Effects of trifluoroacetic acid concentrations in mobile phases on HPLC retention of zwitterionic and weakly basic triazole derivatives

Journal of Liquid Chromatography and Related Technologies

Volumn 29, Issue 3, 2006, Pages 415-430

  Guan, Kailin ^a   Palmer, David C ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

1,2,4 Triazoles; Chaotropic effect; Elution order; Retention time shift; Solvation; TFA concentration; Trifluoroacetic acid (TFA); Zwitterions

Indexed keywords

AMINES; AROMATIC COMPOUNDS; CARBOXYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; PHOSPHORIC ACID;

1,2,4-TRIAZOLES; CHAOTROPIC EFFECT; ELUTION ORDER; RETENTION TIME SHIFT; SOLVATION; TFA CONCENTRATION; TRIFLUOROACETIC ACID (TFA); ZWITTERIONS;

ACETIC ACID;

1,2,4 TRIAZOLE DERIVATIVE; ACETIC ACID; AMPHOLYTE; FORMIC ACID; PHOSPHORIC ACID; TRIETHYLAMINE; TRIFLUOROACETIC ACID;

ACIDITY; ARTICLE; COLUMN CHROMATOGRAPHY; DECARBOXYLATION; ELUTION; HYDROPHOBICITY; OBSERVATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 33644546066     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1080/10826070500452077     Document Type: Article

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