Investigating widely available substances as vaginal microbicides

Sexual Health

Volumn 1, Issue 2, 2004, Pages 73-79

  Holmes, Wendy ^a  

^a MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; PLANT MEDICINAL PRODUCT; TOPICAL ANTIINFECTIVE AGENT;

CARBONATED BEVERAGE; CITRUS FRUIT; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVAGINAL DRUG ADMINISTRATION; METHODOLOGY; MUCOSA; PATHOGENICITY; PHYTOTHERAPY; REVIEW; SAFE SEX; TREATMENT OUTCOME; VAGINAL LAVAGE; VIROLOGY;

ACETIC ACID; ADMINISTRATION, INTRAVAGINAL; ANTI-INFECTIVE AGENTS, LOCAL; CARBONATED BEVERAGES; CITRUS; DRUG EVALUATION; FEMALE; HIV; HIV INFECTIONS; HUMANS; MUCOUS MEMBRANE; PHYTOTHERAPY; PLANT PREPARATIONS; SAFE SEX; TREATMENT OUTCOME; VAGINAL DOUCHING;

EID: 33644698137     PISSN: 14485028     EISSN: None     Source Type: Journal    
DOI: 10.1071/SH04013     Document Type: Article

References (58)

1. McCormack S. Vaginal microbicides. Curr Opin Infect Dis 2002; 15(1): 57-62.
2. Alliance for Microbicide Development. Available online at: http://www.microbicide.org/ (accessed 6 May 2004).
3. Lard-Whiteford SL, Matecka D, O'Rear J, Yuen I, Litterst C, Reichelderfer P. Recommendations for the nonclinical development of topical microbicides for prevention of HIV transmission: An update. J Acquir Immune Defic Syndr 2004; 36(1): 541-52.
4. Mauck C, Rosenberg Z, Van Damme L. Recommendations for the clinical development of topical microbicides: an update. AIDS 2001; 15: 857-68. doi: 10.1097/00002030-200105040-00006
5. Paavonen J. Physiology and ecology of the vagina. Scand J Infect Dis Suppl 1983; 40: 31-5.
6. Martin HL, Jr, Richardson BA, Nyange PM, Lavreys L, Hillier SL, Chohan B, et al. Vaginal lactobacilli, microbial flora, and risk of Human Immunodeficiency Virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180(6): 1863-8. doi: 10.1086/315127
7. Hillier SL. The vaginal microbial ecosystem and resistance to HIV AIDS Res Hum Retroviruses 1998; 14: S17-21.
8. Klebanoff SL, Coombs RW. Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission. J Exp Med 1991; 174: 289-92.
9. Gray RH, Wawer MJ, Brookmeyer R, Sewankambo NK, Serwadda D, Wabwire-Mangen F, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001; 357: 1149-53. doi: 10.1016/S0140-6736(00)04331-2
10. Pope M, Haase A. Transmission, acute HIV-1 infection and the quest for strategies to prevent infection. Nat Med 2003; 9(7): 847-52. doi: 10.1038/NM0703-847
11. Hu J, Gardner MB, Miller CJ. Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells. J Virol 2000; 74(13): 6087-95. doi: 10.1128/JVI.74.13.6087-6095.2000
12. Martin LS, McDougal JS, Loskoski SL. Disinfection and inactivation of the human lymphotropic virus type III/lymphadenopathy-associated virus. J Infect Dis 1985; 152: 400-3.
13. Foster IM, Bartlett J. Anti-HIV substances for rape victims. JAMA 1989; 261: 3407B. doi: 10.1001/JAMA.261.23.3407B
14. Bartlett JG, Finkbeiner AK. The guide to living with HIV infection. Developed at John Hopkins AIDS Clinic. Baltimore: The John Hopkins University Press; 1993
15. Marotta T. AIDS-preventing sexual hygiene: complement condom use by gargling, douching, and washing after sex. Available online at: http://safest-sex.desert.net/safest-sex/index.html (verified 7 February 2004).
16. Oyelola OO, Ayangade SO, Amole F. In vitro inhibition of sperm motility by some local mineral water drinks. Contraception 1987; 36(4): 435-40. doi: 10.1016/0010-7824(87)90092-8
17. Summerhayes E. Tricks of the trade. Cervical Cap Ltd. Available online at: http://www.cervcap.com/tricks.html (verified 7 February 2004).
18. Lemons - a history. Available online at: http://www.aids.net.au/lemons-history.htm (accessed 30 April 2004).
19. Potts M, Short RV. Using microbicides to fight the spread of HIV. Science 2003; 300(5618): 431A. doi: 10.1126/SCIENCE.300.5618.431A
20. Potts M, Walsh J. Tackling India's HIV epidemic: lessons from Africa. BMJ 2003; 326: 1389-92. doi: 10.1136/BMJ. 326.7403.1389
21. Short R. Primate toxicity trial of intravaginal lime juice. 16 June, 2003. Available online at: http://www.aids.net.au/lemons-news-16-06-03.htm (accessed 30 April 2004).
22. Sant-Rayn Pasricha. Subject: Efficacy of lemons as microbicide: Invitation to Indian researchers/Institutions 14 July 2003. Available online at: http://groups.yahoo.com/group/AIDS-INDIA/message/2592 (verified 7 February 2004).
23. Overman BA. The vagina as an ecologic system. Current understanding and clinical applications. J Nurse Midwifery 1993; 38(3): 146-51.
24. Wright TC, Jr, Subbarao S, Ellerbrock TV, Lennox JL, Evans-Strickfaden T, Smith DG, et al. Human immunodeficiency virus 1 expression in the female genital tract in association with cervical inflammation and ulceration. Am J Obstet Gynecol 2001; 184(3): 279-85. doi: 10.1067/MOB.2001.108999
25. Van Damme L, Ramjee G, Alary M, Vuylsteke B, Chandeying V, Rees H, et al. COL-1492 Study Group. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet 2002; 360: 971-7. doi: 10.1016/80140-6736(02)11079-8
26. Fichorova RN, Tucker LD, Anderson DJ. The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J Infect Dis 2001; 184(4): 418-28. doi: 10.1086/322047
27. Kaminsky M, Willigan DA. pH and the potential irritancy of douche formulations to the vaginal mucosa of the albino rabbit and rat. Food Chem Toxicol 1982; 20(2): 193-6.
28. Short RV, McCoombe SG, Maslin CL, Crowe SM. Lemon and lime juice as potent natural microbicides. Available online at: http://www.aids.net.au/lemons-news12-02-04.htm (accessed 30 April 2004).
29. Wagner AM, Wu JJ, Hansen RC, Nigg HN, Beiere RC. Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. Am J Contact Dermal 2002; 13(1): 10-4. doi: 10.1053/AJCD.2002.29948
30. Taha TE, Hoover DR, Dallabetta GA, et al. Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV AIDS 1998; 12: 1699-706. doi: 10.1097/00002030-199813000-00019
31. Klebanoff SJ, Watts DH, Mehlin C, Headley CM. Lactobacilli and vaginal host defense: activation of the Human Immunodeficiency Virus Type 1 long terminal repeat, cytokine production, and NF-Kappa B. J Infect Dis 1999; 179(3): 653-60. doi: 10.1086/314644
32. Rosenstein IJ, Stafford MK, Kitchen VS, Ward H, Weber JN, Taylor-Robinson D. Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1. J Infect Dis 1998; 177(5): 1386-90.
33. Newton-John HF, Wise K, Looke DFM. Role of the lemon indisseminated candidiasis of heroin abusers. Med J Aust 1984; 140: 780-1.
34. Centre for Science and Environment. Delhi, India. Available online at: http://www.downtoearth.org.in/full6.asp?foldername= 20030815&filename=anal&sec_id=7&sid=1 (accessed 15 August 2003).
35. Hughes VL, Hillier SL. Microbiologic characteristics of Lactobacillus products used for colonization of the vagina. Obstet Gynecol 1990; 75(2): 244-8.
36. La Ruche G, Messou N, Ali-Napo L, et al. Vaginal douching: association with lower genital tract infections in African pregnant women. Sex Transm Dis 1999; 26(4): 191-6.
37. Fonck K, Kaul R, Keli F, Bwayo JJ, Ngugi EN, Moses S, et al. STIs and vaginal douching in a population of female sex workers in Nairobi, Kenya. Sex Transm Infect 2001; 77(4): 5.
38. Ministry issues warning over use of lime as contraceptive. Bangkok Post, Saturday 10 August, 2002.
39. Perlman D, Mandora M, Prata N, Campbell M, Potts M. Lime use and reproductive health in northern Nigeria: a feasibility study. Available online at: http://www.aids.net.au/lemons-news-02-03-04.htm (accessed 30 April 2004).
40. Elias CJ, Heise LL. Challenges for the development of female-controlled vaginal microbicides. AIDS 1994; 8(1): 1-9.
41. Mayer K, Karim S, Kelly C, Maslankowski L, Rees H, Profy A, et al. Safety and tolerability of vaginal PRO 2000 gel in sexually active HIV-uninfected and abstinent HIV-infected women. AIDS 2003; 17(3): 329.
42. Runganga A, Pitts M, McMaster J. The use of herbal and other agents to enhance sexual experience. Soc Sci Med 1992; 35(8): 1037-42. doi: 10.1016/0277-9536(92)90243-J
43. Hardy E, de Padua KS, Hebling EM, Osis MJ, Zaneveld LJ. Women's preferences for vaginal antimicrobial contraceptives. V: attitudes of Brazilian women to the insertion of vaginal products. Contraception 2003; 67(5): 391-5. doi: 10.1016/S0010-7824(03)00026-X
44. Lambert H. Methods and meanings in anthropological, epidemiological and clinical encounters: the case of sexually transmitted disease and human immunodeficiency virus control and prevention in India. Trop Med Int Health 1998; 3(12): 1002-10. doi: 10.1046/J.1365-3156.1998.00336.X
45. Lichtenstein B, Nansel TR. Women's douching practices and related attitudes: findings from four focus groups. Women Health 2000; 31(2-3): 117-31.
46. Moon MW, Khumalo-Sakutukwa GN, Heiman JE, Mbizvo MT, Padian NS. Vaginal microbicides for HIV/STI prevention in Zimbabwe: what key informants say. Transcult Nurs. 2002; 13(1): 19-23.
47. Coggins C, Blanchard K, Friedland B. Men's attitudes towards a potential vaginal microbicide in Zimbabwe, Mexico and the USA. Reprod Health Matters 2000; 8(15): 132-41. doi: 10.1016/80968-8080(00)90015-6
48. Heise L, McGrory E, Wood S. The practical and ethical dilemmas in the clinical testing of microbicides: a report on a symposium. International Women's Health Coalition, New York, 1998. Available online at: http://www.iwhc.org/micropub.html (verified 7 February 2004).
49. Elias C, Coggins C. Acceptability research on female-controlled barrier methods to prevent heterosexual transmission of HIV: Where have we been? Where are we going? J Womens Health Gend Based Med 2001; 10(2): 163-73. doi: 10.1089/152460901300039502
50. The Female Condom. A guide for planning and programming. WHO and UNAIDS, 2000. Available online at: www.unaids.org/publications/documents/care/index.html#female (verified 8 February 2004).
51. Gray S, Prybylski D, Merten M, Pillai S, Pandya S. Report Series: PSI Lubricant Social Marketing-Lessons Learned. Washington, DC, USA: Population Services International; 2002
52. World Health Organization. Recommendations for the development of vaginal microbicides. The International Working Group on Vaginal Microbicides. AIDS 1996; 10: 1-6.
53. Ettiegne-Traore V, Ghys PD, Van Damme L, N'Krumah M, Maiga A, Tiemele A. Acceptability and feasibility of a clinical trial to assess the efficacy of a microbicide-containing vaginal gel to prevent HIV infection among female sex workers in Abidjan, Cote d'Ivoire. AIDS 1997; 11(13): 1660-2.
54. Foss AM, Vickerman PT, Heise L, Watts CH. Shifts in condom use following microbicide introduction: should we be concerned? AIDS 2003; 17(8): 1227-37. doi: 10.1097/00002030-20030523000015
55. Reed BD, Ford K, Wirawan DN. The Bali STD/AIDS study: association between vaginal hygiene practices and STDs among sex workers. Sex Transm Infect 2001; 77(1): 46-52. doi: 10.1136/STI.77.1.46
56. Mobilisation for microbes - the decisive decade. The Microbicide Initiative, 2000. Available online at: http://www.rockfound.org (verified 7 February 2004).
57. Global Campaign for Microbicides. Lemon juice: no data on safety or effectiveness as a microbicide, October 25,2002. Available online at: http://www.global-campaign.org/gcnews.htm
58. International Partnership for Microbicides. Available online at: http://www.ipm-microbicides.org/ (accessed 7 February 2004).