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33644780363
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note
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As an indicatior of the relative activity of D versus 3-substituted-4-aminopyridines, the former are generally used at 0 °C to catalyze alcohol acylation, whereas the latter may be employed at -78 °C.
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22
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26
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33644754459
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note
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2-symmetric 2,5-disubstituted pyrrolidines; see ref 6c.
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-
-
-
27
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33644748806
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note
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2)] R1 = 0.0385, wR2 = 0.0880 and for all data R1 = 0.0605, wR2 = 0.0971.
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-
-
-
28
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33644764426
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note
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pR (5.14 ppm) enhancement ratio of > 23:1 (the latter was not observed).
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-
-
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29
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0035911983
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An alternative way to consider the stereochemical environment of the pyridine moiety is to regard it as being in an environment of virtual planar chirality. See: Jones, G.; Richards, C. J. Organometallics 2001, 20, 1251.
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84982075848
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(c) Höfle, G.; Prox, A.; Steglich, W. Chem. Ber. 1972, 105, 1718.
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35
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This has previously been successfully applied to the related rearrangement of O-acylated oxindoles, see: Hills, I. D.; Fu, G. C. Angew. Chem., Int. Ed. 2003, 42, 3921.
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