Double-stranded RNA-dependent protein kinase (PKR) is a stress-responsive kinase that induces NFκB-mediated resistance against mercury cytotoxicity

Life Sciences

Volumn 78, Issue 16, 2006, Pages 1845-1856

  Frémont, Marc ^a   Vaeyens, Freya ^a   Herst, C Vincent ^a   De Meirleir, Kenny L ^b   Englebienne, Patrick ^a,c  

^a R E D LABORATORIES   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Cellular stress; Mercury toxicity; PKR; Resistance; ROS; Type I interferons

Indexed keywords

2 AMINOPURINE; BETA INTERFERON; CELL PROTEIN; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MERCURY; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE INHIBITOR; PROTEIN KINASE R; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN;

ARTICLE; BURKITT LYMPHOMA; CELL FUNCTION; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MODEL; MYELOID LEUKEMIA; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SENSITIVITY ANALYSIS; STRESS; T LYMPHOCYTE;

2-AMINOPURINE; B-LYMPHOCYTES; CELLS, CULTURED; DRUG RESISTANCE; EIF-2 KINASE; FLOW CYTOMETRY; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INTERFERON-BETA; LYMPHOMA, B-CELL; MERCURY; NF-KAPPA B; OXIDATIVE STRESS; POLY I-C; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES;

EUKARYOTA;

EID: 33644551572     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.08.024     Document Type: Article

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