Don't give up on erythropoietin as a neuroprotective agent [16]

Pediatrics

Volumn 116, Issue 2, 2005, Pages 521-522

  Dame, Christof ^a   Fahnenstich, Hubert ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Department of Pediatrics   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; NEUROPROTECTIVE AGENT; RECOMBINANT ERYTHROPOIETIN; IRON;

BLOOD BRAIN BARRIER; BRAIN INJURY; BRAIN ISCHEMIA; CLINICAL TRIAL; DRUG SAFETY; EXTREMELY LOW BIRTH WEIGHT; HUMAN; LETTER; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; CHILD DEVELOPMENT; GROWTH, DEVELOPMENT AND AGING; INFANT; NEWBORN; NOTE; VERY LOW BIRTH WEIGHT;

CHILD DEVELOPMENT; ERYTHROPOIETIN, RECOMBINANT; HUMANS; INFANT; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; IRON; NEUROPROTECTIVE AGENTS;

EID: 33644613363     PISSN: 00314005     EISSN: 00314005     Source Type: Journal    
DOI: 10.1542/peds.2005-0637     Document Type: Letter

References (16)

1. Ohls RK, Ehrenkranz RA, Das A, et al. Neurodevelopmental outcome and growth at 18 to 22 months' corrected age in extremely low birth weight infants treated with early erythropoietin and iron. Pediatrics. 2004;114:1287-1291
2. Dame C, Juul SE, Christensen RD. The biology of erythropoietin in the central nervous system and its neurotrophic and neuroprotective potential. Biol Neonate. 2001;79:228-235
3. Maiese K, Li F, Chong ZZ. New avenues of exploration for erythropoietin. JAMA. 2005;293:90-95
4. Ehrenreich H, Hasselblatt M, Dembowski C, et al. Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med. 2002;8:495-505
5. Siren AL, Knerlich F, Poser W, Gleiter CH, Bruck W, Ehrenreich H. Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain. Acta Neuropathol (Berl). 2001;101:271-276
6. Juul SE, Yachnis AT, Rojiani AM, Christensen RD. Immunohistochemical localization of erythropoietin and its receptor in the developing human brain. Pediatr Dev Pathol. 1999;2:148-158
7. Knabe W, Knerlich F, Washausen S, et al. Expression patterns of erythropoietin and its receptor in the developing midbrain. Anat Embryol (Berl). 2004;207:503-512
8. Chin K, Yu X, Beleslin-Cokic B, et al. Production and processing of erythropoietin receptor transcripts in brain. Mol Brain Res. 2000;81:29-42
9. Spandou E, Papoutsopoulou S, Soubasi V, et al. Hypoxia-ischemia affects erythropoietin and erythropoietin receptor expression pattern in the neonatal rat brain. Brain Res. 2004;1021:167-172
10. Dame C, Bartmann P, Wolber E, Fahnenstich H, Hofmann D, Fandrey J. Erythropoietin gene expression in different areas of the developing human central nervous system. Dev Brain Res. 2000;125:69-74
11. Chikuma M, Masuda S, Kobayashi T, Nagao M, Sasaki R. Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus. Am J Physiol Endocrinol Metab. 2000;279:E1242-E1248
12. Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA. 2000;97:10526-10531
13. Wang L, Zhang Z, Wang Y, Zhang R, Chopp M. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke. 2004;35:1732-1737
14. Juul SE, Harcum J, Li Y, Christensen RD. Erythropoietin is present in the cerebrospinal fluid of neonates. J Pediatr. 1997;130:428-430
15. Juul SE, McPherson RJ, Farrell FX, Jolliffe L, Ness DJ, Gleason CA. Erytropoietin concentrations in cerebrospinal fluid of nonhuman primates and fetal sheep following high-dose recombinant erythropoietin. Biol Neonate. 2004;85:138-144
16. Buhrer C, Obladen M, Maier R, Muller C. Urinary losses of recombinant erythropoietin in preterm infants. J Pediatr. 2003;142:452-453