HBsAg loading on dendritic cells in patients with chronic hepatitis B: Expressions of phenotypic molecules

Hepatobiliary and Pancreatic Diseases International

Volumn 5, Issue 1, 2006, Pages 56-59

  Tong, Hua Sheng ^a   Zhang, Yi ^b   Yuan, Keng ^c   Fu, Xin Wen ^d  

^a FIRST MILITARY MEDICAL UNIVERSITY   (China)

^b JIANGXI MEDICAL COLLEGE   (China)

^c Key Oncology Laboratory   (China)

^d Cancer Hospital of Jiangxi Province   (China)

Author keywords

Antigen presenting; Chronic hepatitis B; Dendritic cells; Immune response; Phenotypic molecules

Indexed keywords

B7 ANTIGEN; CD83 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; ELECTRON MICROSCOPY; FEMALE; FLOW CYTOMETRY; HEPATITIS B; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; STATISTICAL SIGNIFICANCE; UPREGULATION; VIRUS IMMUNITY;

ADOLESCENT; ADULT; ANTIGENS, CD; ANTIGENS, CD80; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; IMMUNOGLOBULINS; MALE; MEMBRANE GLYCOPROTEINS; MICROSCOPY, ELECTRON; MIDDLE AGED; PHENOTYPE; RETROSPECTIVE STUDIES;

EID: 33644527902     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Guidotti LG. The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection. Vaccine 2002; Suppl 4:A80-82.
2. Jung MC, Pape GR. Immunology of hepatitis B infection. Lancet Infect Dis 2002;1:43-50.
3. O'Neill D, Bhardwaj N. Exploiting dendritic cells for active immunotherapy of cancer and chronic infection. Methods Mol Med 2005;109:1-18.
4. Gowans EJ, Jones KL, Bharadwaj M, Jackson DC. Prospects for dendritic cell vaccination in persistent infection with hepatitis C virus. J Clin Virol 2004;4:283-290.
5. Tavakoli S, Schwerin W, Rohwer A, Hoffmann S, Weyer S, Weth R, et al. Phenotype and function of monocyte derived dendritic cells in chronic hepatitis B virus infection. J Gen Virol 2004;85(Pt 10) :2829-2836.
6. van der Molen RG, Sprengers D, Binda RS, de Jong EC, Niesters HG, Kusters JG, et al. Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B. Hepatology 2004;3:738-746.
7. Xing LH, Wang FS, Liu MX, Zhu CL, Li HW, Lei ZY, et al. Property and implication of dendritic cells from peripheral blood monocytes in patients with persistent hepatitis B virus infection. Chin J Infect Dis 2001;19:348-351.
8. Xiong YL, Liu GZ, Jia YZ. Mechanism of immune tolerance with chronic hepatitis B virus infection in hepatitis B virus transgenic mice. World Chin J Digestol 2002;6:642-645.
9. Zhou YQ, Zhan J, Den XL, Zhi H, Wei J, Huang ZM. Study of CD40 and CD80 on peripheral blood dentritic cells in patients with chronic hepatitis B in vitro. Chin J Immunol 2002;18:639-642.
10. Liu SR, Zhang Y, Li ZL, Yu ZY, Lu HM. The changes in morphology, epitope and function of dentritic cells isolated from patients with chronic hepatitis B. J Cell Mol Immunolo 2001;5:437-439.
11. Zheng BJ, Zhou J, Qu D, Siu KL, Lam TW, Lo HY, et al. Selective functional deficit in dendritic cell--T cell interaction is a crucial mechanism in chronic hepatitis B virus infection. J Viral Hepat 2004;3:217-224.
12. Pilon-Thomas SA, Verhaegen ME, Mule JJ. Dendritic cell-based therapeutics for breast cancer. Breast Dis 2004; 20: 65-71.
13. Brossart P, Wirths S, Stuhler G, Reichardt VL, Kanz L, Bragger W. Induction of cytotoxic T-lymphocyte responsesion in vivo after vaccinations with peptide-pulsed dentritic cells. Blood 2000;9:3102-3108.
14. Scheme of viral hepatitis prevention and therapy. Chin J Infect Dis 2001;1:56-62.
15. Romani N, Gruner S, Brang D, Kampgen E, Lenz A, Trockenbacher B, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994;180:83-93.
16. O'Neill DW, Adams S, Bhardwaj N. Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood 2004;8:2235-2246.
17. Walsh SR, Bhardwaj N, Gahdhi RT. Antigen presentation and the role of dendritic cells in HIV. Curr Opin Infect Dis 2004;1:1-6.
18. Milich DR, Leroux-Roels GG. Immunogenetics of the response to HBsAg vaccination. Autoimmun Rev 2003; 5:248-257.
19. Osorio JE, Zuleger CL, Burger M, Chu Q, Payne LG, Chen D. Immune responses to hepatitis B surface antigen following epidermal powder immunization. Immunol Cell Biol 2003;1:52-58.
20. Bohm W, Schirmbeck R, Elbe A, Melber K, Diminky D, Kraal G, et al. Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC Class I-restricted cytotoxic T lymphocytes in vivo. J Immunol 1995;155:3313-3321.
21. Oka Y, Akbar SMF, Horiike N, Joko K, Onji M. Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice. Immunol 2001;103:90-97.
22. Becker Y. Immunological and regulatory functions of uninfected and virus infected immature and mature subtypes of dendritic cells--a review. Virus Genes 2003;2:119-130.
23. Li YG, Luo YP, Liang ZW, Ren H. Antigen presenting role of dentritic cell proliferated from peripheral blood monocytes in patients with chronic hepatitis B. Chin J Hepatol 2000; 8: 330-331.
24. Rouard H, Leon A, Klonjkowski B, Marquet J, Tenneze L, Plonquet A. Adenoviral transduction of human "clinical grade" immature dendritic cells enhances costimulatory molecule expression and T-cell stimulatory capacity. Immunol 2000;241:69-81.