Intracervical application of the nitric oxide donor isosorbide dinitrate for induction of cervical ripening: A randomised controlled trial to determine clinical efficacy and safety prior to first trimester surgical evacuation of retained products of conception

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 112, Issue 12, 2005, Pages 1615-1619

  Arteaga Troncoso, Gabriel ^a   Villegas Alvarado, Alejandro ^b   Belmont Gomez, Aurora ^a   Martinez Herrera, Francisco J ^b   Villagrana Zesati, Roberto ^a   Guerra Infante, Fernando ^a  

^a INSTITUTO NACIONAL DE PERINATOLOGÍA   (Mexico)

^b National Defense Ministry   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ISOSORBIDE DINITRATE; MISOPROSTOL; NITRIC OXIDE DONOR;

ABDOMINAL PAIN; ADULT; ARTICLE; BACKACHE; CLINICAL TRIAL; CONCEPTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FIRST TRIMESTER PREGNANCY; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MISSED ABORTION; NAUSEA; PELVIS PAIN SYNDROME; PRIORITY JOURNAL; PROBABILITY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; SYSTOLIC BLOOD PRESSURE; UTERINE CERVIX RIPENING; UTERINE ENDOCERVIX; VOMITING; DRUG EFFECT; GEL; INDUCED ABORTION; METHODOLOGY; PREGNANCY; RETAINED PLACENTA; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ABORTION, INDUCED; ADMINISTRATION, TOPICAL; CERVICAL RIPENING; DOUBLE-BLIND METHOD; FEMALE; GELS; HUMANS; ISOSORBIDE DINITRATE; NITRIC OXIDE DONORS; PLACENTA, RETAINED; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 33644656146     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2005.00760.x     Document Type: Article

References (19)

1. Schultz KF, Grimes DA, Cates WJ. Measures to prevent cervical injury during suction curettage abortion. Lancet 1983 1 : 1182 1184.
2. El-Refaey H, Calder L, Wheatley DN, Templeton A. Cervical priming with prostagladin E1 analogues, misoprostol and gemeprost. Lancet 1994 343 : 1207 1209.
3. Wing DA, Rahal A, Jones MM, Goodwin M, Paul RH. Misoprostol: an effective agent for cervical ripening and labor induction. Am J Obstet Gynecol 1995 172 : 1811 1816.
4. Änggård E. Nitric oxide: mediator, murderer, and medicine. Lancet 1994 343 : 1199 1206.
5. Thomson AJ, Lunan CB, Cameron AD, et al. Nitric oxide donors induce ripening of the human uterine cervix: a randomised controlled trial. Br J Obstet Gynaecol 1997 104 : 1054 1057.
6. Thomson AJ, Lunan CB, Ledingham M, et al. Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first trimester termination of pregnancy. Lancet 1998 352 : 1093 1096.
7. Mercier F, Dounas M, Bouaziz H, et al. Intravenous nitroglycerin to relive intrapartum fetal distress related to uterine hyperactivity: a prospective observational study. Anesth Analg 1997 84 : 1117 1120.
8. Norman J, Ward L, Martin W, et al. Effects of cGMP and the nitric oxide donors glyceryl trinitrate and sodium nitroprusside on contractions in vitro of isolated myometrial tissue from pregnant women. J Reprod Fertil 1997 110 : 249 254.
9. Howie PW. Abortion and ectopic pregnancy. In: Whitfield CR, editor. Dewhurst's Textbook of Obstetrics and Gynaecology for Postgraduates. London : Blackwell Scientific Publications, 1986 : 165 187.
10. Rowlands S, Trudinger B, Visva-Lingam S. Treatment of preterm cervical dilatation with glyceryl trinitrate, a nitric oxide donor. Aust N Z J Obstet Gynaecol 1996 36 : 377 381.
11. David M, Halle H, Lichtenegger W, Sinha P, Zimmermann T. Nitroglycerin to facilitate fetal extraction during cesarean delivery. Obstet Gynecol 1998 91 : 119 124.
12. Peng A, Gorman R, Shulman S, et al. Intravenous nitroglycerin for uterine relaxation in the postpartum patient with retained placenta. Anesthesiology 1989 71 : 172 173.
13. Espey MG, Miranda KM, Feelisch M, et al. Mechanisms of cell death governed by balance between nitrosative and oxidative stress. Ann N Y Acad Sci 2000 899 : 209 221.
14. Espey MG, Miranda KM, Thomas DD, et al. A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. In: Chiurh C, Hong J, Leong S, editors. Nitric oxide. Novel actions, deleterious effects, and clinical potential. Ann N Y Acad Sci 2002 : 195 206.
15. Lin KT, Xue JY, Nomen M, et al. Peroxynitrite-induced apoptosis in HL-60 cells. J Biol Chem 1995 270 : 16487 16490.
16. Wink D, Miranda KM, Espey MG. Cytotoxicity related to oxidative and nitrosative stress by nitric oxide. Exp Biol Med 2001 226 : 621 623.
17. Salvemini D, Misko TP, Masferrer JL, et al. Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci 1993 90 : 7240 7244.
18. Trachtman H, Futterweit S, Garg P, Reddy K, Singhal PC. Nitric oxide stimulates the activity of a 72-Kda neutral matrix metalloproteinase in cultured rat mesangial cells. Biochem Biophys Res Commun 1996 218 : 704 708.
19. Nicoll AE, Mackenzie F, Greer IA, Norman JE. Vaginal application of the nitric oxide donor isosorbide mononitrate for preinduction cervical ripening: a randomized controlled trial to determine effects on maternal and fetal hemodynamics. Am J Obstet Gynecol 2001 184 : 958 964.