Tumor cell dissociation score highly correlates with lymph node metastasis in superficial esophageal carcinoma

Journal of Gastroenterology and Hepatology (Australia)

Volumn 20, Issue 9, 2005, Pages 1371-1378

  Chibana, Yoko ^a   Fujii, Shigehiko ^a   Ichikawa, Kazuhito ^a   Fujita, Mikio ^a   Ono, Yuko ^a   Tomita, Shigeki ^a   Imura, Johji ^a   Kawamata, Hitoshi ^a   Terano, Akira ^a   Fujimori, Takahiro ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

E cadherin; Immunohistochemistry; Lymph node metastasis; Superficial esophageal squamous cell carcinoma; Tumor cell dissociation

Indexed keywords

UVOMORULIN; CADHERIN;

ADULT; AGED; ARTICLE; CANCER INVASION; ESOPHAGUS CARCINOMA; ESOPHAGUS MUCOSA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOGISTIC REGRESSION ANALYSIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; SQUAMOUS CELL CARCINOMA; TUMOR CELL; CANCER STAGING; CHEMISTRY; CLASSIFICATION; ESOPHAGUS; ESOPHAGUS RESECTION; ESOPHAGUS TUMOR; LYMPH NODE; MIDDLE AGED; MUCOSA; PATHOLOGY; PREDICTION AND FORECASTING;

AGED; CADHERINS; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; ESOPHAGUS; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MUCOUS MEMBRANE; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS;

EID: 33644653323     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2005.03858.x     Document Type: Article

References (36)

1. Wang LS, Chow KC, Chi KH et al. Prognosis of esophageal squamous cell carcinoma: analysis of clinicopathological and biological factors. Am. J. Gastroenterol. 1999 94 : 1933 40.
2. Shimada Y, Imamura M, Watanabe G et al. Prognostic factors of oesophageal squamous cell carcinoma from perspective of molecular biology. Br. J. Cancer 1999 80 : 1281 8.
3. Watanabe M, Kuwano H, Araki K et al. Prognostic factors in patients with submucosal carcinoma of the esophagus. Br. J. Cancer 2000 83 : 609 13.
4. Nakanishi Y, Ochiai A, Kato H, Tachimori Y, Igaki H, Hirohashi S. Clinicopathological significance of tumor nest configuration in patients with esophageal squamous cell carcinoma. Cancer 2001 91 : 1114 20.
5. Youssef EM, Matsuda T, Takada N et al. Prognostic significance of the MIB-1 proliferation index for patients with squamous cell carcinoma of the esophagus. Cancer 1995 76 : 358 66.
6. Harada H, Tanaka H, Shimada Y, Shinoda M, Imamura M, Ishizaki K. Lymph node metastasis associated with allelic loss on chromosome13q12-13 in esophageal squamous cell carcinoma. Cancer Res. 1999 59 : 3724 9.
7. Noguchi T, Kimura Y, Takeno S et al. Chromosomal imbalance in esophageal squamous cell carcinoma: 3q gain correlates with tumor progression but not prognostic significance. Oncol. Rep. 2003 10 : 1393 400.
8. Kitadai Y, Amioka T, Haruma K et al. Clinicopathological significance of vascular endothelial growth factor (VEGF)-C in human esophageal squamous cell carcinomas. Int. J. Cancer 2001 93 : 662 6.
9. Tachibana M, Kinugasa S, Dhar DK et al. Dukes' classification as a useful staging system in resectable squamous cell carcinoma of the esophagus. Virchows Arch. 2001 438 : 350 6.
10. Tajima Y, Nakanishi Y, Ochiai A et al. Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma. Cancer 2000 88 : 1285 93.
11. Broders AC. Squamous-cell epithelioma of the lip. A study of five hundred and thirty-seven cases. JAMA 1920 74 : 654 64.
12. Gabbert H, Wagner R, Moll R, Gerharz CD. Tumor dedifferentiation: an important step in tumor invasion. Clin. Exp. Metastasis 1985 3 : 257 79.
13. Okuyama T, Oya M, Ishikawa H. Budding as a useful prognostic marker in pT3 well- or moderately-differentiated rectal adenocarcinoma. J. Surg. Oncol. 2003 83 : 42 7.
14. Gabbert HE, Meier S, Gerharz CD, Hommel G. Tumor-cell dissociation at the invasion front: a new prognostic parameter in gastric cancer patients. Int. J. Cancer 1992 50 : 202 7.
15. Imai T. Growth patterns in human carcinoma. Their classification and relation to prognosis. Obstet. Gynecol. 1960 16 : 296 308.
16. Hase K, Shatney C, Johnson D, Trollope M, Vierra M. Prognostic value of tumor 'budding' in patients with colorectal cancer. Dis. Colon Rectum 1993 36 : 627 35.
17. Pyke C, Salo S, Ralfkiaer E, Romer J, Dano K, Tryggvason K. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res. 1995 55 : 4132 9.
18. Okabe S, Kanenobu M, Matsumoto A et al. Controversy on therapeutic modality to early colorectal carcinomas from the viewpoint of histopathological features. Nippon Geka Gakkai Zasshi 1992 93 : 1079 82.
19. Ono M, Sakamoto M, Ino Y et al. Cancer cell morphology at the invasive front and expression of cell adhesion-related carbohydrate in the primary lesion of patients with colorectal carcinoma with liver metastasis. Cancer 1996 78 : 1179 86.
20. Shiozaki H, Tahara H, Oka H et al. Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am. J. Pathol. 1991 139 : 17 23.
21. Shimoyama Y, Hirohashi S, Hirano S et al. Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res. 1989 49 : 2128 33.
22. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991 251 : 1451 5.
23. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, Birchmeier W. E-cadherin expression in squamous cell carcinoma of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res. 1991 51 : 6328 37.
24. Sulzler MA, Leers MPG, van Noord JA, Bollen ECM, Theunissen PHMH. Reduction E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer. Am. J. Respir. Crit. Care Med. 1998 157 : 1319 23.
25. Umbas R, Isaccs WB, Bringuier PP et al. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res. 1994 54 : 3929 33.
26. Pignatelli M, Ansari TW, Gunter P et al. Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade, and advanced stage. J. Pathol. 1994 174 : 243 8.
27. Kadowaki T, Shiozaki H, Inoue M et al. E-cadherin and alpha-catenin expression in human esophageal cancer. Cancer Res. 1994 54 : 291 6.
28. Japanese Society for Esophageal Disease. Guidelines for the Clinical and Pathologic Studies on Carcinoma of the Esophagus. Japan : Kanehara Shuppan, 1999.
29. Kaihara T, Kusaka T, Kawamata H et al. Decreased expression of E-cadherin and Yamamoto-Kohama's mode of invasion highly correlates with lymph node metastasis in esophageal squamous cell carcinoma. Pathobiology 2001 69 : 172 8.
30. Kodama M, Kakegawa T. Treatment of superficial cancer of the esophagus: a summary of responses to a questionnaire on superficial cancer of the esophagus in Japan. Surgery 1998 123 : 432 9.
31. Araki K, Ohno S, Egashira A, Saeki H, Kawaguchi H, Sugimachi K. Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis. Cancer 2002 94 : 570 5.
32. Tachibana M, Yoshimura H, Kinugasa S et al. Clinicopathological features of superficial squamous cell carcinoma of the esophagus. Am. J. Surg. 1997 174 : 49 53.
33. Tamura S, Shiozaki H, Miyata M et al. Decreased E-cadherin expression is associated with haematogenous recurrence and poor prognosis in patients with squamous cell carcinoma of the oesophagus. Br. J. Surg. 1996 83 : 1608 14.
34. Doki Y, Shiozaki H, Tahara H et al. Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Res. 1993 53 : 3421 6.
35. Peng YF Mandai K Nakanishi H et al. Restoration of E-cadherin-based cell-cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line. Oncogene 2002 21 : 4108 19.
36. Shiozaki H, Kadowaki T, Doki Y et al. Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line. Br. J. Cancer 1995 71 : 250 8.