High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector

Protein Science

Volumn 10, Issue 5, 2001, Pages 951-957

  Safo, M K ^a   Moure, C M ^a   Burnett, J C ^a   Joshi, G S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Allosteric effector; Hemoglobin; Oxygen delivery

Indexed keywords

DEOXYHEMOGLOBIN; EFAPROXIRAL;

ALLOSTERISM; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; HYDROGEN BOND; OXYGEN AFFINITY; OXYGEN TRANSPORT; PRIORITY JOURNAL;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANILINE COMPOUNDS; ANTISICKLING AGENTS; CLINICAL TRIALS, PHASE III; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HEMOGLOBINS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; PROPIONIC ACIDS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 0035055934     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.50601     Document Type: Article

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