: 2778-2785.
15. Jackson TL, Vote B, Knight BC, El Amir A, Stanford MR & Marshall J (2004b): Safety testing of infracyanine green using retinal pigment epithelium and glial cell cultures. Invest Ophthalmol Vis Sci 45: 3697-3703.
16. Jaycock PD, Bunce CX, Ing W, Thomas D, Poon W, Gazzard G & Williamson TH (2005): OutcomIs of macular hole surgery: implications for surgical management and clinical goverance. Eye 19: 879-884.
17. Jorgensen A, Junker N, Kaestel CG et al. (2005): Superantigen presentation by human retinal pigment epithelial cells to T cells is dependent on CD2-CD58 and CD18-CD54 molecule interactions. Exp Eye Res 73: 723-733.
18. Kaestel CG, Jorgensen A, Nielsen M, Eriksen KW, Odum N, Holst NM & Ropke C (2002): Human retinal pigment epithelial cells inhibit proliferation and IL2R expression of activated T cells. Exp Eye Res 74: 627-637.
19. Kaestel CG, Madsen HO, Prause JU et al. (2001): Lack of FasL expression in cultured human retinal pigment epithelial cells. Exp Clin Immunogenet 18: 34-41.
20. Kwok AK, Lai TY, Yuen KS, Tam BS & Wong VW (2003): Macular hole surgery with or without indocyanine green-stained internal limiting membrane peeling. Clin Exp Ophthalmol 31: 470-475.
21. Kwok AK, Li WW, Pang CP, Lai TY, Yam GH, Chan NR & Lam DS (2001): Indocyanine green staining and removal of internal limiting membrane in macular hole surgery: Histology and outcome. Am J Ophthalmol 132: 178-183.
22. Murata M, Shimizu S, Horiuchi S & Sato S (2005): The effect of indocyanine green on cultured retinal glial cells. Retina 25: 75-80.
23. Nicolini J, Kiilgaard JF, Wiencke AK, Heegaard S, Scherfig E, Prause JU & la Cour M (2000): The anterior lens capsule used as support material in RPE cell transplantation. [In Process Citation]. Acta Ophthalmol Scand 78: 527-531.
24. Rezai KA, Farrokh-Siar L, Ernest JT & van Seventer GA (2004): Indocyanine green induces apoptosis in human retinal pigment epithelial cells. Am J Ophthalmol 137: 931-933.
25. Sippy BD, Engelbrecht NE, Hubbard GB et al. (2001): Indocyanine green effect on cultured human retinal pigment epithelial cells: Implication for macular hole surgery. Am J Ophthalmol 132: 433-435.
26. Stalmans P, Parys-Vanginderdeuren R, De Vos R & Feron EJ (2001): ICG staining of the inner limiting membrane facilitates its removal during surgery for macular holes and puckers. Bull Soc Belge Ophtalmol 281: 21-26.
27. Stalmans P, Van Aken EH, Veckeneer M, Feron EJ & Stalmans I (2002): Toxic effect of indocyanine green on retinal pigment epithelium related to osmotic effects of the solvent. Am J Ophthalmol 134: 282-285.
28. Weinberger AW, Kirchhof B, Mazinani BE & Schrage NF (2001): Persistent indocyanine green (ICG) fluorescence 6 weeks after intraocular ICG administration for macular hole surgery. Graefes Arch Clin Exp Ophthalmol 239: 388-390.