Efficacy of celecoxib, a COX-2-specific inhibitor, and naproxen in the management of acute ankle sprain: Results of a double-blind, randomized controlled trial

Clinical Journal of Sport Medicine

Volumn 14, Issue 4, 2004, Pages 225-231

  Petrella, Robert ^a   Ekman, Evan F ^b   Schuller, Reinhard ^c   Fort, John G ^c  

^a Centre for Activity and Ageing   (Canada)

^b Providence Hospital   (United States)

^c PFIZER INC   (United States)

Author keywords

Ankle sprain; Celecoxib; COX 2 specific inhibitor; Efficacy; Naproxen; Nonspecific NSA1Ds

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; NAPROXEN;

ABDOMINAL PAIN; ACUTE DISEASE; ADULT; ANALGESIA; ANKLE PAIN; ANKLE SPRAIN; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DIARRHEA; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DYSPEPSIA; FATIGUE; FLATULENCE; FUNCTIONAL ASSESSMENT; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MELENA; MULTICENTER STUDY; NERVOUSNESS; PAIN ASSESSMENT; PARALLEL DESIGN; PATIENT SATISFACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SOMNOLENCE; STATISTICAL SIGNIFICANCE; STOMATITIS; VERTIGO; VISUAL ANALOG SCALE; VOMITING;

ACUTE DISEASE; ADULT; ANKLE INJURIES; CYCLOOXYGENASE INHIBITORS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; NAPROXEN; PAIN MEASUREMENT; PYRAZOLES; RECOVERY OF FUNCTION; SPRAINS AND STRAINS; SULFONAMIDES; TREATMENT OUTCOME;

EID: 3342891074     PISSN: 1050642X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042752-200407000-00005     Document Type: Article

References (29)

1. Perlman M, Leveille D, DeLeonibus J, et al. Inversion lateral ankle trauma: differential diagnosis, review of the literature, and prospective study. J Foot Surg. 1987;26:95-135.
2. Garrick JG. Epidemiologic perspective: symposium on ankle and foot problems in the athlete. Clin Sports Med. 1982;1:13-18.
3. Liu SH, Nguyen TM. Ankle sprain and other soft tissue injuries. Curr Opin Rheumatol. 1999;11:132-137.
4. Yeung MS, Chan KM, So CH, et al. An epidemiological survey on ankle sprain. Br J Sports Med. 1994;28:112-116.
5. McCaig LF, Nghi L. National hospital ambulatory care survey: 2000 emergency department summary. CDC. 2002;326:131.
6. Gerber JP, Williams GN, Scoville CR, et al. Persistent disability associated with ankle sprains: a prospective examination of an athletic population. Foot Ankle Int. 1998;19:653-660.
7. Wolfe MW, Uhl TL, Mattacola CG, et al. Management of ankle sprains. Am Faro Physician. 2001;63:93-104.
8. Kerkhoffs GM, Rowe BH, Assendelft WJ, et al. Immobilisation for acute ankle sprain: a systemic review. Arch Orthop Trauma Surg. 2001;121: 462-471.
9. Heere LP. Piroxicam in acute musculoskeletal disorders and sports injuries. Am J Med. 1988;84:50-55.
10. Colville MR, Amendola N, Butters MA, et al. Clinical Guideline on Ankle Injury. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1999.
11. Braun BL. Effect of ankle sprain in a general clinic population 6 to 18 months after medical evaluation. Arch Fam Med. 1999;8:143-148.
12. Verhagen RA, De Keizer G, van Dijk CN. Long-term follow-up of inversion trauma of the ankle. Arch Orthop Trauma Sur. 1995; 114:92-96.
13. Slatyer MA, Hensley MJ, Lopert R. A randomized controlled trial of piroxicam in the management of acute ankle sprain in Australian Regular Army recruits. The Kapooka Ankle Sprain Study. Am J Sports Med. 1997; 25:544-553.
14. Morn M. An observer-blind comparison of diclofenac potassium, piroxicam and placebo in the treatment of ankle sprains. Curr Med Res Opin. 1990; 12:268-274.
15. Dreiser RL, Riebenfeld D. A double-blind study of the efficacy of nimesulide in the treatment of ankle sprain in comparison with placebo. Drugs. 1993;46(suppl 1):183-186.
16. Ekman EF, Fiechtner JJ, Levy S, et al. Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain. Am J Orthop. 2002;31:445-451.
17. Ogilvie-Haris DJ, Gilbat M. Treatment modalities for soft tissue injuries of the ankle: a critical review. Clin J Sport Med. 1995;5:175-186.
18. Weiler JM. Medical modifiers of sports injury: the use of nonsteroidal anti-inflammatory drugs (NSA1Ds) in sports soft-tissue injury. Clin Sports Med. 1992;11:625-644.
19. Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis. JAMA. 2000;284:1247-1255.
20. Bombardier C, Laine L, Reicin A, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med. 2000;343:1520-1528.
21. Deeks JJ, Smith LA, Bradley MD. Efficacy, tolerability, and upper gastrointestinal safety of celecoxib treatment of osteoarthritis and rheumatoid arthritis: systemic review of randomised controlled trials. BMJ. 2002;325: 619-623.
22. Leese PT, Hubbard RC, Karim A, et al. Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial. J Clin Pharmacol. 2000;40:124-132.
23. Hockberger RS, Binder LS, Graber MA, et al. The model of the clinical practice of emergency medicine. Ann Emerg Med. 2001;37:745-770.
24. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH Harmonised Tripartite Guideline: Statistical Principles for Clinical Trials. Dept. of Health and Human Services, Food and Drug Administration, Rockville, MD. 1998.
25. Todd KH, Funk KG, Funk JP, et al. Clinical significant of reported changes in pain severity. Ann Emerg Med. 1996;27:485-489.
26. National Disease and Therapeutic Index. IMS Health. IMS Health.com. Fairfield, CT. 2002.
27. Gimbel JS, Brugger A, Zhao S, et al. Efficacy and tolerability of celecoxib versus hydrocodone/acetaminophen in the treatment of pain after ambulatory orthopedic surgery in adults. Clin Ther. 2001;23:228-241.
28. Daniels SE, Desjardins PJ, Talwalker S, et al. The analgesic efficacy of valdecoxib vs oxycodone/acetaminophen after oral surgery. J Am Dent Assoc. 2002;133:611-621.
29. Chang DT, Fricke JR, Bird SR, et al. Rofecoxib versus codeine/acetaminophen in postoperative dental pain: a double-blind, randomized, placebo and active comparator controlled trial. Clin Ther. 2001;23:1446-1455.