Biopharmaceutic and pharmacokinetic studies following the oral administration of sodium salicylate in oily and aqueous vehicles to rabbit

International Journal of Pharmaceutics

Volumn 311, Issue 1-2, 2006, Pages 63-68

  Alhamami, Omran M O ^a   Aljanabi, Najah H ^b   Shalan, Naeem M ^a  

^a AL AHLIYYA AMMAN UNIVERSITY   (Jordan)

^b UNIVERSITY OF KUFA   (Iraq)

Author keywords

Absorption rate constant (ka); Area under the curve (AUC); Drug clearance (clt); Elimination rate constant (k); Fractionated coconut oil (FCO); Gastric emptying rate (GER); Volume of distribution ( d)

Indexed keywords

COCONUT OIL; GLYCEROL; SALICYLATE SODIUM;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG FORMULATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; GASTRIC EMPTYING; GASTROINTESTINAL TRANSIT; GLYCEROL; INTESTINAL ABSORPTION; MALE; PLANT OILS; RABBITS; SODIUM SALICYLATE; VEHICLES; VISCOSITY; WATER;

EID: 33644620709     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.12.011     Document Type: Article

References (32)

1. Alhamami, O.M.O., 1981. Bioavailability Studies on Orally Administered, Oily Suspensions of Drugs. Ph.D. Thesis. School of Pharmacy, Leicester Polytechnic (De Montrfort University now), Leicester, England, pp. 51-60.
2. O.M.O. Alhamami Effects of oily vehicles on the bioavailability of orally administered, sodium salicylate in rabbit Albalqa' J. Res. Stud. 9 2 2002 73 85
3. O.M.O. Alhamami Effect of gastrointestinal transit on the bioavailability of orally administered drugs in rabbit Arab J. Pharm. Sci. 2 5 2003 73 81
4. O.M.O. Alhamami, and J.H. Richards Bioavailability studies on an orally administered, oily suspension of a water soluble drug Pharm. Acta Helv. 58 1983 237 240
5. O.M.O. Alhamami, and J.H. Richards Effects of excipients on the bioavailability of sodium salicylate from orally administered, oily suspensions Pharm. Acta Helv. 71 1996 297 303
6. K. Baert, and P. De Backer Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens J. Vet. Pharmacol. Ther. 25 6 2002 449 453
7. K. Baert, and P. De Backer Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 134 1 2003 25 33
8. K. Baert, S. Croubles, A. Maes, U. Hillaert, S. Van Calenbergh, and P. De Back Comparative metabolic excretion profile of sodium salicylate in broiler chickens and homing pigeons J. Vet. Pharmacol. Ther. 27 2 2004 123 127
9. M. Barzegar-Jalali, and J.H. Richards The effects of various suspending agents on the bioavailabilities of aspirin and salicylic acid in the rabbit Int. J. Pharm. 3 1979 133 141
10. L.Z. Benet Biopharmaceutics as a basis for the design of drug products E.J. Ariens Drug Design vol. IV 1973 Academic Press London 26 (Chapter 1)
11. S. Borgstrom, and M. Arborelius Jr. The influence of a fatty acid on duodenal motility Scand. J. Gastroint. 10 6 1975 599 601
12. D. Dubovska, V.K. Piotrovskij, M. Gajdos, Z. Krivosikova, V. Spustova, and T. Trnovec Pharmacokinetics of acetyl salicylic acid and its metabolites at low doses: a compartmental modeling Methods Find. Exp. Clin. Pharmacol. 17 1 1995 67 77
13. J.N. Hunt, and M.T. Knox Relationship between the chain length of fatty acids and the slowing of gastric emptying J. Physiol. 194 1968 327 336
14. H. Juarez Olguin, J. Flores Perez, I. Lares Asseff, A. Loredo Abdala, and L. Carbajal Rodriguez Comparative pharmacokinetics of acetyl salicylic acid and its metabolites in children suffering from autoimmune diseases Biopharm. Drug Dispos. 25 1 2004 1 7
15. I. Lares-Asseff, J. Flores-Perez, H. Juarez-Olguin, N. Ramirez-Lacayo, and A. Loredo-Abdala Influence of nutritional status on the pharmacokinetics of acetyl salicylic acid and its metabolites in children with autoimmune disease Am. J. Clin. Nutr. 69 2 1999 318 324
16. I. Lares-Asseff, H. Juarez-Olguin, J. Flores-Perez, A. Guille-Perez, and A. Vargas Pharmacokinetics and metabolic rates of acetyl salicylic acid and its metabolites in an Otomi ethnic group of Mexico Biol. Pharm. Bull. 27 5 2004 706 709
17. G. Levy Comparison of dissolution and absorption rates of different commercial aspirin tablets J. Pharm. Sci. 50 1961 388 392
18. Lin, S.L., Pramoda, M.K., 1978. Permanent suspension pharmaceutical dosage form. U.S. Pat. Spec. No. 1,505,764.
19. G. Lolli, and R. Smith Effervescent mixtures as adjuvant to the rapid absorption of ingested drugs New Engl. J. Med. 235 1964 80 84
20. R.K. Nayak, and L.Z. Benet Use of unanesthetized rhesus monkey as a model for studying the gastrointestinal absorption of drugs J. Pharmacokinet. Biopharm. 2 1974 417 431
21. S.J. Preston, M.H. Arnold, E.M. Beller, P.M. Brooks, and W.W. Buchanan Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetyl salicylic acid (aspirin) in rheumatoid arthritis Br. J. Clin. Pharmacol. 27 5 1989 607 611
22. Robert, W.M., 1931. Bioavailability Studies on Orally Administered, Oily Suspensions of Drugs. Ph.D. Thesis. School of Pharmacy, Leicester Polytechnic (De Montrfort University now), Leicester, England, pp. 51-60.
23. Quart. J. Med. 24, 133-152 (Quoted from Alhamami, O.M.O., 1981).
24. M.L. Salim, and O.M.O. Alhamami Regulation of gastric emptying rate and intestinal transit affect significantly the rate and extent of drug absorption Alexandria J. Pharm. Sci. 17 2 2003 159 171
25. A.J.M. Schoonen, F. Moolenaar, C. Haverschmidt, and T. Huizinga The interphase transport of drugs from fatty suppository bases Pharm. Weekblad III 1976 585 589
26. C.R. Short, C.A. Neff-Davis, L.C. Hsieh, G.D. Koritz, M.S. Malbrough, S.A. Barker, and L.E. Davis Pharmacokinetics and elimination of salicylic acid in rabbits J. Vet. Pharmacol. Ther. 14 1 1991 70 77
27. P. Sleight Speed of action of aspirin, soluble aspirin and buffered aspirin Lancet 1 1960 305 307
28. Stephens, V.C., Su, K.S.E., 1975. Non-aqueous vehicle for oral pharmaceutical suspensions. US Patent 3,920,819.
29. P. Trinder Rapid determination of salicylates in body fluids Biochem. J. 57 1954 301 303
30. E.B. Truitt Jr., and A.M. Morgan Gastrointestinal factors in aspirin absorption. A quantitative study J. Pharm. Sci. 53 1964 129 134
31. J.G. Wagner Fundamental of clinical pharmacokinetics 1st ed., 2nd printing 1979 Drug Intell. Pub. Inc. Hamilton, Illinois 300-301, Chapter 8
32. M. Watanabe, T. Ozeki, T. Shibata, H. Murakoshi, Y. Takashima, H. Yuasa, and H. Okada Effect of shape of sodium salicylate particles on physical property and in vitro aerosol performance of granules prepared by pressure swing granulation method AAPS Pharm. Sci. Technol. 4 4 2003 E64