Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction

Cardiovascular Drugs and Therapy

Volumn 18, Issue 1, 2004, Pages 13-22

  Horinaka, Shigeo ^a   Kobayashi, Naohiko ^a   Yabe, Akihisa ^a   Asakawa, Hiroshi ^a   Yagi, Hiroshi ^a   Mori, Yousuke ^a   Tsubokou, Yusuke ^a   Yoshida, Koutarou ^a   Nakano, Shigefumi ^a   Matsuoka, Hiroaki ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Adenosine triphosphate sensitive potassium channel; Arrhythmia; Endothelial nitric oxide; Myocardial infarction; Nicorandil

Indexed keywords

ADENOSINE TRIPHOSPHATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NICORANDIL; NITRIC OXIDE; POTASSIUM CHANNEL; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR 2; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RISK; CONCENTRATION (PARAMETERS); CONSCIOUSNESS; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG MECHANISM; DRUG SCREENING; ELECTROCARDIOGRAPHY; ENDOTHELIUM; EVALUATION; HEART LEFT VENTRICLE; HEART MUSCLE; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; IMMUNOHISTOCHEMISTRY; ISCHEMIC HEART DISEASE; LETHALITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SURVIVAL RATE; TIME; UPREGULATION;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; ATP-BINDING CASSETTE TRANSPORTERS; HEART VENTRICLES; MALE; MYOCARDIAL INFARCTION; NICORANDIL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; POLYMERASE CHAIN REACTION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; RNA, MESSENGER; UP-REGULATION;

EID: 3342913890     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:CARD.0000025751.82774.a9     Document Type: Article

References (32)

1. Taira N. Nicorandil as a hybrid between nitrates and potassium channel activators. Am J Cardiol 1989;63:18J-24J.
2. Holzmann S. Cyclic GMP as possible mediator of coronary arterial relaxation by Nicorandil (SG-75). J Cardiovasc Pharmacol 1983;5:364-370.
3. Grover GJ. Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion. Can J Physiol Pharmacol 1997;75:309-315.
4. ATP channel in rabbits. Int J Cardiol 1997;62:181-190.
5. Schultz JE, Yao Z, Cavero I, et al. Glibenclamide-induced blockade of ischemic preconditioning is time dependent in intact rat heart. Am J Physiol 1997;272:H2607-H2615.
6. Nakae I, Quan L, Hashimoto K, et al. Mechanism of the vasodilatory action of nicorandil on coronary circulation in dog. Cardiovasc Drug Ther 1994;8:137-145.
7. Ashikawa K, Komaru T, Sekiguchi N, et al. Evaluation of coronary microcirculation in the beating canine left ventricle. J Jpn Coll Angiol 1989;29:337-341.
8. Di Diego JM, Antzelevitch C. Pinacidil-induced electrical heterogeneity and extrasystolic activity in canine ventricular tissues. Does activation of ATP-regulated potassium current promote phase 2 reentry? Circulation 1993;88:1177-1189.
9. Lepran I, Baczko I, Varro A, et al. ATP-sensitive potassium channel modulators: Both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats. J Pharmacol Exp Ther 1996;277:1215-1220.
10. Sakata Y, Kodama K, Komamura K, et al. Salutary effect of adjunctive intracoronary nicorandil administration on restoration of myocardial blood flow and functional improvement in patients with acute myocardial infarction. Am Heart J 1997;133:616-621.
11. Horinaka S, Kobayashi N, Higashi T, et al. Nicorandil enhances cardiac endothelial NO synthase expression via activation of ATP sensitive K channel in rat. J Cardiovasc Pharmacol 2001;38:200-210.
12. Clark C, Foreman MI, Kane KA, et al. Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size. J Pharmacol Methods 1980;3:357-368.
13. Song W, Furman BL, Parratt JR. Delayed protection against ischemia-induced ventricular arrhythmias and infarct size limitation by the prior administration of Escherichia coli endotoxin. Br J Pharmacol 1996;118:2157-2163.
14. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
15. Hattori Y, Gross SS. GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: Characterization, sequence and relationship to nitric oxide synthase. Biochem Biophys Res Commun 1993;195:435-441.
16. Seki T, Naruse M, Naruse K, et al. Gene expression of endothelial type isoform of nitric oxide synthase in various tissues of stroke-prone spontaneously hypertensive rats. Hypertens Res 1997;20:43-49.
17. Nunokawa Y, Ishida N, Tanaka S. Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells. Biochem Biophys Res Commun 1993;191:89-94.
18. Akao M, Otani H, Horie M, et al. Myocardial ischemia induces differential regulation of K-ATP channel gene expression in rat hearts. J Clin Invest 1997;100:3053-3059.
19. Terada Y, Tomita K, Nonoguchi H, et al. Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments. J Clin Invest 1992;90:659-665.
20. Hattori Y, Akimoto K, Murakami Y, et al. Pyrrolidine dithiocarbamate inhibits cytokine-induced VCAM-1 gene expression in rat cardiac myocytes. Mol Cell Biochem 1997;177:177-181.
21. Kobayashi N, Kobayashi K, Hara K, et al. Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats. Am J Hypertens 1999;12:483-491.
22. Takanohashi A, Tojo A, Kobayashi N, et al. Effect of trichlormethiazide and captopril on nitric oxide synthase activity in the kidney of deoxycorticosterone acetate-salt hypertensive rats. Jpn Heart J 1996;37:251-259.
23. Mizumura T, Nithipatikom K, Gross GL. Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduced infarct size, adenosine release, and neutrophil function in dogs. Circulation 1995;92:1236-1245.
24. ATP channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits. Eur J Pharmacol 2002;5-71.
25. Takimoto Y, Aoyama T, Keyamura R, et al. Differential expression of three types of nitric oxide synthase in both infarcted and non-infarcted left ventricles after myocardial infarction in the rat. Int J Cardiol 2000;76:135-145.
26. Gourine AV, Gonon AT, Pernow J. Involvement of nitric oxide in cardioprotective effect of endothelin receptor antagonist during ischemia-reperfusion. Am J Physiol Heart Circ Physiol 2001;280:H1105-H1112.
27. Sumeray MS, Rees DD, Yellon DM. Infarct size and nitric oxide synthase in murine myocardium. J Mol Cell Cardiol 2000;32:35-42.
28. Ito H, Taniyama Y, Iwakura K, et al. Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction. J Am Coll Cardiol 1999;33:654-660.
29. The IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: The Impact of Nicorandil in Angina (IONA) randomized trial. Lancet 2002;359:1269-1275.
30. + channels by pinacidil and nicorandil. Br J Pharmacol 1998:124;985-991.
31. Palmer RMZ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-666.
32. Kubes P, Suzuki M Granger DN. Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991:88;4615-4655.