Effect of immunosuppressive doses of cyclosporine on pancreatic beta cell function in pigs

American Journal of Veterinary Research

Volumn 63, Issue 11, 2002, Pages 1501-1506

  Dean, Sophia K ^a   Scott, Hayley ^a   Keogh, Gregory W ^a   Roberts, Simon ^a   Tuch, Bernard E ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ARGININE; BILIRUBIN; C PEPTIDE; CREATININE; CYCLOSPORIN; GLUCAGON; GLUCOSE; INSULIN; SERUM ALBUMIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; CELL FUNCTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INSULIN BLOOD LEVEL; INTRAVENOUS GLUCOSE TOLERANCE TEST; KIDNEY FUNCTION; LIVER FUNCTION; METABOLIC CLEARANCE RATE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; SWINE;

ANIMALIA; PIERIS BRASSICAE; SUIDAE; SUS SCROFA;

EID: 0036845419     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2002.63.1501     Document Type: Article

References (30)

1. Dorling A, Riesbeck K, Warrens A, et al. Clinical xenotransplantation of solid organs. Lancet 1997;349:867-871.
2. Groth CG, Korsgren O, Tibell A, et al. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 1994;344:1402-1404.
3. Korsgren O, Jansson L, Eizirik D, et al. Functional and morphological differentiation of fetal porcine islet-like cell clusters after transplantation into nude mice. Diabetologia 1991;34:379-386.
4. Liu X, Federlin KF, Bretzel RG, et al. Persistent reversal of diabetes by transplantation of fetal pig proislets into nude mice. Diabetes 1991;40:858-866.
5. Simeonovic CJ, Ceredig R, Wilson JD. Effect of GK1.5 monoclonal antibody dosage on survival of pig proislet xenografts in CD4+ T cell-dependent mice. Transplantation 1990;49:849-856.
6. Tuch BE, Wright DC, Martin TE, et al. Differentiation of fetal pig endocrine cells after allografting into the thymus gland. Transplantation 1999;67:1184-1187.
7. Vo L, Tuch BE, Wright DC, et al. Lowering of blood glucose to non-diabetic levels in a hyperglycemic pig by allografting of fetal pig islet-like cell clusters. Transplantation 2001;71:1671-1677.
8. Rubin AM, Kang H. Cerebral blindness and encephalopathy with cyclosporin A toxicity. Neurology 1987;37:1072-1076.
9. Canadian Multicentre Transplant Study Group. A randomised clinical trial of cyclosporine in cadaveric renal transplantation. N Engl J Med 1983;309:809-815.
10. Bennett WM, Porter GA. Cyclosporin-associated hypertension. Am J Med 1988;85:131-133.
11. Merion RM, White DJG, Thiru S, et al. Cyclosporine: five years' experience in cadaveric renal transplantation. N Engl J Med 1984;310:148-154.
12. Beaman M, Parvin S, Veitch PS, et al. Convulsions associated with cyclosporin A in renal transplant recipients. Br Med J 1985; 290:139-140.
13. Tugwell P, Bennett KJ, Chalmers A, et al. Lose-dose cyclosporin versus placebo in patients with rheumatoid arthritis. Lancet 1991;335:1051-1055.
14. Parving H, Tarnow L, Nielsen FS, et al. Cyclosporine nephrotoxicity in type 1 diabetic patient. Diabetes Care 1999;22:478-483.
15. Hahn HJ, Lucke LS, Klöting I, et al Toxic effects of cyclosporin on endocrine pancreas of Wistar rats. Transplantation 1986;41:44-47.
16. Sabbatini M, Sansome G, Ucello E et al. Acute effects of rapamycin on glomerular dynamics. Transplantation 2000;69: 1946-1950.
17. Vaden SL, Riviere JE. Pharmacokinetics, inhibition of lymphoblast transformation, and toxicity of cyclosporine in clinically normal pigs. Am J Vet Res 1990;51:399-403.
18. Hausen B, Ikonen T, Briffa N, et al. Combined immunosuppression with cyclosporine (Neoral) and SDZ RAD in non-human primate lung transplantation: systemic pharmokinetic-based trials to improve efficacy and tolerability Transplantation 2000;69:76-86.
19. Formby B, Miller N, Garret R, et al. Effects of low-dose cyclosporine prophylaxis in non-obese diabetic mice. J Pharm Exp Ther 1987;241:1106-1111.
20. Anderson A, Borg H, Hellerström C, et al. Long-term effects of cyclosporin A on cultures mouse pancreatic islets. Diabetologia 1984;27:66-69.
21. Gillison SL, Bartlett ST, Curry DL. Inhibition by cyclosporine of insulin secretion-a beta cell-specific alteration of islet tissue function. Transplantation 1991;52:890-895.
22. Bani-Sacchi T, Bani D, Filipponi F, et al. Immunocytochemical and ultrastructural changes of islet cells in rats treated long-term with cyclosporin at immunotherapeutic doses. Transplantation 1990;49:982-987.
23. Garwin PJ, Nichoff M, Staggenborg J. Cyclosporin's effect on canine pancreatic endocrine function. Transplantation 1988; 45:1027-1031.
24. Alejando R, Feldman EC, Bloom AD, et al. Effects of cyclosporin on insulin and C-peptide secretion in healthy beagles. Diabetes 1989;38:698-703.
25. Van Schilfgaarde R, Van Der Burg MP Van Suylichem PT, et al. Interference by cyclosporine with the endocrine function of canine pancreas. Transplantation 1987;44:13-16.
26. Borel JF, Feurer C, Glubler HU, et al. Biological effects of cyclosporin A: a new anti-lymphocytic agent. Agents Actions 1976; 6:468-475.
27. Borel JF, Feurer C, Magnee C, et al. Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology 1977;32:1017-1025.
28. Cohen O, Einav Y, Cohen Y, et al. Implantation of rat insulinoma cell line into cyclosporine treated rats. Effect of the in vivo environment of beta cell specific gene expression. Transplantation 2000;69:1464-1470.
29. Mellert J, Hering BJ, Liu X, et al. Successful islet auto- and allotransplantation in diabetic pigs. Transplantation 1998;66:200-204.
30. Tuch BE, Viketos S, Grigoriou S, et al. Lack of toxicity of Cyclosporin A on human fetal pancreas. Transplant Proc 1987;19: 1257-258.