Preparation and investigation of 99m technetium-labeled low-density lipoproteins in rabbits with experimentally induced hypercholesterolemia

European Biophysics Journal

Volumn 33, Issue 2, 2004, Pages 140-145

  Bozoky Z ^a   Balogh, L ^a   Mathe D ^a   Fulop L ^a   Bertok L ^a   Janoki Gy A ^a  

^a National Research Institute for Radiobiology and Radiohygiene Budapest   (Hungary)

Author keywords

Atherosclerosis; Hypercholesterolemia; Low density lipoproteins; Technetium; Ultracentrifugation

Indexed keywords

ACETONE; APOLIPOPROTEIN; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; PROTEIN; REDUCING AGENT; SODIUM DITHIONITE; TECHNETIUM 99M;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BIOFILTER; CAROTID ARTERY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DIAGNOSTIC TEST; EARLY DIAGNOSIS; EXPERIMENTAL MODEL; GAMMA SCINTIGRAPHY; HISTOPATHOLOGY; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; ISOTOPE LABELING; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; ORGAN DISTRIBUTION; PAPER CHROMATOGRAPHY; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RABBIT; RADIOACTIVITY; SCINTILLATION CAMERA; TECHNIQUE; TRIACYLGLYCEROL BLOOD LEVEL; ULTRACENTRIFUGATION;

ANIMALS; CORONARY ARTERIOSCLEROSIS; HYPERCHOLESTEROLEMIA; ISOTOPE LABELING; LIPOPROTEINS, LDL; MALE; ORGANOTECHNETIUM COMPOUNDS; RABBITS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 3342895900     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-003-0334-7     Document Type: Article

References (21)

1. Back MR, Carew TE, Schmid-Schoenbein GW (1995) Deposition pattern of monocytes and fatty streak development in hypercholesterolemic rabbit. Atherosclerosis 116:103-115
2. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ (1995) Atherosclerosis: basic mechanisms: oxidation, inflammation, and genetics Circulation 91:2488-2496
3. Bocan TM, Mueller SB, Mazur MJ, Uhlendorf PD, Brown EQ, Kieft KA (1993) The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation. Atherosclerosis. 102:9-22
4. Brown MS, Goldstein JL (1983) Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem 52:223-261
5. Chung BH, Wilkinson T, Greer JC, Segrest JP (1980) Preparative and quantitative isolation of plasma lipoproteins: rapid, single discontinuous density gradient ultracentrifugation in vertical rotor. J Lipid Res 21:284-291
6. Cooper GR, Myers GL, Henderson LO (1991) Establishment of reference methods for lipid, lipoproteins, and apolipoproteins. Eur J Clin Chem Clin Biochem 29:269-275
7. Dixin WJ (1981) BMDP statistical software. University of California Press, Berkeley
8. Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA (1993) CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem 268:11811-11816
9. Febbraio M, Hajjar DP, Silverstein RL (2001) CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J Clin Invest 108:785-791
10. Griffith RL, Virella GT, Stevenson HC, Lopes-Virella MF (1988) Low density lipoprotein metabolism by human macrophages activated with low density lipoprotein immune complexes: a possible mechanism of foam cell formation. J Exp Med 168:1041-1059
11. Lees AM, Lees RS, Schoen FJ, Isaacsohn JL, Fischman AJ, McKusick KA, Strauss HW (1988) Imaging human atherosclerosis with 99mTc-labeled low density lipoproteins. Arteriosclerosis 8:461-470
12. Lees RS, Garabedian HD, Lees AM (1985) Technetium-99m low density lipoprotein preparation and biodistribution. J Nucl Med 26:1056-1062
13. Lindgren FT, Jensen LC, Wills RD, Freeman NK (1969) Flotation rates, molecular weight and hydrated densities of low density lipoproteins. Lipids 4:283-291
14. Medgyessy P (1977) Decomposition of superpositions of density functions and discrete distributions. Publishing House of the Hungarian Academy of Science, Budapest, p 90
15. Penn MS, Chisolm GM (1994) Oxidized lipoproteins, altered cell function and atherosclerosis. Atherosclerosis 108:S21-S29
16. Quinn MT, Parthasarathy S, Fong LG, Steinberg D (1987) Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 84:2995-2998
17. Rajavashisth TB, Andalibi A, Territo MC (1990) Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins. Nature 344:254-257
18. Restori G, Boiardi L, Barbagallo M, Novo S, Passeri M, Strano A (1990) Progression of induced aortic atherosclerosis in rabbits fed a high cholesterol diet. Int Angiol 9:263-265
19. Rong X, Shen L, Chang YH, Richters A, Hodis HN, Sevanian A (1999) Cholesterol oxidation products induce vascular foam cell lesion formation in hypercholesterolemic New Zealand White rabbits. Arterioscler Thromb Vasc Biol 19:2179-2188
20. Ross R (1986) The pathognesis of atherosclerosis: a perspective for the 1990s. Atherosclerosis 60:291-293
21. Vallabhajosula S, Goldsmith S (1990) 99mTc-Low density lipoprotein: intracellularly trapped radiotracer for noninvasive imaging of low density lipoprotein metabolism in vivo. Semin Nucl Med 1:68-79