메뉴 건너뛰기




Volumn 29, Issue 5, 2006, Pages 701-717

Streamlined approach to the crude compound purification to assay process

Author keywords

Process; Purification; Streamlined approach

Indexed keywords

ASSAYS; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 33644638021     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070500509256     Document Type: Article
Times cited : (6)

References (17)
  • 1
    • 0030959257 scopus 로고    scopus 로고
    • Solution phase combinatorial chemistry-discovery of novel polyazapyridinophanes with potent antibacterial activity by a solution phase simultaneous addition of functionalities Approach
    • An, H.Y.; Cummins, L.L.; Griffey, R.H.; Bharadwai, R.; Haly, B.D.; Fraser, A.S.; Wilson-Lingardo, L.; Risen, L.M.; Wyatt, J.R.; Cook, P.D. Solution phase combinatorial chemistry-discovery of novel polyazapyridinophanes with potent antibacterial activity by a solution phase simultaneous addition of functionalities Approach. J. Am. Chem. Soc. 1997, 119, 3696-3708.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 3696-3708
    • An, H.Y.1    Cummins, L.L.2    Griffey, R.H.3    Bharadwai, R.4    Haly, B.D.5    Fraser, A.S.6    Wilson-Lingardo, L.7    Risen, L.M.8    Wyatt, J.R.9    Cook, P.D.10
  • 2
    • 0031151960 scopus 로고    scopus 로고
    • New methods in combinatorial chemistry - Robotics and parallel synthesis
    • Cargill, J.F.; Lebl, M. New methods in combinatorial chemistry - robotics and parallel synthesis. Curr. Opin. Chem. Biol. 1997, 1, 67-71.
    • (1997) Curr. Opin. Chem. Biol. , vol.1 , pp. 67-71
    • Cargill, J.F.1    Lebl, M.2
  • 3
    • 33644662862 scopus 로고    scopus 로고
    • Web alert; combinatorial chemistry
    • Czarnik, A.W. Web alert; combinatorial chemistry. Curr. Opin. Chem. Biol. 1997, 1, 1-2.
    • (1997) Curr. Opin. Chem. Biol. , vol.1 , pp. 1-2
    • Czarnik, A.W.1
  • 4
    • 0031372267 scopus 로고    scopus 로고
    • An automated system for the purification of combinatorial libraries by preparative LC/MS
    • Kibbey, C.E. An automated system for the purification of combinatorial libraries by preparative LC/MS. Lab. Rob. Autom. 1997, 9, 309-321.
    • (1997) Lab. Rob. Autom. , vol.9 , pp. 309-321
    • Kibbey, C.E.1
  • 5
    • 0001532712 scopus 로고    scopus 로고
    • Developments of a fully automated parallel HPLC/mass spectrometry system for the analytical characterization and preparative purification of combinatorial libraries
    • Zeng, L.; Kassel, D.B. Developments of a fully automated parallel HPLC/mass spectrometry system for the analytical characterization and preparative purification of combinatorial libraries. Anal. Chem. 1998, 70, 4380-4388.
    • (1998) Anal. Chem. , vol.70 , pp. 4380-4388
    • Zeng, L.1    Kassel, D.B.2
  • 6
    • 0032559294 scopus 로고    scopus 로고
    • Automated analytical/preparative high-performance liquid chromatography-mass spectrometry for the rapid characterization and purification of compound libraries
    • Zeng, L.; Burton, L.; Yung, K.; Shushan, B.; Kassel, D.B. Automated analytical/preparative high-performance liquid chromatography-mass spectrometry for the rapid characterization and purification of compound libraries. J. Chromatogr. A 1998, 794, 3-13.
    • (1998) J. Chromatogr. A , vol.794 , pp. 3-13
    • Zeng, L.1    Burton, L.2    Yung, K.3    Shushan, B.4    Kassel, D.B.5
  • 7
    • 0032082115 scopus 로고    scopus 로고
    • New developments in automated prepLCMS extends the robustness and utility of the method for compound library analysis and purification
    • Zeng, L.; Wang, X.; Wang, T.; Kassel, D.B. New developments in automated prepLCMS extends the robustness and utility of the method for compound library analysis and purification. Comb. Chem. High Throughput Screen. 1998, 1 (2), 101-111.
    • (1998) Comb. Chem. High Throughput Screen. , vol.1 , Issue.2 , pp. 101-111
    • Zeng, L.1    Wang, X.2    Wang, T.3    Kassel, D.B.4
  • 8
    • 0036646123 scopus 로고    scopus 로고
    • High-throughput mass-directed parallel purification incorporating a multiplexed single quadrupole mass spectrometer
    • Kassel, D.B.; Xu, R.; Wang, T.; Isbell, J.; Cai, Z.; Sykes, C.; Brailsford, A. High-throughput mass-directed parallel purification incorporating a multiplexed single quadrupole mass spectrometer. Anal. Chem. 2002, 74 (13), 3055-3062.
    • (2002) Anal. Chem. , vol.74 , Issue.13 , pp. 3055-3062
    • Kassel, D.B.1    Xu, R.2    Wang, T.3    Isbell, J.4    Cai, Z.5    Sykes, C.6    Brailsford, A.7
  • 9
    • 0036831328 scopus 로고    scopus 로고
    • Realities of high-throughput liquid chromatography/mass spectrometry purification of large combinatorial libraries: A report on overall sample throughput using parallel purification
    • Isbell, J.; Xu, R.; Cai, Z.; Kassel, D.B. Realities of high-throughput liquid chromatography/mass spectrometry purification of large combinatorial libraries: A report on overall sample throughput using parallel purification. J. Comb. Chem. 2002, 4 (6), 600-611.
    • (2002) J. Comb. Chem. , vol.4 , Issue.6 , pp. 600-611
    • Isbell, J.1    Xu, R.2    Cai, Z.3    Kassel, D.B.4
  • 10
    • 0345119091 scopus 로고    scopus 로고
    • Application of visual basic in high-throughput mass spectrometry-directed purification of combinatorial libraries
    • Li, B.; Chan, E.C.Y. Application of visual basic in high-throughput mass spectrometry-directed purification of combinatorial libraries. J. Comb. Chem. 2003, 5 (6), 834-841.
    • (2003) J. Comb. Chem. , vol.5 , Issue.6 , pp. 834-841
    • Li, B.1    Chan, E.C.Y.2
  • 11
    • 0141786953 scopus 로고    scopus 로고
    • Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries
    • Leister, W.; Strauss, K.; Wisnoski, D.; Zhao, Z.; Lindley, C. Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries. J. Comb. Chem. 2003, 5 (3), 322-329.
    • (2003) J. Comb. Chem. , vol.5 , Issue.3 , pp. 322-329
    • Leister, W.1    Strauss, K.2    Wisnoski, D.3    Zhao, Z.4    Lindley, C.5
  • 12
    • 10444240991 scopus 로고    scopus 로고
    • Process technologies for purity enhancement of large discovery libraries
    • Pottorf, R.S.; Player, M.R. Process technologies for purity enhancement of large discovery libraries. Curr. Opin. Drug Disc. Devel. 2004, 7 (6), 777-783.
    • (2004) Curr. Opin. Drug Disc. Devel. , vol.7 , Issue.6 , pp. 777-783
    • Pottorf, R.S.1    Player, M.R.2
  • 13
    • 9344270478 scopus 로고    scopus 로고
    • Preparative LC-MS purification: Improved compound-specific method optimization
    • Blom, K.F.; Glass, B.; Sparks, R.; Combs, A.P. Preparative LC-MS purification: Improved compound-specific method optimization. J. Comb. Chem. 2004, 6 (6), 874-883.
    • (2004) J. Comb. Chem. , vol.6 , Issue.6 , pp. 874-883
    • Blom, K.F.1    Glass, B.2    Sparks, R.3    Combs, A.P.4
  • 14
    • 0141795449 scopus 로고    scopus 로고
    • Optimizing preparative LC/MS configurations and methods for parallel synthesis purification
    • Blom, K.F.; Sparks, R.; Doughty, J.; Everlof, J.G.; Hague, T.; Combs, A.P. Optimizing preparative LC/MS configurations and methods for parallel synthesis purification. J. Comb. Chem. 2003, 5, 670-683.
    • (2003) J. Comb. Chem. , vol.5 , pp. 670-683
    • Blom, K.F.1    Sparks, R.2    Doughty, J.3    Everlof, J.G.4    Hague, T.5    Combs, A.P.6
  • 15
    • 0041335129 scopus 로고    scopus 로고
    • Parallel preparative high-performance liquid chromatography with on-line molecular mass characterization
    • Edwards, C.; Liu, J.; Smith, T.J.; Brooke, D.; Hunter, D.J.; Organ, A.; Coffey, P. Parallel preparative high-performance liquid chromatography with on-line molecular mass characterization. Rapid Comm. Mass Spectrom. 2003, 17 (18), 2027-2033.
    • (2003) Rapid Comm. Mass Spectrom. , vol.17 , Issue.18 , pp. 2027-2033
    • Edwards, C.1    Liu, J.2    Smith, T.J.3    Brooke, D.4    Hunter, D.J.5    Organ, A.6    Coffey, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.