Whole-brain radiotherapy with or without efaproxiral for the treatment of brain metastases: Determinants of response and its prognostic value for subsequent survival

International Journal of Radiation Oncology Biology Physics

Volumn 64, Issue 4, 2006, Pages 1023-1030

  Stea, Baldassarre ^a,e   Suh, John H ^b   Boyd, Adam P ^c   Cagnoni, Pablo J ^c   Shaw, Edward ^d  

^a UNIVERSITY OF ARIZONA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c Allos Therapeutics Inc   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Brain metastases; Efaproxiral; Radiation therapy; Response; Survival

Indexed keywords

BRAIN; HEMOGLOBIN; OXYGEN; PATIENT TREATMENT; REGRESSION ANALYSIS;

BRAIN METASTASES; EFAPROXIRAL; RESPONSE; SURVIVAL;

RADIOTHERAPY;

EFAPROXIRAL; EFAPROXYN; HEMOGLOBIN; OXYGEN;

ADULT; AGED; ARTICLE; BINDING AFFINITY; BRAIN METASTASIS; BRAIN RADIATION; CANCER LOCALIZATION; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FOLLOW UP; HUMAN; IMAGE ANALYSIS; KARNOFSKY PERFORMANCE STATUS; LIVER METASTASIS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; OXYGEN AFFINITY; OXYGENATION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RADIOSENSITIVITY; TREATMENT RESPONSE;

AGED; ANALYSIS OF VARIANCE; ANILINE COMPOUNDS; BRAIN NEOPLASMS; CRANIAL IRRADIATION; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; OXYGEN; PROPIONIC ACIDS; RADIATION-SENSITIZING AGENTS; TREATMENT OUTCOME;

EID: 33644520906     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2005.10.004     Document Type: Article

References (27)

1. M. Chatani, T. Teshima, K. Hata A clinical investigation Whole brain irradiation for metastases from lung carcinoma Acta Radiol Oncol 24 1985 311 314
2. K.J. Murray, C. Scott, H.M. Greenberg A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases A report of the Radiation Therapy Oncology Group (RTOG) 9104 Int J Radiat Oncol Biol Phys 39 1997 571 574
3. L. Gaspar, C. Scott, M. Rotman Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 37 1997 745 751
4. M.P. Mehta, P. Rodrigus, C.H. Terhaard Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases J Clin Oncol 21 2003 2529 2536
5. M.K. Safo, C.M. Moure, J.C. Burnett High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector Protein Sci 10 2001 951 957
6. F.C. Wireko, G.E. Kellogg, D.J. Abraham Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction analysis of novel hemoglobin oxygen effectors J Med Chem 34 1991 758 767
7. O. Eichelbronner, A. Sielenkamper, M. D'Almeida Effects of FI(O(2)) on hemodynamic responses and O(2) transport during RSR13-induced reduction in P(50) Am J Physiol 277 1999 290 298
8. R.P. Steffen Effect of RSR13 on temperature-dependent changes in hemoglobin oxygen affinity of human whole blood A.G. Hudetz D.F. Bruley Oxygen transport to tissue XX 1998 Plenum Press New York 653 661
9. S.R. Khandelwal, R.S. Randad, P.S. Lin Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation Am J Physiol 265 1993 1450 1453
10. R.S. Randad, M.A. Mahran, A.S. Mehanna Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents J Med Chem 34 1991 752 757
11. J.C. Watson, E.M. Doppenberg, M.R. Bullock Effects of the allosteric modification of hemoglobin on brain oxygen and infarct size in a feline model of stroke Stroke 28 1997 1624 1630
12. G.P. Amorino, H. Lee, G.E. Holburn Enhancement of tumor oxygenation and radiation response by the allosteric effector of hemoglobin, RSR13 Radiat Res 156 2001 294 300
13. B.A. Teicher, G. Ara, Y. Emi RSR13 Effects on tumor oxygenation and response to therapy Drug Dev Res 38 1996 1 11
14. E. Shaw, C. Scott, J. Suh RSR13 plus cranial radiation therapy in patients with brain metastases Comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database J Clin Oncol 21 2003 2364 2371
15. F.J. Lagerwaard, P.C. Levendag, P.J. Nowak Identification of prognostic factors in patients with brain metastases A review of 1292 patients Int J Radiat Oncol Biol Phys 43 1999 795 803
16. J.H. Suh, B. Stea, A. Nabid Results from a phase III study evaluating efaproxiral as an adjunct to whole brain radiation therapy for the treatment of patients with brain metastases J Clin Oncol 24 2006 106 114
17. P. Therasse, S.G. Arbuck, E.A. Eisenhauer European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada New guidelines to evaluate the response to treatment in solid tumors J Natl Cancer Inst 92 2000 205 216
18. J.L. Fleiss Statistical methods for rates and proportions 2nd ed. 1981 John Wiley & Sons New York
19. M. Buyse, P. Piedbois On the relationship between response to treatment and survival time Stat Med 15 1996 2797 2812
20. D. Tu, K. Shalay, J. Pater Adjustment of treatment effect for covariates in clinical trials Statistical and regulatory issues Drug Information J 34 2000 511 523
21. A.B. Miller, B. Hoogstraten, M. Staquet Reporting results of cancer treatment Cancer 47 1981 207 214
22. J.O. Park, S.I. Lee, S.Y. Song Measuring response in solid tumors Comparison of RECIST and WHO response criteria Jpn J Clin Oncol 33 2003 533 537
23. A.H. Dachman, P.M. MacEneaney, A. Adedipe Tumor size on computed tomography scans Is one measurement enough? Cancer 91 2001 555 560
24. K.E. Warren, N. Patronas, A.A. Aiken Comparison of one-, two-, and three-dimensional measurements of childhood brain tumors J Natl Cancer Inst 93 2001 1401 1405
25. C. Nieder, U. Nestle, K. Walter Dose/effect relationships for brain metastases J Cancer Res Clin Onc 124 1998 346 350
26. J.R. Anderson, K.C. Cain, R.D. Gelber Analysis of survival by tumor response J Clin Oncol 1 1983 710 719
27. D.Y. Lin, T.R. Fleming, V. De Gruttola Estimating the proportion of treatment effect explained by a surrogate marker Stat Med 16 1997 1515 1527