Prions in dentistry - What are they, should we be concerned, and what can we do?

Journal of the Canadian Dental Association

Volumn 72, Issue 1, 2006, Pages 53-60

  Azarpazhooh, Amir ^a   Leake, James L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Dental care; Infection control, dental; Prion diseases transmission; Risk factors

Indexed keywords

ANIMAL; BLOOD TRANSFUSION; CANADA; DENTAL CARE; DENTAL EQUIPMENT; DISEASE TRANSMISSION; EQUIPMENT; HUMAN; INFECTION CONTROL; METHODOLOGY; PRACTICE GUIDELINE; PRION DISEASE; REVIEW; RISK FACTOR; WORLD HEALTH ORGANIZATION;

ANIMALS; BLOOD TRANSFUSION; CANADA; DENTAL CARE FOR CHRONICALLY ILL; DENTAL INSTRUMENTS; DISEASE TRANSMISSION, HORIZONTAL; EQUIPMENT CONTAMINATION; GUIDELINES; HUMANS; INFECTION CONTROL, DENTAL; PRION DISEASES; RISK FACTORS; WORLD HEALTH ORGANIZATION;

EID: 33644643206     PISSN: 14882159     EISSN: 14882159     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Prusiner SB. Prions. Proc Natl Acad Sci USA 1998; 95(23):13363-83.
2. Prusiner SB. Prion diseases and the BSE crisis. Science 1997; 278(5336):245-51. Available from: URL: www.sciencemag.org.
3. Prusiner SB. Molecular biology and pathogenesis of prion diseases. Trends Biochem Sci 1996; 21(12):482-7.
4. Health Canada. Classic Creutzfeldt-Jakob disease in Canada. Infection control guidelines. Can Commun Dis Rep 2002; 2855:1-84. Available from: URL: http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/02pdf/28s5e.pdf (accessed December 22, 2005).
5. Public Health Agency of Canada. Classical Creutzfeldt-Jakob Disease: Creutzfeldt-Jakob Disease Surveillance System(CJD-SS); 2003. Available from: URL: http://www.phac-aspc.gc.ca/hcai-iamss/cjd-mcj/cjdss_e.html#stats (accessed December 22, 2005).
6. Gibbons RV, Holman RC, Belay ED, Schonberger LB. Creutzfeldt-Jakob disease in the United States: 1979-1998. JAMA 2000; 284(18):2322-3.
7. Will R. Acquired prion disease: iatrogenic CJD, variant CJD, kuru. British Medical Bulletin 2003; 66:255-65.
8. Kompoliti K, Goetz C, Gajdusek D, Cubo E. Movement disorders in Kuru. Movement Disorders 1999; 14(5):800-4.
9. Porter SR. Prion disease: possible implications for oral health care. J Am Dent Assoc 2003; 134(11):1486-91.
10. From the Centers for Disease Control and Prevention. Probable variant Creutzfeldt-Jakob disease in a US Resident-Florida, 2002. JAMA 2002; 288(23):2965-7.
11. Chan SW, Collins S, Masters CL, Walker DM. Classical and variant Creutzfeldt-Jakob diseases and their potential impact on the practice of clinical dentistry in Australia. Aust Dent J 2001; 46(4):251-7.
12. Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alperovitch A, and others. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 1996; 347(9006):921-5.
13. Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, and others. Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nat Med 1997; 398(6650):498-501.
14. Health Canada. First case of variant Creutzfeldt-Jakob disease in Canada. Can Commun Dis Rep 2003; 29(13):117-20. Available from: URL: http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/03vol29/dr2913eb.html (accessed December 22, 2005).
15. Spongiform Encephalopathy Advisory Committee. SEAC Annual Report 2003. Available from: URL: http://www.seac.gov.uk/publicats/annualreport2003.pdf (accessed December 22, 2005).
16. Keogh PV, Flint SR. Transmissible spongiform encephalopathies and dentistry. J Ir Dent Assoc 2004; 50(4):160-2.
17. World Health Organization. Fact sheet no 113: Bovine spongiform encephalopathy. November 2002. Available from: URL: http://www.who.int/ mediacentre/factsheets/fs113/en/index.html (accessed December 22, 2005).
18. Smith AJ, Russell DI, Greene J, Lowman A, Ironside JW. Presentation of a case of variant CJD in general dental practice. Br Dent J 2004; 197(2):75-6.
19. Health Canada. Advisory notice: infection control for Creutzfeldt-Jakob disease. Can Commun Dis Rep 1996; 22(17):147-8. Available from: URL: http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/96vol22/dr2217ec.html (accessed December 22, 2005).
20. Collins S, Law MG, Fletcher A, Boyd A, Kaldor J, Masters CL. Surgical treatment and risk of sporadic Creutzfeldt-Jakob disease: a case-control study. Lancet 1999; 353(9154):693-7.
21. Comer P. Risk assessment of exposure to vCJD infectivity in blood and blood products. Report for Department of Health. 2003. Available from: URL: http://www.dnv.com/binaries/vCJD_Update_Report_tcm4-74414.pdf (accessed November 2005).
22. van Duijn CM, Delasnerie-Laupretre N, Masullo C, Zerr I, de Silva R, Wientjens DP, and others. Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993-95. European Union (EU) Collaborative Study Group of Creutzfeldt-Jakob disease (CJD). Lancet 1998; 35(9109):1081-5.
23. Houston F, Foster JD, Chong A, Hunter N, Bostock CJ. Transmission of BSE by blood transfusion in sheep, Lancet 2000; 356(9234):999-1000.
24. Hunter N, Foster J, Chong A, McCutcheon S, Parnham D, Eaton S, and others. Transmission of prion diseases by blood transfusion. J Gen Virol 2002; 83(Pt 11):2897-905.
25. Taylor DM, Fernie K, Reichl HE, Somerville RA. Infectivity in the blood of mice with a BSE-derived agent. J Hosp Infect 2000; 46(1):78-9.
26. Llewelyn CA, Hewitt PE, Knight RS, Amar K, Cousens S, Mackenzie J, and other. Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet 2004; 363(9407):417-21.
27. Public Health Agency of Canada. Variant Creutzfeldt-Jakob disease (vCJD) in Canada. Available from: URL: http://www.phac-aspc.gc.ca/cjd-mcj/vcjd-faq_e. html (accessed December 22, 2005).
28. World Health Organization Consultation. WHO Infection Control Guidelines for Transmissible Spongiform Encephalopathies. [monograph on the Internet]. Geneva, Switzerland: World Health Organization Communicable Disease Surveillance and Control; 1999 [cited 2005 Feb 24], Available from: URL: http://www.who.int/csr/resources/publications/bse/whocdscsraph2003.pdf (accessed December 22, 2005).
29. Porter SR. Prions and dentistry. J R Soc Med 2002; 95(4):178-81.
30. Scully C, Smith AJ, Bagg J. Prions and the human transmissible spongiform encephalopathies. Dent Clin North Am 2003; 47(3):493-516.
31. Department of Health, England. Advisory Committee on Dangerous Pathogens and the Spongiform Encephalopathy Advisory Committee. Transmissible spongiform encephalopathy agents: safe working and the prevention of infection. 2003 (Table 4A updated July 2005). Available from: URL: http://www.advisorybodies.doh.gov. uk/acdp/tseguidance/ (accessed December 22, 2005).
32. Head MW, Ritchie D, McLoughlin V, Ironside JW. Investigation of PrPres in dental tissues in variant CJD. Br Dent J 2003; 195(6)339-43.
33. Porter S, Scully C, Ridgway GL, Bell J. The human transmissible spongiform encephalopathies (TSEs): implications for dental practitioners. Br Dent J 2000; 188(8):432-6.
34. Gonzales TS, Rushing EJ. Bad news and good news: what the dentist needs to know about transmissible spongiform encephalopathies. Quintessence Int 1998; 29(5):319-21.
35. Sogal A, Tofe A. Risk assessment of bovine spongiform encephalopathy transmission through bone graft material derived from bovine bone used for dental applications. J Periodontol 1999; 70(9):1053-63.
36. UK Department of Health. Economics and Operational Research Division. Risk assessment for vCJD and dentistry. July 2003. Available from: URL: http://www.dh.gov.uk/assetRoot/04/07/83/03/04078303.PDF (accessed December 22, 2005).
37. Kondo K, Kuroiwa Y. A case control study of Creutzfeldt-Jakob disease: association with physical injuries. Ann Neural 1982; 11(4):377-81.
38. Blanquet-Grossard F, Sazdovitch V, Jean A, Deslys JP, Dormont D, Hauw JJ, and others. Prion protein is not detectable in dental pulp from patients with Creutzfeldt-Jakob disease. J Dent Res 2000; 79(2):700.
39. Adams D, Edgar WM. Transmission of agent of Creutzfeldt-Jakob disease. Br Med J 1978; 1(6118):987.
40. Carp RI. Transmission of scrapie by oral route: effect of gingival scarification. Lancet 1982; 1(8264): 170-1.
41. Ingrosso L, Pisani F, Pocchiari M. Transmission of the 263K scrapie strain by the dental route J Gen Viral 1999; 80(Pt 11):3043-7.
42. Fédération Dentaire Internationale. FDI policy statement on transmissible spongiform encephalopathies: implications for the practice of dentistry. September 2001. Available from: URL: http://www.fdiworldental.org/ federation/3_Ostatements.html.
43. Kohn WG, Collins AS, Cleveland JL, Harte JA, Eklund KJ, Malvitz DM. Guidelines for infection control in dental health-care settings - 2003. MMWR Recomm Rep 2003; 52(RR-17):1-61.