Effects of 2 wk of GH administration on 24-h indirect calorimetry in young, healthy, lean men

American Journal of Physiology - Endocrinology and Metabolism

Volumn 289, Issue 6, 2005, Pages

  Hansen, Mette ^a   Morthorst, Rikke ^a   Larsson, Benny ^a   Flyvbjerg, Allan ^b   Rasmussen, Michael Højby ^b,c   Ørskov, Hans ^b   Astrup, Arne ^d   Kjaer, Michael ^a   Lange, Kai Henrik Wiborg ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c NOVO NORDISK A S   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Energy expenditure; Fat oxidation; Growth hormone; Insulin like growth factor i; Metabolism

Indexed keywords

FATTY ACID; GROWTH HORMONE; HUMAN GROWTH HORMONE; PLACEBO; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN C; DRUG DERIVATIVE; FLUORESCEIN DERIVATIVE; OUABAIN; RHODOL GREEN ETHYLENEDIAMINE OUABAIN; RHODOL GREEN-ETHYLENEDIAMINE-OUABAIN;

ABSENCE OF SIDE EFFECTS; ADULT; ANTHROPOMETRY; ARTICLE; CALORIMETRY; CONTROLLED STUDY; DRUG EFFECT; ENERGY BALANCE; ENERGY EXPENDITURE; HUMAN; HUMAN EXPERIMENT; LEAN BODY WEIGHT; MALE; METABOLIC PARAMETERS; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; RESPIRATORY QUOTIENT; BLOOD; BODY COMPOSITION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; ENERGY METABOLISM; RANDOMIZED CONTROLLED TRIAL; TIME;

ADULT; BODY COMPOSITION; CALORIMETRY, INDIRECT; DOUBLE-BLIND METHOD; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; FLUORESCEINS; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; OUABAIN; PLACEBOS; TIME FACTORS;

EID: 33644675964     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00124.2005     Document Type: Article

References (64)

1. Albert SG and Mooradian AD. Low-dose recombinant human growth hormone as adjuvant therapy to lifestyle modifications in the management of obesity. J Clin Endocrinol Metab 89: 695-701, 2004.
2. Astrup A, Buemann B, Christensen NJ, Madsen J, Gluud C, Bennett P, and Svenstrup B. The contribution of body composition, substrates, and hormones to the variability in energy expenditure and substrate utilization in premenopausal women. J Clin Endocrinol Metab 74: 279-286, 1992.
3. Astrup A, Thorbek G, Lind J, and Isaksson B. Prediction of 24-h energy expenditure and its components from physical characteristics and body composition in normal-weight humans. Am J Clin Nutr 52: 777-783, 1990.
4. Bak JF, Møller N, and Schmitz O. Effects of growth hormone on fuel utilization and muscle glycogen synthase activity in normal humans. Am J Physiol Endocrinol Metab 260: E736-E742, 1991.
5. Baumann G, Shaw MA, and Buchanan TA. In vivo kinetics of a covalent growth hormone-binding protein complex. Metabolism 38: 330-333, 1989.
6. Bengtsson BA, Brummer RJ, and Bosaeus I. Growth hormone and body composition. Horm Res 33, Suppl 4: 19-24, 1990.
7. Black AE, Bingham SA, Johansson G, and Coward WA. Validation of dietary intakes of protein and energy against 24 hour urinary N and DLW energy expenditure in middle-aged women, retired men and post-obese subjects: comparisons with validation against presumed energy requirements. Eur J Clin Nutr 51: 405-413, 1997.
8. Bramnert M, Segerlantz M, Laurila E, Daugaard JR, Manhem P, and Groop L. Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle. J Clin Endocrinol Metab 88: 1455-1463, 2003.
9. Buijs MM, Romijn JA, Burggraaf J, De Kam ML, Cohen AF, Frolich M, Stellaard F, Meinders AE, and Pijl H. Growth hormone blunts protein oxidation and promotes protein turnover to a similar extent in abdominally obese and normal-weight women. J Clin Endocrinol Metab 87: 5668-5674, 2002.
10. Butterfield GE, Thompson J, Rennie MJ, Marcus R, Hintz RL, and Hoffman AR. Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women. Am J Physiol Endocrinol Metab 272: E94-E99, 1997.
11. Carlson MG, Snead WL, Hill JO, Nurjhan N, and Campbell PJ. Glucose regulation of lipid metabolism in humans. Am J Physiol Endocrinol Metab 261: E815-E820, 1991.
12. Chong PK, Jung RT, Scrimgeour CM, Rennie MJ, and Paterson CR. Energy expenditure and body composition in growth hormone deficient adults on exogenous growth hormone. Clin Endocrinol (Oxf) 40: 103-110, 1994.
13. Copeland KC and Nair KS. Acute growth hormone effects on amino acid and lipid metabolism. J Clin Endocrinol Metab 78: 1040-1047, 1994.
14. Crist DM, Peake GT, Egan PA, and Waters DL. Body composition response to exogenous GH during training in highly conditioned adults. J Appl Physiol 65: 579-584, 1988.
15. Cummings DE and Merriam GR. Growth hormone therapy in adults. Annu Rev Med 54: 513-533, 2003.
16. Deyssig R, Frisch H, Blum WF, and Waldhor T. Effect of growth hormone treatment on hormonal parameters, body composition and strength in athletes. Acta Endocrinol 128: 313-318, 1993.
17. Elia M and Livesey G. Energy expenditure and fuel selection in biological systems: the theory and practice of calculations based on indirect calorimetry and tracer methods. World Rev Nutr Diet 70: 68-131, 1992.
18. Fryburg DA, Gelfand RA, and Barrett EJ. Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am J Physiol Endocrinol Metab 260: E499-E504, 1991.
19. Frystyk J, Dinesen B, and Ørskov H. Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II. Growth Regul 5: 169-176, 1995.
20. Goris AH, Meijer EP, and Westerterp KR. Repeated measurement of habitual food intake increases under-reporting and induces selective under-reporting. Br J Nutr 85: 629-634, 2001.
21. Heitmann BL. Evaluation of body fat estimated from body mass index, skinfolds and impedance. A comparative study. Eur J Clin Nutr 44: 831-837, 1990.
22. Ho KY and Weissberger AJ. The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system. Metabolism 39: 133-137, 1990.
23. Holloway L, Butterfield G, Hintz RL, Gesundheit N, and Marcus R. Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women. J Clin Endocrinol Metab 79: 470-479, 1994.
24. Hussain MA, Schmitz O, Mengel A, Keller A, Christiansen JS, Zapf J, and Froesch ER. Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans. J Clin Invest 92: 2249-2256, 1993.
25. Johannsson G, Marin P, Lonn L, Ottosson M, Stenlof K, Bjorntorp P, Sjostrom L, and Bengtsson BA. Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 82: 727-734, 1997.
26. Jørgensen JO, Pedersen SB, Børglum J, Møller N, Schmitz O, Christiansen JS, and Richelsen B. Fuel metabolism, energy expenditure, and thyroid function in growth hormone-treated obese women: a double-blind placebo-controlled study. Metabolism 43: 872-877, 1994.
27. Klausen B, Toubro S, and Astrup A. Age and sex effects on energy expenditure. Am J Clin Nutr 65: 895-907, 1997.
28. Lange KH, Isaksson F, Juul A, Rasmussen MH, Bülow J, and Kjaer M. Growth hormone enhances effects of endurance training on oxidative muscle metabolism in elderly women. Am J Physiol Endocrinol Metab 279: E989-E996, 2000.
29. Lange KH, Isaksson F, Rasmussen MH, Juul A, Bülow J, and Kjaer M. GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake. Clin Endocrinol (Oxf) 55: 77-86, 2001.
30. Lange KH, Larsson B, Flyvbjerg A, Dall R, Bennekou M, Rasmussen MH, Ørskov H, and Kjaer M. Acute growth hormone administration causes exaggerated increases in plasma lactate and glycerol during moderate to high intensity bicycling in trained young men. J Clin Endocrinol Metab 87: 4966-4975, 2002.
31. Lange KH, Lorentsen J, Isaksson F, Juul A, Rasmussen MH, Christensen NJ, Bülow J, and Kjaer M. Endurance training and GH administration in elderly women: effects on abdominal adipose tissue lipolysis. Am J Physiol Endocrinol Metab 280: E886-E897, 2001.
32. Marcus C, Bolme P, Micha-Johansson G, Margery V, and Bronnegard M. Growth hormone increases the lipolytic sensitivity for catecholamines in adipocytes from healthy adults. Life Sci 54: 1335-1341, 1994.
33. Marcus R, Butterfield G, Holloway L, Gilliland L, Baylink DJ, Hintz RL, and Sherman BM. Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab 70: 519-527, 1990.
34. Møller J, Jørgensen JO, Møller N, Christiansen JS, and Weeke J. Effects of growth hormone administration on fuel oxidation and thyroid function in normal man. Metabolism 41: 728-731, 1992.
35. Møller N, Jørgensen JO, Alberti KG, Flyvbjerg A, and Schmitz O. Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 70: 1179-1186, 1990.
36. Møller N, Møller J, Jørgensen JO, Ovesen P, Schmitz O, Alberti KG, and Christiansen JS. Impact of 2 weeks high dose growth hormone treatment on basal and insulin stimulated substrate metabolism in humans. Clin Endocrinol (Oxf) 39: 577-581, 1993.
37. Møller N, Schmitz O, Pørksen N, Møller J, and Jørgensen JO. Dose-response studies on the metabolic effects of a growth hormone pulse in humans. Metabolism 41: 172-175, 1992.
38. Nam SY, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, and Huh KB. Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients. Int J Obes Relat Metab Disord 25: 1101-1107, 2001.
39. Nørrelund H. The metabolic role of growth hormone in humans with particular reference to fasting. Growth Horm IGF Res 15: 95-122, 2005.
40. Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GA, Schambelan M, and Grunfeld C. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 124: 708-716, 1996.
41. Pedersen SB, Kristensen K, Fisker S, Jørgensen JO, Christiansen JS, and Richelsen B. Regulation of uncoupling protein-2 and -3 by growth hormone in skeletal muscle and adipose tissue in growth hormone-deficient adults. J Clin Endocrinol Metab 84: 4073-4078, 1999.
42. Rasmussen MH, Hvidberg A, Juul A, Main KM, Gotfredsen A, Skakkebaek NE, Hilsted J, and Skakkebae NE. Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects. J Clin Endocrinol Metab 80: 1407-1415, 1995.
43. Ravussin E, Lillioja S, Anderson TE, Christin L, and Bogardus C. Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest 78: 1568-1578, 1986.
44. Richelsen B. Effect of growth hormone on adipose tissue and skeletal muscle lipoprotein lipase activity in humans. J Endocrinol Invest 22: 10-15, 1999.
45. Richelsen B. Action of growth hormone in adipose tissue. Horm Res 48, Suppl 5: 105-110, 1997.
46. Richelsen B, Pedersen SB, Børglum JD, Møller-Pedersen T, Jørgensen J, and Jørgensen JO. Growth hormone treatment of obese women for 5 wk: effect on body composition and adipose tissue LPL activity. Am J Physiol Endocrinol Metab 266: E211-E216, 1994.
47. Rodriguez-Arnao J, Jabbar A, Fulcher K, Besser GM, and Ross RJ. Effects of growth hormone replacement on physical performance and body composition in GH deficient adults. Clin Endocrinol (Oxf) 51: 53-60, 1999.
48. Rosenfalck AM, Maghsoudi S, Fisker S, Jørgensen JO, Christiansen JS, Hilsted J, Volund AA, and Madsbad S. The effect of 30 months of low-dose replacement therapy with recombinant human growth hormone (rhGH) on insulin and C-peptide kinetics, insulin secretion, insulin sensitivity, glucose effectiveness, and body composition in GH-deficient adults. J Clin Endocrinol Metab 85: 4173-4181, 2000.
49. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, and Mattson DE. Effects of human growth hormone in men over 60 years old. N Engl J Med 323: 1-6, 1990.
50. Russell-Jones DL, Umpleby AM, Hennessy TR, Bowes SB, Shojaee-Moradie F, Hopkins KD, Jackson NC, Kelly JM, Jones RH, and Sonksen PH. Use of a leucine clamp to demonstrate that IGF-I actively stimulates protein synthesis in normal humans. Am J Physiol Endocrinol Metab 267: E591-E598, 1994.
51. Sandström B. Nordiska Näringsrekommendationer. Copenhagen, Denmark: Nordiska Ministerräd, 1996.
52. Segerlantz M, Bramnert M, Manhem P, Laurila E, and Groop LC. Inhibition of lipolysis during acute GH exposure increases insulin sensitivity in previously untreated GH-deficient adults. Eur J Endocrinol 149: 511-519, 2003.
53. Snel YE, Doerga ME, Brummer RJ, Zelissen PM, Zonderland ML, and Koppeschaar HP. Resting metabolic rate, body composition and related hormonal parameters in growth hormone-deficient adults before and after growth hormone replacement therapy. Eur J Endocrinol 133: 445-450, 1995.
54. Tessari P, Nissen SL, Miles JM, and Haymond MW. Inverse relationship of leucine flux and oxidation to free fatty acid availability in vivo. J Clin Invest 77: 575-581, 1986.
55. Thompson JL, Butterfield GE, Marcus R, Hintz RL, Van Loan M, Ghiron L, and Hoffman AR. The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women. J Clin Endocrinol Metab 80: 1845-1852, 1995.
56. Toogood AA and Shalet SM. Ageing and growth hormone status. Baillieres Clin Endocrinol Metab 12: 281-296, 1998.
57. Toubro S, Sørensen TI, Hindsberger C, Christensen NJ, and Astrup A. Twenty-four-hour respiratory quotient: the role of diet and familial resemblance. J Clin Endocrinol Metab 83: 2758-2764, 1998.
58. Toubro S, Sørensen TI, Ronn B, Christensen NJ, and Astrup A. Twenty-four-hour energy expenditure: the role of body composition, thyroid status, sympathetic activity, and family membership. J Clin Endocrinol Metab 81: 2670-2674, 1996.
59. Turkalj I, Keller U, Ninnis R, Vosmeer S, and Stauffacher W. Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man. J Clin Endocrinol Metab 75: 1186-1191, 1992.
60. Wolthers T, Grøfte T, Nørrelund H, Poulsen PL, Andreasen F, Christiansen JS, and Jørgensen JO. Differential effects of growth hormone and prednisolone on energy metabolism and leptin levels in humans. Metabolism 47: 83-88, 1998.
61. Yarasheski KE, Campbell JA, Smith K, Rennie MJ, Holloszy JO, and Bier DM. Effect of growth hormone and resistance exercise on muscle growth in young men. Am J Physiol Endocrinol Metab 262: E261-E267, 1992.
62. Yuen K, Frystyk J, Umpleby M, Fryklund L, and Dunger D. Changes in free rather than total insulin-like growth factor-I enhance insulin sensitivity and suppress endogenous peak growth hormone (GH) release following short-term low-dose GH administration in young healthy adults. J Clin Endocrinol Metab 89: 3956-3964, 2004.
63. Yuen K, Wareham N, Frystyk J, Hennings S, Mitchell J, Fryklund L, and Dunger D. Short-term low-dose growth hormone administration in subjects with impaired glucose tolerance and the metabolic syndrome: effects on beta-cell function and post-load glucose tolerance. Eur J Endocrinol 151: 39-45, 2004.
64. Ziegler TR, Young LS, Manson JM, and Wilmore DW. Metabolic effects of recombinant human growth hormone in patients receiving parenteral nutrition. Ann Surg 208: 6-16, 1988.