Inactivation of herpes simplex virus clinical isolates by using a combination microbicide

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 3, 2006, Pages 1063-1066

  Isaacs, Charles E ^a   Rohan, Lisa ^b   Xu, Weimin ^a   Jia, Jun Hua ^a   Mietzner, Timothy ^c   Hillier, Sharon ^d  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 O OCTYLGLYCEROL; ETHER DERIVATIVE; LIPID ETHER; MICROBICIDE; PEPTIDE; PEPTIDE LSA5; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 2; LIPID BILAYER; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; STRAIN DIFFERENCE; VERTICAL TRANSMISSION; VIRUS ENVELOPE; VIRUS INACTIVATION; VIRUS INFECTION; VIRUS ISOLATION; VIRUS STRAIN;

ANTIVIRAL AGENTS; DRUG COMBINATIONS; GLYCERYL ETHERS; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; KINETICS; PEPTIDES;

EID: 33644657048     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.3.1063-1066.2006     Document Type: Article

References (13)

1. Isaacs, C. E., and M. F. Lampe. 2000. Lactolipids, p. 159-182. In A. S. Naidu (ed.), Natural food antimicrobial systems. CRC Press, Boca Raton, Fla.
2. Isaacs, C. E., J. H. Jia, and W. Xu. 2004. A lipid-peptide microbicide inactivates herpes simplex virus. Antimicrob. Agents Chemother. 48:3182-3184.
3. Lampe, M. F., L. M. Ballweber, C. E. Isaacs, D. L. Patton, and W. E. Stamm. 1998. Killing of Chlamydia trachomatis by novel antimicrobial lipids adapted from compounds in human breast milk. Antimicrob. Agents Chemother. 42:1239-1244.
4. Moore, J. P. 2005. Topical microbicides become topical. N. Engl. J. Med. 352:298-300.
5. Phadke, S. M., K. Islam, B. Deslouches, D. B. Stolz, S. C. Watkins, R. C. Montelaro, J. M. Pilewski, and T. A. Mietzner. 2003. Selective toxicity of engineered lentivirus lytic peptides in a cystic fibrosis airway cell model. Peptides 24:1099-1107.
6. Reed, L. J., and M. Muench. 1938. A simple method of estimating 50 percent end points. Am. J. Hyg. 27:493-497.
7. Tencza, S. B., D. J. Creighton, T. Yuan, H. J. Vogel, R. C. Montelaro, and T. A. Mietzner. 1999. Lentivirus-derived antimicrobial peptides: increased potency by sequence engineering and dimerization. J. Antimicrob. Chemother. 44:33-41.
8. Tencza, S. B., J. P. Douglass, D. J. Creighton, Jr., R. C. Montelaro, and T. A. Mietzner. 1997. Novel antimicrobial peptides derived from human immunodeficiency virus type 1 and other lentivirus transmembrane proteins. Antimicrob. Agents Chemotber. 41:2394-2398.
9. Thormar, H., C. E. Isaacs, H. R. Brown, M. R. Barshatzky, and T. Pessolano. 1987. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglyccrides. Antimicrob. Agents Chemother. 31:27-31.
10. Verdonck, L. F., and H. G. van Heugten. 1997. Ether lipids are effective cytotoxic drugs against multidrug-resistant acute leukemia cells and can act by the induction of apoptosis. Leukemia Res. 21:37-43.
11. Weber, J., K. Desai, J. Darbyshire, and the Microbicides Development Programme. 2005. The development of vaginal microbicides for the prevention of HIV transmission. PloS Med. 2:e142.
12. Whitley, R. J., and B. Roizman. 2002. Herpes simplex viruses: is a vaccine tenable? J. Clin. Investig. 109:145-151.
13. Zasloff, M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415:389-395.