A methodology for the design of scale-down bioreactors by the use of mixing and circulation stochastic models

Biochemical Engineering Journal

Volumn 28, Issue 3, 2006, Pages 256-268

  Delvigne, F ^a   Destain, J ^a   Thonart, P ^a  

^a WALLOON AGRICULTURAL RESEARCH CENTRE   (Belgium)

Author keywords

Bioreactors; Circulation; Mixing; Modelling; Scale down; Stochastic

Indexed keywords

HYDRODYNAMICS; MATHEMATICAL MODELS; MIXING; STOCHASTIC CONTROL SYSTEMS;

CIRCULATION; SCALE-DOWN;

BIOREACTORS;

ARTICLE; BIOREACTOR DESIGN; CIRCULATION; HYDRODYNAMICS; INTERMETHOD COMPARISON; METHODOLOGY; PRIORITY JOURNAL; SCALE UP; STOCHASTIC MODEL;

EID: 33644655595     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2005.11.009     Document Type: Article

References (28)

1. P.K. Namdev, B.G. Thompson, and M.R. Gray Effect of feed zone in fed-batch fermentations of Saccharomyces cerevisiae Biotechnol. Bioeng. 40 2 1992 235 246
2. J.D. Fowler, and E.H. Dunlop Effects of reactant heterogeneity and mixing on catabolite repression in cultures of Saccharomyces cerevisiae Biotechnol. Bioeng. 33 1989 1039 1046
3. P. Neubauer, L. Häggström, and S.O. Enfors Influence of substrate oscillations on acetate formation and growth yield in Escherichia coli glucose limited fed-batch cultivations Biotechnol. Bioeng. 47 1995 139 146
4. S.O. Enfors, M. Jahic, A. Rozkov, B. Xu, M. Hecker, B. Jürgen, E. Krüger, T. Schweder, G. Hamer, D. O'Beirne, N. Noisommit-Rizzi, M. Reuss, L. Boone, C. Hewitt, C. McFarlane, A. Nienow, T. Kovacs, C. Trägardh, L. Fuchs, J. Revstedt, P.C. Friberg, B. Hjertager, G. Blomsten, H. Skogman, S. Hjort, F. Hoeks, H.Y. Lin, P. Neubauer, R. van der Lans, K. Luyben, P. Vrabel, and A. Manelius Physiological responses to mixing in large scale bioreactors J. Biotechnol. 85 2001 175 185
5. A. Amanullah, Farlane.C.M. Mac, A.N. Emery, and A.W. Nienow Scale-down model to simulate spatial pH variations in large-scale bioreactors Biotechnol. Bioeng. 73 5 2001 390 399
6. C.J. Hewitt, G. Nebe-Von Caron, B. Axelsson, C.M. Mc Farlane, and A.W. Nienow Studies related to the scale-up of high-cell-density E. coli fed-batch fermentations using multiparameter flow cytometry: effect of a changing microenvironment with respect to glucose and dissolved oxygen concentration Biotechnol. Bioeng. 70 4 2000 381 390
7. R.W. Lovitt, and J.W.T. Wimpenny The gradostat: a bidirectional compound chemostat and its application in microbiological research J. Gen. Microbiol. 127 1981 261 268
8. R.D. Tanner, I.J. Dunn, J.R. Bourne, and M.K. Klu The effect of imperfect mixing on an idealized kinetic fermentation model Chem. Eng. Sci. 40 7 1985 1213 1219
9. N.M.G. Oosterhuis, N.W.F. Kossen, A.P.C. Olivier, and E.S. Schenk Scale-down and optimization studies of the gluconic acid fermentation by Gluconobacter oxydans Biotechnol. Bioeng. 27 1985 711 720
10. A.P.J. Sweere, L. Janse, K.C.A.M. Luyben, and N.W.F. Kossen Experimental simulation of oxygen profiles and their influence on baker's yeast production Part 2: two-fermentor system Biotechnol. Bioeng. 31 1988 579 586
11. N.M.G. Oosterhuis, N.M. Groesbeek, A.P.C. Olivier, and N.W.F. Kossen Scale-down aspects of the gluconic acid fermentation Biotechnol. Lett. 5 3 1983 141 146
12. P.K. Namdev, P.K. Yegneswaran, B.G. Thompson, and M.R. Gray Experimental simulation of large-scale bioreactor environments using a monte carlo method Can. J. Chem. Eng. 69 1991 513 519
13. A.P.J. Sweere, J.R. Mesters, L. Janse, K.C.A.M. Luyben, and N.W.F. Kossen Experimental simulation of oxygen profiles and their influence on Baker's yeast production Part I: one-fermentor system Biotechnol. Bioeng. 31 1988 567 578
14. B.G. Thompson Effect of temporary localized operating conditions on fermentations of Saccharomyces cerevisiae Biotechnol. Bioeng. 29 1987 786 788
15. H.K. Lin, and P. Neubaueur Influence of controlled glucose oscillations on a fed-batch process of recombinant Escherichia coli J. Biotechnol. 79 2000 27 37
16. B.M. Schilling, W. Pfefferle, B. Bachmann, W. Leuchtenberger, and W.D. Deckwer A special reactor design for investigations of mixing time effects in a scaled-down industrial l-lysine fed-batch fermentation process Biotechnol. Bioeng. 64 5 1999 599 606
17. B. Mayr, P. Horvat, and A. Moser Engineering approach to mixing quantification in bioreactors Bioprocess Eng. 8 1992 137 143
18. H. Berthiaux Analysis of grinding processes by Markov chains Chem. Eng. Sci. 55 2000 4117 4127
19. H. Berthiaux, and J. Dodds Modeling classifier networks by Markov chains Powder Technol. 105 1999 266 273
20. L.T. Fan, L.S. Fan, and R.F. Nassar A stochastic model of the unsteady state age distribution in a flow system Chem. Eng. Sci. 34 1979 1172 1174
21. M. Rubinovitch, and U. Mann Single-particle approach for analyzing flow systems Part I: visits to flow regions AIChE J. 29 4 1983 658 662
22. F. Delvigne, J. Destain, and P. Thonart Structured mixing model for stirred bioreactors: an extension to the stochastic approach Chem. Eng. J. 113 2005 1 12
23. R. Mann, P.P. Mavros, and J.C. Middleton A structured stochastic flow model for interpreting flow-follower data from a stirred vessel Trans. IChemE 59 1981 271 278
24. P. Vrabel, R.G.J.M. van der Lans, K.Ch.A.M. Luyben, L. Boon, and A.N. Nienow Mixing in large-scale vessels stirred with multiple radial or radial and axial up-pumping impellers: modelling and measurements Chem. Eng. Sci. 55 2000 5881 5896
25. F. Delvigne, M.T. El Mejdoub, J. Destain, J.M. Delroisse, M. Vandenbol, E. Haubruge, and P. Thonart Estimation of bioreactor efficiency through structured hydrodynamic modelling: case study of a Pichia pastoris fed-batch process Appl. Biochem. Biotechnol. 121-124 2005 653 671
26. A.W. Nienow Hydrodynamics of stirred bioreactors Appl. Mech. Rev. 51 1 1998 3 32
27. R.K. Bajpai, and M. Reuss Coupling of mixing and microbial kinetics for evaluating the performance of bioreactor Can. J. Chem. Eng. 60 1982 384 392
28. K.J. Bittorf, and S.M. Kresta Active volume of mean circulation for stirred tank agitated with axial impellers Chem. Eng. Sci. 55 2000 1325 1335