CDK inhibitor targets: A hit or miss proposition? Cyclin-dependent kinase inhibitors kill tumor cells by downregulation of anti-apoptotic proteins

Cancer Biology and Therapy

Volumn 5, Issue 2, 2006, Pages 171-173

  Dai, Yun ^a   Grant, Steven ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Anti apoptotic proteins; Apoptosis; CDK inhibitors; Cyclin dependent kinases; Transcriptional regulation

Indexed keywords

BAG 1 PROTEIN; CYCLIN A; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2 INHIBITOR; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE 9; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; CYCLINE; FLAVOPIRIDOL; GW 8510; HOLOENZYME; INHIBITOR OF APOPTOSIS PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; PROTEIN SERINE KINASE; RETINOBLASTOMA PROTEIN; ROSCOVITINE; SMALL NUCLEAR RNA; SURVIVIN; THREONINE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER THERAPY; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; DISEASE COURSE; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; GENOME; GROWTH INHIBITION; HUMAN; LUNG NON SMALL CELL CANCER; MITOSIS; NONHUMAN; NOTE; PROGNOSIS; PROTEIN EXPRESSION; TUMOR CELL;

EID: 33644651461     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.5.2.2568     Document Type: Note

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