Morphine administration and short-term pulmonary outcomes among ventilated preterm infants

Pediatrics

Volumn 116, Issue 2, 2005, Pages 352-359

  Bhandari, Vineet ^a,e   Bergqvist, Lena L ^b   Kronsberg, Shari S ^c   Barton, Bruce A ^c   Anand, Kanwaljeet J S ^d  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c MARYLAND MEDICAL RESEARCH INSTITUTE   (United States)

^d ARKANSAS CHILDREN S HOSPITAL   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bronchopulmonary dysplasia; Lung; Morphine; Newborn infant; Pain

Indexed keywords

ANALGESIC AGENT; MORPHINE; PLACEBO; SURFACTANT; NARCOTIC ANALGESIC AGENT;

ARTICLE; BIRTH WEIGHT; CHILD DEATH; CHORIOAMNIONITIS; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; DRUG TOLERANCE; DUCTUS ARTERIOSUS; GESTATIONAL AGE; HOSPITALIZATION; HUMAN; INFANT; LOGISTIC REGRESSION ANALYSIS; LUNG DYSPLASIA; LUNG FUNCTION; LUNG VENTILATION; MAJOR CLINICAL STUDY; OXYGEN THERAPY; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; BREATHING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; INTRAVENOUS DRUG ADMINISTRATION; NEONATAL RESPIRATORY DISTRESS SYNDROME; NEWBORN; PREMATURITY; RANDOMIZED CONTROLLED TRIAL;

ANALGESICS, OPIOID; BRONCHOPULMONARY DYSPLASIA; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFUSIONS, INTRAVENOUS; MORPHINE; RESPIRATION; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, NEWBORN; SEVERITY OF ILLNESS INDEX;

EID: 33644636060     PISSN: 00314005     EISSN: 00314005     Source Type: Journal    
DOI: 10.1542/peds.2004-2123     Document Type: Article

References (36)

1. Anand KJS. Clinical importance of pain and stress in preterm neonates. Biol Neonate. 1998;73:1-9
2. Kahn DJ, Richardson DK, Gray JE, et al. Variation among neonatal intensive care units in narcotic administration. Arch Pediatr Adolesc Med. 1998;152:844-851
3. Kennedy KA, Tyson JE. Narcotic analgesia for ventilated newborns: are placebo-controlled trials ethical and necessary? J Pediatr. 1999;134:127-129
4. Dyke MP, Kohan R, Evans S. Morphine increases synchronous ventilation in preterm infants. J Paediatr Child Health. 1995;31:176-179
5. Anand KJS, McIntosh N, Lagercrantz H, et al. Analgesia and sedation in preterm neonates who require ventilatory support: results from the NOPAIN trial. Arch Pediatr Adolesc Med. 1999;153:331-338
6. Orsini AJ, Leef KH, Costarino A, Dettore MD, Stefano JL. Routine use of fentanyl infusions for pain and stress reduction in infants with respiratory distress syndrome. J Pediatr. 1996;129:140-145
7. Lago P, Benini F, Agosto C, Zacchello F. Randomised controlled trial of low dose fentanyl infusion in preterm infants with hyaline membrane disease. Arch Dis Child Fetal Neonatal Ed. 1998;79:F194-F197
8. Anand KJS, Hall RW, Desai NS, et al. Effect of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomized trial. Lancet. 2004;263:1673-1682
9. Bhat R, Abu-Harb M, Chari G, Gulati A. Morphine metabolism in acutely ill preterm newborn infants. J Pediatr. 1992;120:795-799
10. Barrett DA, Barker DP, Rutter N, Pawula M, Shaw PN. Morphine, morphine-6-glucuronide and morphine-3-glucuronide pharmacokinetics in newborn infants receiving diamorphine infusions. Br J Clin Pharmacol. 1996;41:531-537
11. Barrett DA, Elias-Jones AC, Rutter N, Shaw PN, Davis SS. Morphine kinetics after diamorphine infusion in premature neonates. Br J Clin Pharmacol. 1991;32:31-37
12. Hartley R, Green M, Quinn M, Levene MI. Pharmacokinetics of morphine infusion in premature neonates. Arch Dis Child. 1993;69:55-58
13. Bhat R, Chari G, Gulati A, Aldana O, Velamati R, Bhargava H. Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life. J Pediatr. 1990;117:477-481
14. Scott CS, Riggs KW, Ling EW, et al. Morphine pharmacokinetics and pain assessment in premature newborns. J Pediatr. 1999;135:423-429
15. Zahorodny W, Rom C, Whitney W, et al. The neonatal withdrawal inventory: a simplified score of newborn withdrawal. J Dev Behav Pediatr. 1998;19:89-93
16. Cunningham N. Inclusion of the nonverbal patient: a matter of moral emergency. Pain Forum. 1999;8:110-111
17. International Neonatal Network. The CRIB (Clinical Risk Index for Babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. Lancet. 1993;342:193-198
18. Wood CM, Rushforth JA, Hartley R, Dean H, Wild J, Levene MI. Randomized double blind trial of morphine versus diamorphine for sedation of preterm infants. Arch Dis Child Fetal Neonatal Ed. 1998;79:F34-F39
19. Jacqz-Aigrain E, Daoud P, Burtin P, Desplanques L, Beaufils F. Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies. Lancet. 1994;344:646-650
20. Bhandari V, Narang A. Role of morphine or triclofos in neonatal ventilation: a pilot study [abstract]. Bull Natl Neonatol Forum. 1992;6:8-9
21. Bhandari A, Bhandari V. Pathogenesis, pathology, and pathophysiology of pulmonary sequelae of bronchopulmonary dysplasia in premature neonates. Front Biosci. 2003;8:e370-e380
22. Miller J, Law AB, Parker RA, Sundell H, Silberberg AR, Cotton RB. Effects of morphine and pancuronium on lung volume and oxygenation in premature infants with hyaline membrane disease. J Pediatr. 1994;125:97-103
23. Alexander SM, Todres ID. The use of sedation and muscle relaxation in the ventilated infant. Clin Perinatol. 1998;25:63-78
24. Ng E, Taddio A, Ohlsson A. Intravenous midazolam infusion for the sedation of infants in the neonatal intensive care unit. Cochrane Database Syst Rev. 2000;(2):CD002052
25. Simons SH, van Dijk M, van Lingen RA, et al. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. JAMA. 2003;290:2419-2427
26. Quinn MW, Vokes A. Effect of morphine on respiratory drive in trigger ventilated pre-term infants. Early Hum Dev. 2000;59:27-35
27. Corrupt PA, Testa A, Bechalany A, El Tayar N, Descas P, Perrisoud D. Metabolites of morphine as molecular chameleons. J Med Chem. 1991;34:1272-1275
28. Christrup LL. Morphine metabolites. Acta Anaesth Scand. 1997;41:116-122
29. Osborne RJ, Joel SP, Trew D, Slevin M. Analgesic activity of morphine-6-glucuronide. Lancet. 1988;1:828
30. Inturrisi CE. Morphine-6-glucuronide: a potent μ-agonist. Life Sci. 1987;41:2845-2849
31. Suzuki N, Kalso E, Rosenberg PH. Intrathecal morphine-3-glucuronide does not antagonise spinal anti-nociception by morphine or morphine-6-glucuronide in rats. Eur J Pharmacol. 1993;249:247-250
32. Smith MT, Watt JA, Cramond T. Morphine-3-glucuronide: a potent antagonist of morphine analgesia. Life Sci. 1990;47:579
33. Bouwmeester NJ, van den Anker JN, Hop WC, Anand KJ, Tibboel D. Age- and therapy-related effects on morphine requirements and plasma concentrations of morphine and its metabolites in postoperative infants. Br J Anaesth. 2003;90:642-652
34. Bouwmeester NJ, Hop WC, van Dijk M, Anand KJ, van den Anker JN, Tibboel D. Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism. Intensive Care Med. 2003;29:2009-2015
35. Kaaresen PI, Dùhlen G, Fundingsrud HP, Dahl LB. The use of CRIB (Clinical Risk Index for Babies) score in auditing the performance of one neonatal intensive care unit. Acta Paediatr. 1998;87:195-200
36. Rautonen J, Mäkelá A, Boyd H, Apajasalo M, Pohjavuori M. CRIB and SNAP: assessing the risk of death for preterm infants. Lancet. 1994;343:1272-1273